A Component-Based Parametric Reduced-Order Modeling Method Combined with Substructural Matrix Interpolation and Automatic Sampling by Ying Liu, Hongguang Li, Yun Li, Huanyu Du

“…The exact error of the assembled model at the optimal parameter point is subsequently calculated to determine whether the automatic sampling procedure reaches a desired error tolerance. The proposed framework is then applied to the moving coil of electrical-dynamic shaker to illustrate the advantage and validity. …”
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Fault Diagnosis of Piezoelectric Sensor Patches for Vibration Control Based on Multifeature Fusion and Improved SVM by Tian-bing Ma, Zhou Qing, Du Fei, Liu Jian

“…The fault diagnosis of piezoelectric sensor patches is very important for the stability of the vibration control system and fault-tolerant control technology. In order to improve the accuracy of fault self-diagnosis of piezoelectric sensor patches, singular value decomposition (SVD) and Hilbert marginal spectrum method are proposed to extract multiple features of each IMF component and conduct feature fusion, and a support vector machine (SVM) based on particle swarm optimization (PSO) is designed for fault identification of different eigenvalues. …”
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Copolymer SJ-1 as a Fluid Loss Additive for Drilling Fluid with High Content of Salt and Calcium by Hongping Quan, Huan Li, Zhiyu Huang, Tailiang Zhang, Shanshan Dai

“…Good temperature resistance and salt tolerance of “–SO3-” of AMPS, strong absorption ability of “amino-group” of AM, and good hydrability of side chain polyoxyethylene ether (C2H4O)n of APEG provide SJ-1 excellent properties as a fluid loss additive. …”
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Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: where do we stand and what may be the future? by Beatrice Maranini, Roberta Foti, Moustapha Taha, Veronica Venturelli, Andrea Lo Monaco, Marcello Govoni

“…In some cohorts, JAKis determined even an encouraging improvement in lung disease, and few reports presented good tolerability of JAKis in combination with antifibrotics. …”
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Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice by Domenico Rizzo, Enrico Ravera, Marco Fragai, Giacomo Parigi, Claudio Luchinat

“…Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. …”
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A meta-analytic evaluation of the efficacy and safety of levetiracetam for treating myoclonic seizures by Sara Najafi, Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia

“…Furthermore, it is well-tolerated and responsible for a few side-effects. However, it is necessary to monitor carefully LEV's individual response.…”
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Transcriptomic Analysis Reveals Molecular Mechanisms Underpinning Mycovirus-Mediated Hypervirulence in <i>Beauveria bassiana</i> Infecting <i>Tenebrio molitor</i> by Charalampos Filippou, Robert H. A. Coutts, Ioly Kotta-Loizou, Sam El-Kamand, Alexie Papanicolaou

“…Genes that participate in carbohydrate assimilation and transportation, and those essential for fungal survival and oxidative stress tolerance, calcium uptake, and iron uptake, were found to be overexpressed in the virus-infected isolate during the mid-infection stage. …”
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Investigation of Digital Light Processing-Based 3D Printing for Optimized Tooling in Automotive and Electronics Sheet Metal Forming by Szabolcs Szalai, Brigitta Fruzsina Szívós, Vivien Nemes, György Szabó, Dmytro Kurhan, Mykola Sysyn, Szabolcs Fischer

“…Measurements using digital image correlation (DIC) revealed minimal wear and deformation, with tolerances consistently within IT 0.1 mm. The results demonstrated that SLA-printed tools perform comparably to conventional metal tools in cutting and bending operations, achieving similar surface quality and edge precision while significantly reducing the production time and cost. …”
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Retention and Clinical Performance of Zirconia Crowns: A Comprehensive Review by Fatemeh Soleimani, Hamid Jalali, Azam Sadat Mostafavi, Somayeh Zeighami, Maryam Memarian

“…Overall, although clinical long-term and follow-up studies are a vital requirement to conclude that zirconia has great reliability, it seems that zirconia crown restorations are both well tolerated and sufficiently resistant.…”
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Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade by Yu Chen, Yu Guo, Wen Cheng, Jiahao Fan, Jiacheng Li, Jiajia Song, Xiaohai Yang, Kemin Wang, Jin Huang

“…Besides tumor killing and immune promotion, activated NS downregulate PD‐L1 expression, alleviating immune tolerance and evasion, thus enhancing the immune response. …”
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Cytokine Reduction in the Setting of an ARDS-Associated Inflammatory Response with Multiple Organ Failure by Karl Träger, Christian Schütz, Günther Fischer, Janpeter Schröder, Christian Skrabal, Andreas Liebold, Helmut Reinelt

