1-(5-ACETYL-3-METHYL-6-PHENYL-5H-[1,2,4]TRIAZOLO [3,4-b][1,3,4]THIADIAZIN-7-YL)-ETHANONE: DOSE-DEPENDENCE OF ANALGESIC EFFECT, LACK OF OPIOIDERGIC MECHANISM OF ACTION, EFFECT ON BE... by Andriy Koval, Sergiy Shtrygol

“…The average increase in the LP nociceptive response during its use per se was 306.3%, and during the previous blockade of opioid receptors with naloxone - 204.4%, that is, it decreased on average by a third, and the median of the final latent time decreased by 2 times with almost the same initial value. …”
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Changing consumption of resources for respiratory support and short-term outcomes in four consecutive geographical cohorts of infants born extremely preterm over 25 years since the... by Alicia J Spittle, Lex W Doyle, Peter J Anderson, Li Huang, Jeanie L Y Cheong, Alice C Burnett, Anjali Haikerwal, Merilyn Bear, Margaret Charlton, Janet Courtot, Noni Davis, Julianne Duff, Rachel Ellis, Marie Hayes, Elisha Josev, Elaine Kelly, Marion Mcdonald, Emma Mcinnes, Bronwyn Novella, Gillian Opie, Gehan Roberts, Katherine Scott, Penelope Stevens, Anne-marie Turner, Kim M Dalziel, Katherine Lee, Marissa Clark, Joy E Olsen, Rosemarie A Boland, Alice E Stewart, Leah M Hickey

“…Cystic periventricular leukomalacia decreased (6.3% (1991–1992) to 1.2% (2016–2017)), whereas retinopathy of prematurity requiring treatment increased (4.0% (1991–1992) to 10.0% (2016–2017)). The average additional costs associated with one additional infant surviving in 2016–2017 were 200 (95% CI 150 to 297) days, 326 (183 to 1127) days and 130 (70 to 267) days compared with 1991–1992, 1997 and 2005, respectively.Conclusions Consumption of resources for respiratory support has escalated with improved survival over time. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…In the 4-OI treatment experiment, mice were randomly divided into the sham group, DMM group, DMM + 4-OI (50 mg/kg) group, and DMM + 4-OI (100 mg/kg) group. Von Frey tests and open field tests were conducted at intervals during the 12 weeks following the DMM surgery. …”
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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial by Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob P. Laubach, Giada Bianchi, Elizabeth O’Donnell, Ting Wu, Junko Tsuji, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

“…MRD-negativity (10-5 sensitivity) predicted a 5-year biochemical PFS of 100% versus 40% in MRD-positive patients (p = 0.051), demonstrating that deep responses significantly improve time to progression. …”
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LoCS-Net: Localizing convolutional spiking neural network for fast visual place recognition by Ugur Akcal, Ugur Akcal, Ugur Akcal, Ivan Georgiev Raikov, Ekaterina Dmitrievna Gribkova, Ekaterina Dmitrievna Gribkova, Anwesa Choudhuri, Anwesa Choudhuri, Seung Hyun Kim, Mattia Gazzola, Rhanor Gillette, Rhanor Gillette, Ivan Soltesz, Girish Chowdhary, Girish Chowdhary, Girish Chowdhary

“…Still, training SOTA SNNs for VPR is often intractable on large and diverse datasets, and they typically demonstrate poor real-time operation performance. To address these shortcomings, we developed an end-to-end convolutional SNN model for VPR that leverages backpropagation for tractable training. …”
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One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID‐19 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, C... by Ondrej Šušol, Barbora Šušolová, Ondřej Klempíř, Milan Navrátil, Jaromír Gumulec, Zdeněk Kořístek, Juraj Ďuraš, Michal Kaščák, Jana Mihályová, Lukáš Stejskal, Tomáš Jelínek, Petra Richterová, Lenka Szeligová, Hana Plonková, Jana Zuchnická, Barbora Dluhošová, Ivo Demel, David Buffa, Katarína Hradská, Tereza Popková, Ludmila Muroňová, Martin Lachnit, Klára Lančová, Roman Hájek

