Current Perspectives on Treatment of Gram-Positive Infections in India: What Is the Way Forward? by Atul P. Kulkarni, Vasant C. Nagvekar, Balaji Veeraraghavan, Anup R. Warrier, Deepak TS, Jaishid Ahdal, Rishi Jain

“…Another challenge is the spectrum of adverse effects related to the safety and tolerability profile of the currently available drugs used against GPIs which further makes the management and treatment of these multidrug resistant organisms a complex task. …”
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Identification of candidate genes for leaf size by QTL mapping and transcriptome sequencing in Brassica napus L by Fengjie Cheng, Yuwen Wang, Aoyi Peng, Shuyu Li, Jun Chen, Xiaoxiao Zheng, Jie Xiong, Ge Ding, Bingchao Zhang, Wen Zhai, Laiqiang Song, Wenliang Wei, Lunlin Chen

“…These findings provided further insights into the genetic mechanism of leaf size and built fundamental theory basis for high-density tolerance breeding in rapeseed.…”
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Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models by Chrystal Paulos, Gregory B Lesinski, Zachary S Buchwald, Nabil F Saba, Vikash Kansal, Andre J Burnham, Brendan L C Kinney, Nicole C Schmitt

“…Results from flow cytometry of tumors and tumor-draining lymph nodes suggested T cell activation and shifts from M2 to M1 macrophage predominance as potential mechanisms of combination therapy.Conclusions These results suggest that statins deserve further study as well-tolerated, inexpensive drugs that may enhance responses to PD-1 checkpoint blockade and other immunotherapies for HNSCC.…”
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Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN by Yiolanda-Panayiota Christou, George A. Tanteles, Elena Kkolou, Annita Ormiston, Kostas Konstantopoulos, Maria Beconi, Randall D. Marshall, Horacio Plotkin, Kleopas A. Kleopa

“…Fosmetpantotenate was well-tolerated with only transient liver enzyme elevation which normalized after dose reduction and did not recur after subsequent dose increases. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…PGEVs exhibited remarkable stability, tolerating acidic digestion and undergoing minimal changes in simulated gastrointestinal fluid. …”
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Metabolomic and morphological trait diversity display contrasting patterns in temperate forest tree communities by Jonathan J. Henn, Brian E. Sedio, Christopher P. Catano, Emily Dewald‐Wang, Dilys Vela Díaz, James A. Lutz, Sean M. McMahon, Geoffrey Parker, Jonathan A. Myers, Marko J. Spasojevic

“…While these patterns have primarily been explored with morphological functional traits related to environmental tolerances and resource acquisition, plant metabolomics may provide an additional functional dimension of community assembly to expand our understanding of how niche selection changes along environmental gradients. …”
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Comprehensive GC-MS Characterization and Histochemical Assessment of Various Parts of Three <i>Colchicum</i> Species from Bulgarian Flora by Ivayla Dincheva, Ilian Badjakov, Vasil Georgiev, Ivanka Semerdjieva, Radka Vrancheva, Ivan Ivanov, Atanas Pavlov

“…Conversely, flowers, leaves, and capsules were enriched with energy-related and phenolic compounds, playing critical roles in reproduction and stress tolerance. Histochemical investigations localized alkaloids predominantly in the endosperm of seeds, parenchyma of corms, and vascular bundles of flowers. …”
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Changes in the content of proteins and lipids and in the state of the antioxidant system in mutant forms of <i>Amaranthus cruentus</i> L. by R. M. Taipova, V. N. Nesterov, O. A. Rozentsvet, B. R. Kuluev

“…An increase in salt tolerance compared to the control was observed in mutants No. 2 and No. 3. …”
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Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases by Mohamed Elbadawy, Nagisa Saito, Yuki Kato, Kimika Hayashi, Amira Abugomaa, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Masahiro Kaneda, Hideyuki Yamawaki, Kazuaki Sasaki, Tatsuya Usui, Tsutomu Omatsu

“…To study these viruses’ pathogenicity and proliferation efficacy and viral tolerance mechanisms in bats, bat-derived cell lines, and primary cultured cells are used. …”
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Effect of a multimodal analgesia strategy on remifentanil daily consumption in mechanically ventilated adult ICU patients: study protocol for a randomised, placebo-controlled, doub... by Thibault Mura, Jean-Yves Lefrant, Remy Widehem, Camille Nicolet, Violaine Delannoy, Laurie Barthelemi, Ian Soulairol, Claire Roger

“…Secondary outcomes will include drug tolerance, mechanical ventilation duration, ICU and hospital length of stay, 28-day and 90-day mortalities and 90-day opioid consumption.Ethics and dissemination The study protocol was accepted by the Nîmes University Hospital’s research committee, the French ethics committee (Institutional Review Board OUEST IV) and the French National Agency for the Safety of Medicines and Health Products (ANSM).Trial registration number ClinicalTrials.gov: NCT05825560…”
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Identification and Characterization of the Diverse Stress-Responsive R2R3-RMYB Transcription Factor from Hibiscus sabdariffa L. by Bahaeldeen Babikar Mohamed, Beenish Aftab, Muhammad Bilal Sarwar, Bushra Rashid, Zarnab Ahmad, Sameera Hassan, Tayyab Husnain

