Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice by Alexandre Fisette, Pegah Poursharifi, Katerina Oikonomopoulou, Mercedes N. Munkonda, Marc Lapointe, Katherine Cianflone

“…Mice were then subjected to both glucose and insulin tolerance tests, each manipulation being preceded by recombinant ASP or vehicle (control) bolus injection. …”
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Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatme... by Maiara Destro Inácio, Alex Rafacho, Nathália Aparecida de Paula Camaforte, Poliana Teixeira, Priscilla Maria Ponce Vareda, Natália Moretti Violato, José Roberto Bosqueiro

“…Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. …”
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Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy by Liming Wang, Yu Zhang, Hongtao Li, Jingxin Hong, Xiaobo Chen, Ming Li, Wen Bai, Jiangang Wang, Yongjun Liu, Mingyuan Wu

“…These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment.…”
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High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report by Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto

“…Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…This disorder affects approximately 6–20% of individuals, primarily emerging during early adolescence, and considerably increases the risk of conditions such as impaired glucose tolerance, type 2 diabetes, endometrial cancer, cardiovascular diseases, dyslipidemia, and postpartum complications. …”
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Evolution of drug therapy in patients with resectable gastric and esophageal‑gastric junction cancer by M. V. Sedova, M. A. Batov, V. S. Tretyak, A. A. Kolomeytseva, V. M. Khomyakov, N. N. Volchenko, A. A. Fedenko, A. D. Kaprin

“…In this regard, studies are being conducted to study the tolerability of total neoadjuvant chemotherapy, when all courses are held at the preoperative stage in order to carry out all stages of treatment in full. …”
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Protein and metabolite acclimations to temperature variability in a calcareous green macroalga Halimeda macroloba by Hao Zhang, Yuyu Wang, Lingshuai Zhang, Zhiqin Wang, Zejun Zhu, Lijuan Long, Lijuan Long

“…Enhanced nitrogen reserves, shown by increased levels of nitrogen uptake and assimilation proteins and amino acids such as pyroglutamic and N-Methyl-D-aspartic acids, likely contributed to its high-temperature tolerance. These findings highlight the resilience of H. macroloba to moderate thermal stress and suggest its important implications for reef conservation and potential applications in aquaculture as ocean temperatures rise.…”
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Micromarsupialization technique in oral ranula: report of two clinical cases in child patient by Lucas Fernando Oliveira Tomáz Ferraresso, Fábio Anevan Ubiski Fagundes, Mayra Frasson Paiva, Rodrigo Hayashi Sakuma, Cássia Cilene Dezan Garbelini, Farli Aparecida Carrilho Boer

“…Based on the reported clinical cases, it can be concluded that the use of micromarsupialization technique represents an effective surgical procedure in children due to its quick execution, conservative approach, without the use of local infiltrative anesthesia, well tolerated and with good prognosis. …”
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JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diab... by Shohei Sakata, Makoto Ito, Yasuko Mera, Tomohiko Sasase, Hiromi Yamamoto, Makoto Kakutani, Takeshi Ohta

“…JTT-130 treatment group showed improved glucose tolerance at 5 weeks after treatment and significant elevation of portal glucagon-like peptide-1 (GLP-1) levels. …”
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A single residue switch mediates the broad neutralization of Rotaviruses by Yang Huang, Feibo Song, Yuanjun Zeng, Hui Sun, Roufang Sheng, Xuechun Wang, Liqin Liu, Guoxing Luo, Yanan Jiang, Yaling Chen, Mengxuan Zhang, Shiyin Zhang, Ying Gu, Hai Yu, Shaowei Li, Tingdong Li, Qingbing Zheng, Shengxiang Ge, Jun Zhang, Ningshao Xia

“…Abstract Broadly neutralizing antibodies (bNAbs) could offer escape-tolerant and lasting protection against viral infections and therefore guide development of broad-spectrum vaccines. …”
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OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY by E. R. Nemtsova, O. A. Bezborodova, R. I. Yakubovskaya, A. D. Kaprin