“…On the contrary, patients with chronic myeloproliferative neoplasms and acute leukemia performed comparably with healthy population (33/33; 100% and 12/13; 92.3%, respectively). We have seen better results if the time interval between anti‐CD20 therapy and additional vaccine dose was longer than 6 months (5/8 patients achieved seroconversion on 4th booster dose after previous failure). …”
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Implementation and validation of a new qPCR assay to detect imported human Plasmodium species by Camille Cordier, Samia Hamane, Théo Ghelfenstein-Ferreira, Sarah Dellière, Élodie Da Silva, Blandine Denis, Sandrine Houzé, Valentin Joste, Alexandre Alanio

“…We have developed duplex (Plasmodium spp. and Plasmodium falciparum) real-time PCR (qPCR) and species-specific qPCR assays for the identification and quantification of human Plasmodium species. …”
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Structure of Patients with Hepatocellular Cancer (Data Analysis from Two Specialised Centres) by M. V. Mayevskaya, M. S. Novruzbekov, I. M. Borovkov, D. G. Trofimova, M. S. Zharkova, V. D. Lunkov, K. N. Lutsyk, O. D. Olisov

“…The highest five-year survival rate (100 %) was found in the group of patients who received antiviral therapy (AVT) before and after liver transplantation.Conclusions. …”
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福莫特罗对哮喘小鼠气道杯状细胞增生及 粘蛋白MUC5ac mRNA表达的影响

“…【目的】 探讨长效β2受体激动剂福莫特罗对哮喘(支气管哮喘)小鼠气道杯状细胞增生及粘蛋白MUC5ac mRNA表达的影响65377;【方法】 40只雌性SPF级BABL/c小鼠,随机分为4组,每组10只65377;A组为生理盐水对照组;B组为卵蛋白(ovalbumin,OVA)哮喘组;C组为哮喘福莫特罗干预组;D组为哮喘地塞米松干预组65377;在末次激发24 h后所有小鼠取左肺组织行过碘酸雪夫(PAS)染色,采用医学图像分析软件测定支气管上皮杯状细胞面积占上皮细胞总面积的百分比并计算杯状细胞数量65377;取右肺组织行real-time qRT-PCR,检测粘蛋白MUC5ac mRNA的表达65377;【结果】 B组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平显著高于A组[(163.63 ± 16.68)个vs (0.46 ± 0.16)个,(77.36 ± 5.05)% vs (0.03 ± 0.01)%,(10.31 ± 0.73) vs ( 1.00 ± 0.13),P均 < 0.05];C组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平均低于B组[(52.04 ± 4.60)个 vs (163.63 ± 16.68)个,(30.05 ± 3.72)% vs (77.36 ± 5.05)%,(1.64 ± 0.14) vs (10.31 ± 0.73),P均 < 0.05] ;D组小鼠支气管上皮杯状细胞的数量65380;杯状细胞占上皮细胞总面积的百分比和MUC5ac mRNA水平均低于B组[(63.41 ± 6.39)个 vs (163.63 ± 16.68)个,(38.52 ± 3.83)% vs(77.36 ± 5.05)%,(1.72 ± 0.10) vs (10.31 ± 0.73),P均 < 0.05];C组和D组的杯状细胞数量65380;面积百分比和MUC5ac mRNA水平间差异均无统计学意义[(52.04 ± 4.60)个 vs (63.41 ± 6.39)个,(30.05 ± 3.72)% vs (38.52 ± 3.83)%,(1.64 ± 0.14 ) vs (1.72 ± 0.10),P均 > 0.05]65377;【结论】 长效β2受体激动剂福莫特罗可抑制哮喘小鼠气道杯状细胞增生及粘蛋白MUC5ac mRNA的表达65377;…”
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Rehospitalization burden and morbidity risk in patients with heart failure with mid‐range ejection fraction by Enrique Santas, Rafael de laEspriella, Patricia Palau, Gema Miñana, Martina Amiguet, Juan Sanchis, Josep Lupón, Antoni Bayes‐Genís, Francisco Javier Chorro, Julio Núñez Villota

“…Rates of all‐cause readmission per 100 patients‐years of follow‐up were 150.1, 176.9, and 163.6 in HFrEF, HFmrEF, and HFpEF, respectively (P = 0.097). …”
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Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula by Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa

