The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation by Xiaowei Chen, Yu Wang, Fang Xu, Xiaofei Wei, Junfang Zhang, Chuang Wang, Hua Wei, Shujun Xu, Peiyun Yan, Wenhua Zhou, Istvan Mody, Xiaohong Xu, Qinwen Wang

“…In the present study, for the first time we investigated the effect of different doses of BPA on hippocampal LTP in rat brain slices. …”
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Peroral Endoscopic myotomy (POEM) in pediatric achalasia: a retrospective cohort on institutional experience and quality of life by Thijs Kuipers, Carlijn Mussies, Aaltje Lei, Gwen M.C. Masclee, Marc A. Benninga, Paul Fockens, Barbara A.J. Bastiaansen, Albert J. Bredenoord, Michiel P. van Wijk

“…Abstract Background Achalasia is a rare esophageal motility disorder with an estimated annual incidence of 1–5/100.000 and a mean age at diagnosis > 50 years of age. …”
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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan by Tsukasa Okamoto, Mariko Hanafusa, Taketomo Abe, Takashi Shimamura, Masaru Ito, Yoko Wakai, Torahiko Jinta, Katsuyuki Higa, Yasuhiro Kondoh, Yasumi Okouchi, Ryo Okuda, Masashi Bando, Takafumi Suda, Hiromi Tomioka, Takeo Fujiwara, Masato Takase, Shigemi Yoshihara, Hiroshi Odajima, Yasunari Miyazaki

“…The estimated prevalence and incidence of fibrotic HP were 6.3 and 2.5 per 100,000 population, respectively, versus 3.6 and 2.0 per 100,000 population, respectively, for non-fibrotic HP. …”
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Efficacious removal of mercury metal in food industry sewerage utilizing reduced graphene oxide adsorbent composited with magnetic nanoparticles by Adel Beig Babaei, Arash Dara, Hanieh Sadat Taheri

“…The study's focus lay on investigating mercury removal efficiency across varying pH levels (1–6), temperatures (25 °C), mercury concentrations (10 g/L), adsorbent amounts (0.01–0.05 g/L), and contact times (120–360 s). The findings indicated that optimal mercury adsorption occurred at pH 6, with a 100 s contact time, 25 °C, and 0.05 g of adsorbent. …”
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Discovery and Validation of Potential Serum Biomarkers for Heart Failure by Untargeted Metabolomics by Guisheng Zhou, Junzhi Zhang, Hongli Guo, Xiaochao Hu, Yingzhuo Wang, Kunqun Shi, Tongtong Liu, Shengyan Yin, Huanhuan Liu, Chunling Liu, Shijia Liu

“…In this study, serum samples from 83 patients with HF and 35 HCs were used as the research subjects for untargeted metabolomic analysis using ultraperformance liquid chromatography combined with quadrupole-time of flight mass spectrometry (UPLC-QTOF/MS) technology. …”
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Composition of Web Services Using Markov Decision Processes and Dynamic Programming by Víctor Uc-Cetina, Francisco Moo-Mena, Rafael Hernandez-Ucan

“…Our experimental work shows how the solution of a WSC problem involving a set of 100,000 individual Web services and where a valid composition requiring the selection of 1,000 services from the available set can be computed in the worst case in less than 200 seconds, using an Intel Core i5 computer with 6 GB RAM. …”
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Spectroscopic Investigations and DFT Calculations on 3-(Diacetylamino)-2-ethyl-3H-quinazolin-4-one by Yusuf Sert, Fatih Ucun, Gamal A. El-Hiti, Keith Smith, Amany S. Hegazy

“…The experimental Laser-Raman spectrum (4000–100 cm−1) and FT-IR spectrum (4000–400 cm−1) of the newly synthesized compound were recorded in the solid phase. …”
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Induction of somatic embryogenesis and cryopreservation of Abies pinsapo Boiss. by Laura Cabero-Moreno, Ignacio Landeras-López, María Victoria Bravo-Navas, Carolina Sánchez-Romero

“…The best results were achieved after sucrose preculture and cryoprotecion with PGD I (mixture of polyethylene glycol, glucose and DMSO I), with 100% of explants resuming somatic embryogenesis after thawing. …”
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Estimating the Geological Strength Index (GSI) in Regional Seismic-Landslide Zonation Using the Empirical Regression Model by M. E. Mirabedini, E. Haghshenas, N. Ganjian