“…The RMYB transcription factor-overexpressing in transgenic cotton plants may be used as potential agent for the development of stress tolerant crop cultivars.…”
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Vascularized Composite Allograft Rejection Is Delayed by Intrajejunal Treatment with Donor Splenocytes without Concomitant Immunosuppressants by Christopher Glenn Wallace, Chia-Hung Yen, Hsiang-Chen Yang, Chun-Yen Lin, Ren-Chin Wu, Wei-Chao Huang, Jeng-Yee Lin, Fu-Chan Wei

“…Background. Mucosal or oral tolerance, an established method for inducing low-risk antigen-specific hyporesponsiveness, has not been investigated in vascularized composite allograft (VCA) research. …”
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Genome-Wide Expression Profiles of Hemp (Cannabis sativa L.) in Response to Drought Stress by Chunsheng Gao, Chaohua Cheng, Lining Zhao, Yongting Yu, Qing Tang, Pengfei Xin, Touming Liu, Zhun Yan, Yuan Guo, Gonggu Zang

“…Gene Ontology (GO) and KEGG analysis illuminated particular important biological processes and pathways, which enriched many candidate genes such as NAC, B3, peroxidase, expansin, and inositol oxygenase that may play important roles in hemp tolerance to drought. Eleven KEGG pathways were significantly influenced, the most influenced being the plant hormone signal transduction pathway with 15 differentially expressed genes. …”
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Interaction between arbuscular mycorrhizal fungi and dark septate endophytes in the root systems of Populus euphratica and Haloxylon ammodendron under different drought conditions... by Huimei Wang, Huimei Wang, Hengfang Wang, Hengfang Wang, Shengtao Wei, Shengtao Wei, Li Sun, Li Sun, Li Sun, Linlin Cheng, Linlin Cheng

“…Background and AimsArbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) are known to enhance the tolerance of host plants to biotic and abiotic stresses, but the mechanism of their interaction under natural conditions has not been extensively studied.MethodsWe analyzed the endophytic fungal diversity and colonization characteristics in the typical desert plants Populus euphratica and Haloxylon ammodendron and the relationship between them and environmental factors.ResultsExcept for DSE in the roots of H. ammodendron, the colonization rates of AMF and DSE were significantly positively correlated with drought severity. …”
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A Hybrid Retrieval Method for an &#x03A9;-Class Bianisotropic Metamaterial Using Scattering Parameter Method by Gokhan Ozturk, Ugur Cem Hasar, Yunus Kaya, Huseyin Korkmaz, Ivaylo Stoyanov

“…Contrary to two sample configurations required in the application of previous retrieval methods in the literature, one sample configuration (with and without its rotation in the transverse plane) significantly decreases the effect of fabrication tolerances on the accuracy of extraction. The proposed extraction method is first validated by a bulk MM slab synthesized by the Lorentz and Drude models. …”
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Survival and Effect of Exopolysaccharide-Producing Lactobacillus plantarum YW11 on the Physicochemical Properties of Ice Cream by Zhang Jian, Zhao Wen, Guo Xialei, Guo Ting, Zheng Yi, Wang Yuetong, Hao Yijiang, Yang Zhennai

“…The ice cream processing and storage conditions also affected the YW11 strain’s tolerance to acid and bile, with a decrease in survival rate of 38.8–63.2% and 10.8–51.8%, respectively. …”
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Comprehensive genome-wide analysis of ARF transcription factors in orchardgrass (Dactylis glomerata): the positive regulatory role of DgARF7 in drought resistance by Miaoli Wang, Wen Liu, Guangyan Feng, Gang Nie, Zhongfu Yang, Feixiang Hao, Linkai Huang, Xinquan Zhang

“…Notably, DgARF7 enhanced drought tolerance through heterologous expression in yeast and overexpression in Arabidopsis. …”
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ELEVATED BLOOD LEAD LEVELS IN WOMEN OF REPRODUCTIVE AGE DUE TO LEADS EXPOSURE FROM CONTAMINATED WATER by Perdina Nursidika, Dedeh Kurnia, Ganthina Sugihartina

“…Meanwhile, lead levels in the blood ranged from 1.5 ug/dL to 78.2 ug/dL, with 6.7% falling within the normal category, 40% in the tolerable category, 30% in the excess category, and 23.3% in the high category. …”
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Complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770 from coal mine of Hongcheon on Republic of Korea by Min-Kyu Park, Yeong-Jun Park, Myung-Suk Kang, Min-Ha Kim, Soo-Young Kim, Jae-Ho Shin

“…The aim focused on identifying microbes that enhance plant growth in metal-tolerant environments and evaluating the strain's bioremediation and agricultural uses. …”
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Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes by Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang

“…The TIM3/galectin-9 pathway plays an important role in immune tolerance. Herein, we aimed to investigate the expression of TIM3 and galectin-9 in peripheral blood and to evaluate their clinical significance in patients with obesity and obesity-related T2DM. …”
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