“…CytoSorb treatment was safe and well tolerated, with no device-related adverse effects observed.…”
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Biological Characteristics and Whole Genome Analysis of vB_VpP_3, a Bacteriophage against Multi-drug Resistant Vibrio parahaemolyticus by LIU Qingqing, ZHANG Ming, YANG Wenjing, LIU Ke, LI Fan, LI Xuepeng, LI Jianrong, ZHANG Defu

“…The one-step growth curve showed that the latent period of the phage was 15 min, the average burst size was 110 PFU, and it was highly tolerant to the environment. Phage vB_VpP_3 belonged to the order Caudovirales of the family Podoviridae with a regular icosahedral head about 60 nm in diameter and a non-contractile tail about 20 nm in length. …”
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Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase by Gülşah P. Özgün, Emel B. Ordu, H. Esra Tütüncü, Emrah Yelboğa, Richard B. Sessions, Nevin Gül Karagüler

“…The thermodynamic and kinetic results suggest that 8 mutations on the first residue can be tolerated. Among all mutants, M1L has the best residual activity after incubation at 60°C with 17%. …”
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Transcutaneous Vagus Nerve Stimulation Combined with Robotic Rehabilitation Improves Upper Limb Function after Stroke by Fioravante Capone, Sandra Miccinilli, Giovanni Pellegrino, Loredana Zollo, Davide Simonetti, Federica Bressi, Lucia Florio, Federico Ranieri, Emma Falato, Alessandro Di Santo, Alessio Pepe, Eugenio Guglielmelli, Silvia Sterzi, Vincenzo Di Lazzaro

“…Compared to traditional stimulation, noninvasive VNS seems to be safer and more tolerable. Further studies are needed to confirm the efficacy of this innovative approach.…”
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Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

“…In 2015, the release of well-tolerated, short course treatments (~12 weeks) able to cure the majority of treated HCV patients revolutionized HCV therapy. …”
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Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development by Montserrat Carrasco-Triguero, Helen Davis, Yuda Zhu, Daniel Coleman, Denise Nazzal, Paul Vu, Surinder Kaur

“…This assay showed good sensitivity, drug tolerance, and reproducibility across a variety of antibody-derived biotherapeutics without the need for optimization across molecules.…”
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Numerical and Experimental Investigations on Dynamic Response of Hydraulic Cylinder with 3D Spatial Joints considering Radial and Axial Clearances by Ke Chen, Guojun Zhang, Haishuo Wang, Rui Wu, Hongmei Zheng, Shunhua Chen

“…Radial clearance, particularly the axial clearance in the 3D joint of a mechanism owing to the assemblage, manufacturing tolerances, wear, and other conditions, has become a research focus in the field of multibody dynamics in recent years. …”
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Zinc Affects Differently Growth, Photosynthesis, Antioxidant Enzyme Activities and Phytochelatin Synthase Expression of Four Marine Diatoms by Thi Le Nhung Nguyen-Deroche, Aurore Caruso, Thi Trung Le, Trang Viet Bui, Benoît Schoefs, Gérard Tremblin, Annick Morant-Manceau

“…Among the four species, A. paludosa was the most sensitive and A. coffeaeformis, the most tolerant. A. acutiuscula seemed to be under metal starvation, whereas, to survive, only N. palea developed several stress responses.…”
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Double Barreled Wet Colostomy: Initial Experience and Literature Review by Luis Salgado-Cruz, Eloy Espin-Basany, Francesc Vallribera-Valls, Jose Sanchez-Garcia, Luis Miguel Jimenez-Gomez, Marc Marti-Gallostra, Ana Garza-Maldonado

“…In the group of our patients with pelvic exenteration and urinary tract reconstruction with a DBWC, it is a safe procedure and well tolerated by the patients, and most of the complications can be resolved with conservative treatment.…”
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Development and Validation of an Age-Specific Lower Extremity Finite Element Model for Simulating Pedestrian Accidents by Jing Huang, Yongcheng Long, Yu Yan, Lin Hu

“…However, current computational models only represent certain ages in the population, the age spectrum of the pedestrian victims is very large, and the geometry of anatomical structures and material property of the lower extremities changes with age for adults, which could affect the injury tolerance, especially in at-risk populations such as the elderly. …”
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