Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties by Md. Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S. M. Abdur Rahman

“…The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test. Results. Metal complexes significantly (P<0.001) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner. …”
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A collaborative parent-teacher model for religious moderation education in early childhood in Indonesia by M. Suyuti Yusuf, Hadi Pajarianto, Baso Sulaiman

“…The values instilled in children include religious moderation, national commitment, non-violence, a love of local culture and tolerance. Conclusion: The collaboration between parents and teachers is reflected in the participatory activities initiated by parents in various school programmes, reinforcing the cultural responsibility of parents and the structural responsibilities of teachers. …”
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The genetic diversity of reed canarygrass (Phalaris arundinaceae L.) assessed by isozyme markers by R. S. Yudina, E. K. Khlestkina

“…Among the major advantages of the reed canarygrass are high biomass yield, ecological stability, tolerance, and high seed production. Similar to most of wild-growing plants, the reed canarygrass is poorly studied. …”
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Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein. by Qian Qiu, Zihan He, Jing Liu, Huijun Xu, Jinyu Wang, Nannan Liu, Ning Kang, Shaokun Pan, Weien Yu, Zixiang Gao, Shimei Zhang, Yang Yang, Qiang Deng, Youhua Xie, Jiming Zhang, Zhongliang Shen

“…In chronic hepatitis B (CHB) patients, immune active phase (IA) is associated with higher intrahepatic expression of MSX1, DNAJA4 and CRYAB, and lower serum HBV markers compared to immune tolerant (IT) phase. Finally, HBV infection is significantly suppressed by MSX1 overexpression in both NTCP-overexpressing cell and humanized liver mouse models. …”
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Symbiont Community Changes Confer Fitness Benefits for Larvae in a Vertically Transmitting Coral by Daniel Olivares‐Cordero, Courtney Timmons, Carly D. Kenkel, Kate M. Quigley

“…Larvae that survived heat exposure exhibited changes in symbiont communities that favored symbionts that are canonically more stress tolerant. Compared to larvae, juveniles showed more rapid mortality under heat stress and their symbiont communities were largely fixed regardless of temperature treatment, suggesting an inability to alter their symbiont community as an acclimatory response to heat stress. …”
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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway by Nana Wang, Tiegang Li, Ping Han

“…Eight weeks later, fasting blood glucose (FBG) and oral glucose tolerance tests (OGTT) were performed. Area under the curve (AUC) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated, and PI3-K/AKT signal pathway-related genes and proteins were tested by reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis in muscle, adipose, and liver tissues, respectively. …”
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Classifying the Involvement of Men and Women in Climate Smart Agricultural Practices in Kayonza Sub-county by Turyasingura, Benson, Ayiga, Natal

“…Improved cooking stoves, fisheries and aquaculture, pasture management and planting of plant tolerant verities were among the CSA practices. The study recommends that the government should develop a strategy plan for gender quality based on goals that reflect an awareness of the economic and social implications of compromised climate smart agriculture. …”
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Monte Carlo Algorithm For Matrices in Solving Systems of Linear Equations, Determinants, Inverse, Eigen Values, and Eigenvectors. by Bamwine, Delik

“…Monte Carlo methods, which are based on statistical sampling, exhibit many attractive properties in dealing with large volumes of datasets, including fast approximated results, memory efficiency, reduced data accesses, natural parallelism, and inherent fault tolerance. This research assessed Monte Carlo methods to accommodate a set of fundamental and ubiquitous large-scale linear algebra operations, including solving large-scale linear systems, constructing low-rank matrix approximation, and approximating the extreme eigenvalues/ eigenvectors, across modern distributed and parallel computing architectures. …”
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Classifying the Involvement of Men and Women in Climate Smart Agricultural Practices in Kayonza Sub-county, Kanungu District, Uganda by Benson, Turyasingura, Ayiga, Natal

“…Improved cooking stoves, fisheries and aquaculture, pasture management and planting of plant tolerant verities were among the CSA practices. The study recommends that the government should develop a strategy plan for gender quality based on goals that reflect an awareness of the economic and social implications of compromised climate smart agriculture. …”
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From Isolation to Application: Utilising Phage‐Antibiotic Synergy in Murine Bacteremia Model to Combat Multidrug‐Resistant Enterococcus faecalis by Fatma Al‐zahraa A. Yehia, Galal Yahya, Eslam M. Elsayed, Javier Serrania, Anke Becker, Salwa E. Gomaa