“…However, the optimal timing for conducting the procedure in those diagnosed with postoperative pancreatic fistula (POPF) has not been established. …”
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Realizing low voltage-driven bright and stable quantum dot light-emitting diodes through energy landscape flattening by Yiting Liu, Yingying Sun, Xiaohan Yan, Bo Li, Lei Wang, Jianshun Li, Jiahui Sun, Yaqi Guo, Weipeng Liu, Binbin Hu, Qingli Lin, Fengjia Fan, Huaibin Shen

“…The record-high luminance levels of 1,400 and 8,600 cd m-2 are achieved at bandgap voltages of 100% and 120%, respectively. Meanwhile, These LEDs show an unprecedented operation lifetime T95 (time for the luminance to decrease to 95%) of 72,968 h at 1,000 cd m-2. …”
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Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2... by Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen

“…HIV seroconversion was significantly lower among PrEP users at private clinics compared to public clinics (0.03 vs. 0.13 per 100 person-years, respectively; p &lt; 0.01).ConclusionOffering choice in PrEP service delivery options is essential to increase access and uptake. …”
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Construction and Pathogenicity Analysis of a GFPuv-labeled Peanut Ralstonia solanacearum Strain by Jinling HUANG, Yushuang WU, Huiquan TANG, Minyi HUANG, Ruixue YANG, Qiang WANG, Yong YANG, Xiaodan TAN

“…【Objective】The study aimed to construct a GFPuv-labeled peanut Ralstonia solanacearum, which was used to observe the infection pathway in host plants in real-time. Meanwhile, genomic integration sites suitable for exogenous gene were identified.…”
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The incidence of incomplete abortion and the prevalence of abortion-related morbidity in South African public hospitals, 2018 by D N Conco, J Levin, B Komane, K Blanchard, T Bessenaar, N G Nkosi, S Fonn

“…The proportion of women presenting in the first trimester increased over time: 60.5% in 1994, 67.1% in 2000 and 73.9% in 2018. …”
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Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

“…Seventy- eight animals from three farms were divided into 3 groups by age: 80-100 day old calves (N=26); 16-18 months  old heifers (N=26) and 3-6 year old cows in dry status (N=26). …”
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Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…Introduction Idiopathic nephrotic syndrome is the most common glomerular disease in childhood with an incidence of 1.8 cases per 100 000 children in Germany. The treatment of the first episode implies two aspects: induction of remission and sustainment of remission. …”
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DFT and molecular docking analyses of the effects of solvent polarity and temperature on the structural, electronic, and thermodynamic properties of p-coumaric acid: Insights for a... by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tadesse Lemma Wakjira, Dereje Gelanu, Tesfaye Feyise, Jebel Haji Mahamud, Abdulkerim Abdela, Kebede Shankute Gizew

“…Time-dependent DFT (TDDFT) analysis revealed that solvent polarity influenced UV–Vis absorption and excited-state dipole moments, leading to significant changes in electronic transitions. …”
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Hooks, Lines, and Sinkers: How Active Galactic Nucleus Feedback and Cosmic-Ray Transport Shape the Far-infrared–Radio Correlation of Galaxies by Sam B. Ponnada, Rachel K. Cochrane, Philip F. Hopkins, Iryna S. Butsky, Sarah Wellons, N. Nicole Sanchez, Cameron Hummels, Yue Samuel Lu, Dušan Kereš, Christopher C. Hayward

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Incidence of self-reported tuberculosis treatment with community-wide universal testing and treatment for HIV and tuberculosis screening in Zambia and South Africa: A planned analy... by L Telisinghe, S Floyd, D MacLeod, A Schaap, R Dunbar, J Bwalya, N Bell-Mandla, E Piwowar-Manning, D Donnell, K Shaunaube, P Bock, S Fidler, R J Hayes, H M Ayles, HPTN 071 (PopART) study team

“…Overall incidence rates were similar across all arms in 2014 and 2015 (0.33 to 0.46/100 person-years). In 2016 incidence rates were lower in arm A compared to C overall (adjusted rate ratio [aRR] 0.48 [95% confidence interval (95% CI) 0.28 to 0.81; p = 0.01]), with statistical significance reached. …”
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