“…The assessment of the strength parameters of geological formations in regional scale which encounters thousands of slopes is a complicated approach and time consuming and needs huge field work. This issue is an important research topic concerning the regional seismic-landslide susceptibility analysis or hazard zonation. …”
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Bilayer electrified-membrane with pair-atom tin catalysts for near-complete conversion of low concentration nitrate to dinitrogen by Xuanhao Wu, Xiaoxiong Wang, Yunshuo Wu, Huimin Xu, Zhe Li, Rongrong Hong, Kali Rigby, Zhongbiao Wu, Jae-Hong Kim

“…The sequential cathode-to-anode electrofiltration realizes near-complete removal of 10 mg-N L−1 NO3 − and ~100% N2 selectivity with a water resident time on the order of seconds. …”
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Estimation of Volatile Organic Compounds (VOCs) and Human Health Risk Assessment of Simulated Indoor Environment Consisting of Upholstered Furniture Made of Commercially Available... by Alena Capíková, Daniela Tesařová, Josef Hlavaty, Adam Ekielski, Pawan Kumar Mishra

“…Highly elastic foam K5040, standard PU foam N5063, bonded polyurethane foam R100, viscoelastic foam V5020, self-extinguishing foam KF5560, and foam rubber were used. …”
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Pb (II) Recovery by Modified Tuffite: Adsorption, Desorption, and Kinetic Study by Beyhan Kocadagistan, Kubra Oksuz

“…The effects of contact time (0–90 min), adsorbent dosage (1–10 g/L), initial concentration (10–200 mg/L), and pH (2–12) on the removal of Pb (II) were investigated. …”
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Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled tria... by Dr Sana Fatima, Dr Sonali Taneja, Dr Vivek Aggarwal, Dr Akriti Dheer, Dr Punya Taneja

“…Group 3 showed lesser pain at all-time intervals. Conclusion: All the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of intake of analgesics.…”
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Investigating the Effects of Performing the Early Mobilization Protocol on Postoperative Hemorrhaging in Cardiac Surgery Patients by Hanie Dahmardeh

“…Methods: This research is a clinical trial study conducted in 2023-2024 at Ali Ibn AbiTalib Hospital in Zahedan, Iran, on 100 patients undergoing cardiac surgery. Purposive sampling was used based on the inclusion criteria. …”
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Cost-effectiveness analysis of tislelizumab plus chemotherapy as the first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma in China. by Chaoneng He, Xiufang Mi, Gaoqi Xu, Xinglu Xu, Wenxiu Xin, Like Zhong, Junfeng Zhu, Qi Shu, Luo Fang, Haiying Ding

“…In the probabilistic sensitivity analysis, when the willingness-to-pay threshold was set as 1 or 3 times GDP per capita, the probability of tislelizumab plus chemotherapy being cost-effective was 1% and 100%, respectively.…”
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Backtesting Quantum Computing Algorithms for Portfolio Optimization by Gines Carrascal, Paula Hernamperez, Guillermo Botella, Alberto del Barrio

“…The benefits and drawbacks of backtesting are discussed, as well as some of the challenges involved in using real quantum computers of more than 100 qubits. Results show quantum algorithms can be competitive with classical ones, with the advantage of being able to handle a large number of assets in a reasonable time on a future larger quantum computer.…”
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Do They Know It’s Christmas? by Cees Hesp

“…The machine costs $200,000 to purchase and install. It produces 100,000 liters of clean water per day, using nothing but free and plentiful seawater and sunshine. …”
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MODELING AND SIMULATION OF A DUAL CHANNEL ACTIVE NOISE CONTROL SYSTEM FOR POWER TRANSFORMER USING FXLMS ALGORITHM by ADETONA SUNDAY, SALAWU RAIFU, ALABI MORUF

“… Power transformers are known to generate noise, however, active noise emanating from power transformers many at time is unbearable and has been a subject of concern overtime in power engineering. …”
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Visual and Refractive Outcomes following Bilateral Implantation of Extended Range of Vision Intraocular Lens with Micromonovision by Sri Ganesh, Sheetal Brar, Archana Pawar, Kirti J. Relekar

“…Reading acuity and reading speeds showed improvement over time. Between defocus range of −2.50 and +1.00 D, the visual acuity remained ≥0.2 logMAR. …”
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