“…These medications are well tolerated and do not cause any serious adverse events. …”
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Effects of axylitol-casein complex on insulin resistance and gut microbiota composition in high-fat-diet + streptozotocin-induced type 2 diabetes mellitus mice by Fanhua Kong, Juan Zhang, Shimo Kang, Xinyu Shen, Aicheng Liu, Yan Zheng, Junhua Shao, Xiqing Yue

“…XC decreased body weight and improved glucose tolerance, insulin sensitivity, pancreas impairment, blood lipid levels, and liver function in T2DM mice compared to XY- and CN-treated mice. …”
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Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats by Seungae Park, Na-Young Park, Giuseppe Valacchi, Yunsook Lim

“…HFCR lowered liver triglyceride levels, total cholesterol levels, and the plasma leptin/adiponectin ratio to normal levels and improved glucose tolerance. HFCR also improved fatty liver and normalized adipocyte size and morphology. …”
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Prediction model for spontaneous combustion temperature of coal based on PSO-XGBoost algorithm by Hui Zhuo, Tongren Li, Wei Lu, Qingsong Zhang, Lingyun Ji, Jinliang Li

“…A tenfold cross-validation method was employed to assess performance of PSO-XGBoost, PSO-RF, PSO-SVR, XGBoost, RF, and SVR models separately, the results underscored the superior predictive accuracy, robustness, fault tolerance, and universality of the PSO-XGBoost model.…”
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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity by Zahava Vadasz, Regina Peri, Nasren Eiza, Gleb Slobodin, Alexandra Balbir-Gurman, Elias Toubi

“…B regulatory cells (Bregs) belong to a subgroup of activated B cells tasked with maintaining self-tolerance and preventing autoimmunity. While sharing similar regulatory mechanisms such as IL-10 dependency, they also defer in exhibiting their suppressive effects by expressing Fas-Ligand, TGF-beta, and PDL-1. …”
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Yaws in Africa: Past, Present and Future by Ezekiel K. Vicar, Shirley V. Simpson, Gloria I. Mensah, Kennedy K. Addo, Eric S. Donkor

“…<b>Conclusions</b>: There is a great prospect for eradication if countries capitalize on the availability of simple, inexpensive, and well-tolerated oral treatment that has proven effective, validated point-of-care diagnostic tests and new molecular tests. …”
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Adaptive Interference Restriction Among Spatial Streams Based on Difference in Singular Values for PAPR Reduction in Uplink Eigenmode Massive MIMO Transmission by Yuta Abekura, Takanori Hara, Satoshi Suyama, Satoshi Nagata, Kenichi Higuchi

“…Both interference restrictions allow for more effective PAPR reduction while tolerating interference in the data streams. Computer simulations demonstrate that the transmission quality of the proposed methods is improved by up to approximately 30% compared to the case without PAPR reduction. …”
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The Comparative Efficacy and Safety of Entecavir and Lamivudine in Patients with HBV-Associated Acute-on-Chronic Liver Failure: A Systematic Review and Meta-Analysis by Jiao Yang, Hang Sun, Qi Liu

“…While entecavir and lamivudine are both relatively safe and well tolerated, entecavir was more efficacious in terms of survival rate and clinical improvement in long-term treatment. …”
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Online Structural Health Monitoring and Parameter Estimation for Vibrating Active Cantilever Beams Using Low-Priced Microcontrollers by Gergely Takács, Ján Vachálek, Boris Rohal’-Ilkiv

“…A fault signal is generated upon its departure from a predetermined nominal tolerance band. The algorithm is implemented using automatically generated and deployed machine code on an electronics prototyping platform, featuring an economically feasible 8-bit microcontroller unit (MCU). …”
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Treatment of Snoring with a Nasopharyngeal Airway Tube by Macario Camacho, Edward T. Chang, Camilo Fernandez-Salvador, Robson Capasso

“…The 28 and 30 Fr tubes abated the snoring sound the entire time worn (smartphone app: 0 snores, bedpartner VAS 0/10) but could not be tolerated more than 2.5 hours. The tube of 36 Fr size could not be inserted, despite several attempts bilaterally. …”
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