The Characterization of L-Asparaginase with Low L-Glutaminase Activity Produced by the Marine <i>Pseudomonas</i> sp. Strain GH-W2b by Woon-Jong Yu, Ha Young Lee, Yong Min Kwon, Seung Seob Bae, Grace Choi, Hyun-Ju Hwang, Dawoon Chung

“…Overall, our results suggest that GH-W2b ASNase has the potential to serve as a candidate for the development of salt-tolerant and/or alternative ASNases in pharmaceutical and food products.…”
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Safety of mineral salt containing potassium and magnesium as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Emanuela Turla, Karen Ildico Hirsch‐Ernst

“…Regarding the presence of bromide in the NF, the Panel notes that the combined daily intake of bromide from the NF and the background diet does not exceed the tolerable daily intake of bromide of 0.4 mg/kg body weight (bw) per day. …”
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Design and application of a novel device for recovering and storing gastric juices (一种新型胃液回收及存储装置的设计与应用) by WANG Weiwei (王伟伟), ZHANG Meng (张萌), SUN Xiumei (孙秀梅)

“…Gastric residual volume monitoring can well assess gastrointestinal motility and enteral nutrition tolerance, and is also the most commonly used indicator to identify high aspiration risk. …”
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A Three‐Terminal Memristive Artificial Neuron with Tunable Firing Probability by Mila Lewerenz, Elias Passerini, Luca Weber, Markus Fischer, Nadia Jimenez Olalla, Raphael Gisler, Alexandros Emboras, Mathieu Luisier, Miklos Csontos, Ueli Koch, Juerg Leuthold

“…This approach simultaneously grants low‐power operation as well as a high degree of noise immunity and fault tolerance at a small footprint and simplistic structure of the neurons. …”
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Regulatory mechanisms tuning ethylen signaling in plants by E. V. Zemlyanskaya, N. A. Omelyanchuk, A. A. Ermakov, V. V. Mironova

“…Among others ethylene controls such practically significant characteristics of agricultural crops as fruit ripening rates and plant tolerance to stress conditions. That is why understanding molecular mechanisms underlying ethylene action is one of the basic questions in plant biology that is addressed in the context of both fundamental research and application in agriculture. …”
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Exploring pyrazolines as potential inhibitors of NSP3-macrodomain of SARS-CoV-2: synthesis and in silico analysis by Rekha Joshi, Harsh Gaikwad, Bhavana Soge, Abdulrahman Alshammari, Norah A. Albekairi, Atul Kabra, Usha Yashwante, Baban Kolte, Pradip Lokhande, Rohan J Meshram

“…The protocol is applicable to a variety of β-amino ketones and tolerates several functional groups. This method is efficient and proceeds regioselectivity since the β-Anilino group acts as a protecting group for alkenes of chalcones. …”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Impressively, morusinol treatment exhibited potent tumor growth inhibition in vivo, proving both well-tolerated and safe in mouse models. Moreover, our investigation identified FUT8, a fucosyltransferase, as a potential target for morusinol. …”
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Safety and Efficacy of 188-Rhenium-Labeled Antibody to Melanin in Patients with Metastatic Melanoma by M. Klein, M. Lotem, T. Peretz, S. T. Zwas, S. Mizrachi, Y. Liberman, R. Chisin, J. Schachter, I. G. Ron, G. Iosilevsky, J. A. Kennedy, E. Revskaya, A. W. de Kater, E. Banaga, V. Klutzaritz, N. Friedmann, E. Galun, G. L. DeNardo, S. J. DeNardo, A. Casadevall, E. Dadachova, G. B. Thornton

“…The data demonstrate that 188Re-6D2 was well tolerated, localized in melanoma metastases, and had antitumor activity, thus warranting its further investigation in patients with metastatic melanoma.…”
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Fungi with potential probiotic properties isolated from Fuzhuan brick tea by Xin Wang, Yuanyuan Cui, Chaowei Sang, Bin Wang, Yirong Yuan, Lin Liu, Yahong Yuan, Tianli Yue

“…Of the 18 strains, 10 tolerated simulated human digestive conditions for sufficient periods in vitro: pH 2-3, 0.3%-0.5% (m/V) bile salts, and artificial gastrointestinal juices. …”
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Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells by Inge L. Huibregtse, Sebatian A. Zaat, Martien L. Kapsenberg, Maria A. Sartori da Silva, Maikel P. Peppelenbosch, Sander J. H. van Deventer, Henri Braat

“…Interleukin-10 (IL-10) plays an indispensable role in mucosal tolerance by programming dendritic cells (DCs) to induce suppressor Th-cells. …”
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Phenotypic analysis of sorghum [Sorghum bicolor (L) Moench] genotypes for drought responsive traits by Atnafu Kebede, Geleta Dugassa Barka, Mulugeta Kebede, Temesgen Matiwos Menamo, Taye Tadesse

