Effect of “DXB-2030,” a Polyherbal Formulation, on Experimental Polycystic Ovary Syndrome Associated with Hyperandrogenism by Mohammed Azeemuddin, Suryakanth D. Anturlikar, Mallappa Onkaramurthy, Mirza R. Baig, Basti K. Ashok, Raghavendra P. Rao, Mohamed Rafiq, Paramesh Rangesh

“…At the end of the study period, the animals were subjected for the estimation of serum testosterone levels, oral glucose tolerance test (OGTT), weight of the ovaries, estrous cycle, and histopathological evaluation. …”
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Phylogeny-based comparative analysis of gene expression modulation upon drought stress across three cotton diploids by Tong Huan, Xinyu Zhang, Minghua Lv, Haotian Zhou, Yanyan Zhao, Dongliang Yu, Yuqiang Sun

“…Conclusions This study reveals the diversity of drought response mechanisms among individual cotton species, identifies valuable targets for genetically enhancing drought tolerance, and provides a strategic framework for identifying candidate genes for breeding programs.…”
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Fully Covered Metallic Stents for the Treatment of Benign Airway Stenosis by Caroline Dahlqvist, Sebahat Ocak, Maximilien Gourdin, Anne Sophie Dincq, Laurie Putz, Jean-Paul d’Odémont

“…Their medical files were retrospectively reviewed in December 2014, with focus on stent’s tolerance and durability data. Results. Twenty-one stents were inserted: 13 for posttransplant left main bronchus anastomotic stricture, seven for postintubation tracheal stenosis, and one for postlobectomy anastomotic stricture. …”
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All-round enhancement induced by oxophilic single Ru and W atoms for alkaline hydrogen oxidation of tiny Pt nanoparticles by Wensheng Jiao, Zhanghao Ren, Zhibo Cui, Chao Ma, Ziang Shang, Guanzhen Chen, Ruihu Lu, Tao Gan, Ziyun Wang, Yu Xiong, Yunhu Han

“…Theoretical calculations demonstrate that the proximal single Ru atoms and the remote single W atoms synergistically optimize the electronic structure of the active Pt-site, improving the HOR activity and CO tolerance of the catalyst.…”
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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

“…The results also demonstrated that both formulations were well-tolerated, further establishing their safety profile in the context of metastatic breast cancer treatment. …”
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Therapeutic proteins immunogenicity: a peptide point of view by Feliciana Real-Fernandez, Fosca Errante, Andrea Di Santo, Anna Maria Papini, Paolo Rovero

“…Unfortunately, there are few cases where the exact mechanisms through which drugs bypass immunological tolerance and provoke immunogenicity have been studied. …”
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Role of Carrot (<i>Daucus carota</i> L.) Storage Roots in Drought Stress Adaptation: Hormonal Regulation and Metabolite Accumulation by Kyoung Rok Geem, Ye-Jin Lee, Jeongmin Lee, Dain Hong, Ga-Eun Kim, Jwakyung Sung

“…This study provides new insights into the mechanisms of tissue-specific carrot responses to drought tolerance, emphasizing that the SR plays a key role in improving drought resistance.…”
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Effects of hydrolyzed collagen supplementation for Skin Anti-Aging by Anna Gliwa, Marek Kurowski, Karolina Kuczapska, Monika Ryglewicz, Dariusz Fabian, Elbieta Leszczynska-Knaga, Natalia Jakubczyk, Weronika Rutkowska-Kawalec, Paweł Moczydłowski, Karolina Michhalczuk

“…Overall, it can be concluded that as little as 12 weeks of hydrolyzed fish collagen supplementation improves the quality and appearance of skin in the aging population.Importantly, HC-containing formulations were found to be safe and well-tolerated. However, further large-scale randomized controlled studies taking into account factors such as excipients in the supplements, age range and general lifestyle of the subjects are needed to confirm these results. …”
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N-Cadherin Upregulation Promotes the Neurogenic Differentiation of Menstrual Blood-Derived Endometrial Stem Cells by Yanli Liu, Fen Yang, Shengying Liang, Qing Liu, Sulei Fu, Zhenyu Wang, Ciqing Yang, Juntang Lin

“…Menstrual blood-derived endometrial stem cells (MenSCs) are considered an ideal therapeutic option for peripheral nerve repair due to a noninvasive collection procedure and their high proliferation rate and immunological tolerance. Here, we successfully isolated MenSCs and examined their biological characteristics including their morphology, multipotency, and immunophenotype. …”
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The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus by Yuliang Cui, Hemei Bu, Xianghua Ma, Sha Zhao, Xiaona Li, Shan Lu

“…We measured the HbA1c, serum uric acid, creatinine, lipids profiles, and so forth of 605 newly diagnosed type 2 diabetes patients, and oral glucose tolerance tests (OGTTs) were performed on each patient. …”
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Aggression from Patients or Next of Kin and Exposure to Bullying Behaviors: A Conglomerate Experience? by Iselin Reknes, Guy Notelaers, Nils Magerøy, Ståle Pallesen, Bjørn Bjorvatn, Bente Elisabeth Moen, Ståle Einarsen