“…This phage specifically lysed 42% of HLGR isolates. vB_EfaS_SZ1 demonstrated beneficial traits, including thermal stability, acid–base tolerance, a short latent period, and a large burst size. …”
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Acute metabolic decompensation after liver transplant in a patient with maple syrup urine disease by Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S. Kulkarni, Elizabeth Toolan, Dorothy K. Grange

“…Liver transplant is an effective therapy for MSUD, and patients can usually tolerate a regular diet after transplant without symptomatic metabolic decompensation. …”
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CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…In primates, we observed a long serum half-life, deep and sustained depletion of normal B cells, and remarkable tolerability, in particular, reduced cytokine release when CLN-978 was administered subcutaneously.Conclusions CLN-978 warrants further exploration. …”
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Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility by Chenyue Qian, Heming Guo, Xiaohong Chen, Aiming Shi, Sicheng Li, Xin Wang, Jie Pan, Chen Fang

“…The programmed death- (PD-) 1/PD-1 ligand (PD-L) pathway plays an important role in regulating T cell activation and maintaining peripheral tolerance. Accumulated studies showed that PD-1/PD-L1 pathway was involved in the development of type 1 diabetes (T1DM). …”
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Ecogenomic insights into the resilience of keystone Blastococcus Species in extreme environments: a comprehensive analysis by Imed Sbissi, Farah Chouikhi, Faten Ghodhbane-Gtari, Maher Gtari

“…Ecogenomic assessments highlighted the genus's capabilities in substrate degradation, nutrient transport, and stress tolerance, particularly on stone surfaces and archaeological sites. …”
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Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C by Zehui Yan, Ke Fan, Xiaohong Wang, Qing Mao, Guohong Deng, Yuming Wang

“…The peg-IFN α-2a 90 μg/week plus ribavirin is as effective as, and better tolerated than, peg-IFN α-2a standard dose with ribavirin in the treatment of chronic hepatitis C. …”
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Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors by Yuan Shi, Changhao Deng, Xiangyin Lu, Yan Wang, Yaowen Pan, Deding Su, Wang Lu, Yuxiang Lin, Rui Li, Junnan Han, Yanwei Hao, Yi Chen, Ghassen Abid, Julien Pirrello, Mondher Bouzayen, Yudong Liu, Zhengguo Li, Baowen Huang

“…Plants deficient in SlGRAS9, SlZHD17, or SlMBP3 exhibit thickened cuticles and a higher accumulation of cutin monomers, conferring extended fruit shelf life and higher tolerance to postharvest fungal infection. SlGRAS9 regulation of cutin is mediated by SlZHD17, a negative regulator of SlCYP86A69. …”
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The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes by Jun Li, Siyuan Li, Ying Hu, Guolei Cao, Siyao Wang, Partab Rai, Xiaoli Wang, Kan Sun

“…One hundred Uyghur subjects where divided into two groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of individual units were generated by the EpiTyper v1.0.5 software. …”
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Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein by Wenhui Lu, Baoli Sun, Jianyue Mo, Xiduo Zeng, Guanqun Zhang, Lianxiang Wang, Qingfeng Zhou, Ling Zhu, Zhili Li, Qingmei Xie, Yinzuo Bi, Jingyun Ma

“…Following PRRSV experimental challenge, pigs inoculated with a single dose of QY1 P100 developed no significant clinic symptoms and well tolerated lethal challenge, while QY1 P80 group still developed mild fever in the clinic trial after challenge. …”
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The Influence of Ouabain on Human Dendritic Cells Maturation by C. R. Nascimento, R. C. Valente, J. Echevarria-Lima, C. F. L. Fontes, L. de Araujo-Martins, E. G. Araujo, V. M. Rumjanek

“…Collectively, our results suggest that DCs respond to Ouabain maturating into a distinct category, possibly contributing to the balance between immunity and tolerance.…”
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Introducing the Index of Response to Stimulation (IRES): A Novel Metric for Assessing Vagus Nerve Stimulation Outcomes in Drug-Resistant Epilepsy by Flavius-Iuliu Urian, Corneliu Toader, Razvan-Adrian Covache Busuioc, Antonio-Daniel Corlatescu, Horia Petre Costin, Gabriel Iacob, Alexadru Vlad Ciurea

“…Therapy settings were adjusted biweekly to optimize efficacy and patient tolerance. <i>Results</i>: There were improvements in the control of the seizures, measured in terms of increased IRES scores. …”
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