“…This study aimed to evaluate the genetic variation and heritability of shoot and root traits that contribute to drought tolerance in sorghum genotypes. A total of 158 genotypes were analyzed using a high-throughput phenotyping platform. …”
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Wheat cultivars grain yield and quality traits variability under conditions of southern Pannonian plain by Timić Jovana, Dražić Tanja, Mirosavljević Milan, Jocković Bojan, Aćin Vladimir, Mikić Sanja, Brbaklić Ljiljana

“…All analyzed traits are significant for breeding programs, emphasizing the importance of developing high-quality varieties with high yield potential and tolerance to adverse environmental conditions.…”
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Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR‐Cas12a by Xin Guan, Rui Yang, Jiongyu Zhang, Jeong Moon, Chengyu Hou, Chong Guo, Lori Avery, Danielle Scarola, Daniel S. Roberts, Rocco LaSala, Changchun Liu

“…Here, the mismatch profiles, including the quantity, location, and type of mismatches in the CRISPR‐Cas12a reaction, are investigated and its various tolerances to mismatches are discovered. By harnessing the specificity defect of the CRISPR‐Cas12a enzyme, a dual‐mode detection strategy is designed, which includes approximate matching and precise querying of target sequences and develop a programmable multiplexed nucleic acid assay. …”
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Effects of various manufacturing parameters and test temperature and crosshead displacement rate on the peel resistance of UHMWPE composites by Omar Banabila, Noora Alahmed, Rubayea Alameri, Rafael Santiago, Kamran A. Khan, Wesley J. Cantwell

“…The results showed that fracture energy remained relatively stable across this processing window, confirming a broad manufacturing tolerance. The effect of displacement rate and test temperature on delamination resistance was also investigated by conducting peel tests at different displacement rates from 0.2 to 200 mm/min and temperatures ranging from 25 to 100°C. …”
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The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure by Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang

“…The behavior responses of D. magna in DM (13.36 μg/L and 33.40 μg/L) and MT (19.66 μg/L and 49.15 μg/L) suggested that recovery behavior in the adjustment phase was crucial, and behavior homeostasis provided them with an optimal way to achieve a wider tolerance against environmental stress. During the experiment, positive effects on AChE activity occurred in the beginning of the exposure. …”
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Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia by Toni Spence, Philip J. Allsopp, Alison J. Yeates, Maria S. Mulhern, J. J. Strain, Emeir M. McSorley

“…The maternal immune response is essential for successful pregnancy, promoting immune tolerance to the fetus while maintaining innate and adaptive immunity. …”
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Tecovirimat in the management of poxviruses: a narrative review of available evidence by Olalekan John Okesanya, Jerico Bautista Ogaya, Ikponmwosa Jude Ogieuhi, Mohamed Mustaf Ahmed, Bonaventure Michael Ukoaka, Ojoisimi Franca Jamgbadi, Deborah Oluwaseun Shomuyiwa, Don Lucero-Prisno Eliseo, Blessing Olawunmi Amisu, Olakulehin Adebusuyi, William K. Chung, Emery Manirambona, Nimat Bola Idris, Janet Alexis A. De los Santos

“…Recovery times, virus eradication, and symptom relief varied among studies, but wider access and usage showed better clinical symptoms and tolerable side effects. Tecovirimat’s efficacy against circulating strains has been experimentally demonstrated. …”
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The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults by Ha Thi Ngo, Ragna Bogen Hetland, Inger-Lise Steffensen

“…Body weight at 11 weeks was increased after a 45% fat diet during nursing, during both in utero and nursing, and throughout life, but had normalized at 23 weeks. In the glucose tolerance test, the early exposure to a 45% fat diet in utero, during nursing, or during both in utero and nursing, did not affect blood glucose, whereas a 45% fat diet given to adults or throughout life did. …”
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Combination Trimodality Therapy Using Vismodegib for Basal Cell Carcinoma of the Face by Alec M. Block, Fiori Alite, Aidnag Z. Diaz, Richard W. Borrowdale, Joseph I. Clark, Mehee Choi

“…After multidisciplinary discussion, we recommended and he opted for combined modality of vismodegib, radiotherapy, and local excision. The patient tolerated vismodegib well and his right cheek lesion decreased significantly in size. …”
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Total Lip Reconstruction with Tendinofasciocutaneous Radial Forearm Flap by Eldad Silberstein, Yuval Krieger, Yaron Shoham, Ofer Arnon, Amiram Sagi, Alexander Bogdanov-Berezovsky

“…In one case where palmaris longus was missing hemi-flexor carpi radialis tendon was used instead. All patients tolerated the procedure well. Results. All flaps totally survived. …”
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