“…Hence, the results of the study strengthen previous findings and suggest that managers must aim to maintain a positive psychosocial work environment with zero-tolerance for bullying.…”
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Lactic Acid Bacteria from Northern Thai (Lanna) Fermented Foods: A Promising Source of Probiotics with Applications in Synbiotic Formulation by Nittiya Suwannasom, Achiraya Siriphap, Ornampai Japa, Chonthida Thephinlap, Chutamas Thepmalee, Krissana Khoothiam

“…Five isolates demonstrating high tolerance to low pH (2.0) and 0.3% bile salts were collected and characterized. …”
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Conservative mechanism through various rapeseed (Brassica napus L.) varieties respond to heavy metal (Cadmium, Lead, Arsenic) stress by Lingyu Li, Zhanhuang Fan, Qingqin Gan, Gang Xiao, Mingbao Luan, Rilong Zhu, Zhenqian Zhang

“…Nevertheless, its ability to tolerate heavy metal stress at the molecular level remains unclear.MethodsHere, with 7-day seedlings as raw materials, we investigated physiological and biochemical indexes, analyzed the transcriptome sequencing for different treated materials (control, 50×, and 100×), combined with the results of transcriptome and proteome sequencing of the near-isogenic lines (F338 and F335) to reveal the response mechanism to heavy metal stress. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…In the pilot phase, five patients received active tDCS and were double-blindly assessed, two presenting clinical response. TDCS was well-tolerated, with no changes in cognitive scores. Conclusion. …”
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Cardiovascular Disease Risk Factor Patterns and Their Implications for Intervention Strategies in Vietnam by Quang Ngoc Nguyen, Son Thai Pham, Loi Doan Do, Viet Lan Nguyen, Stig Wall, Lars Weinehall, Ruth Bonita, Peter Byass

“…A cross-sectional survey in 2009 (2,130 adults) was done to collect data on behavioural CVDRF, anthropometry and blood pressure, lipidaemia profiles, and oral glucose tolerance tests. Four metabolic CVDRFs (hypertension, dyslipidaemia, diabetes, and obesity) and five behavioural CVDRFs (smoking, excessive alcohol intake, unhealthy diet, physical inactivity, and stress) were analysed to identify their prevalence, cluster patterns, and social predictors. …”
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Convolutional Neural Decoder for Surface Codes by Hyunwoo Jung, Inayat Ali, Jeongseok Ha

“…In addition, the locality to the qubits provides unusual tolerance to local errors. Recently, various decoding algorithms based on machine learning have been proposed to improve the decoding performance and latency of QEC codes. …”
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Element contents changes during the propagule development of two Sonneratia species by Chao Liu, Chao Liu, Chao Liu, Lin Zhang, Lin Zhang, Xiaofang Shi, Xiaofang Shi, Xiaofang Shi, Yanna Tang, Yanna Tang, Mao Wang, Mao Wang, Wenqing Wang, Wenqing Wang

“…This study investigated the propagule development of two nonviviparous mangrove species, Sonneratia alba and S. caseolaris, with marked differences in salt tolerance and distribution. Changes in the density, water content, and concentrations of the five main osmoregulatory elements (Cl, Na, K, Ca, and Mg) were determined. …”
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Enzymatic recovery of glycopeptides from different industrial grades edible bird’s nest and its by-products: nutrient, probiotic and antioxidant activities, and physicochemical cha... by Hidayati Syamimi Mohd Noor, Rafidah Mohd Ariff, Lee Sin Chang, Xin Yi Chai, Hui Yan Tan, Nur’ Aliah Daud, Abdul Salam Babji, Seng Joe Lim

“…Nitrite content (0.321–0.433 mg/L) was below the permissible tolerance level for all samples. Interestingly, the antioxidant activities (DPPH and ABTS scavenging activities and ferric reducing antioxidant powder (FRAP) activity) were significantly higher (P ≤ 0.05) in hydrolysates recovered from EBN by-products (EBNhC and EBNhD) as compared to the high grade EBN hydrolysates (EBNhA and EBNhB). …”
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Case report: Selpercatinib in the treatment of RET fusion-positive advanced lung adenocarcinoma: a challenging clinical case by Raffaella Pagliaro, Raffaella Pagliaro, Paola Maria Medusa, Paola Maria Medusa, Fabiana Vitiello, Luigi Aronne, Luigi Aronne, Susan F. M. Campbell, Susan F. M. Campbell, Fabio Perrotta, Fabio Perrotta, Andrea Bianco, Andrea Bianco

“…The patient experienced a significant reduction in tumor burden and reported improved symptom control, with no significant adverse effects during the 21-month follow-up period.ConclusionsThis case highlights the efficacy and tolerability of selpercatinib in treating advanced lung adenocarcinoma with a RET fusion. …”
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Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…Moreover, motility assays show that the compounds combination significantly impedes the motility of all cells. Drug safety and tolerability assessments were validated using the in vivo model organism Caenorhabditis elegans, where fairly high doses showed negligible impact on survival, development, or behavioral parameters. …”
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