A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…QALYs were obtained from the CodeBreak 100 trial and the literature. The costs of drugs, drug administration, diagnostics, disease management, and adverse events were considered. …”
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Elucidating epigenetic landscape of gastric premalignant lesions through genome‐wide mapping of 5‐hydroxymethylcytosines: A 12‐year median follow‐up study by Zhongguang Luo, Wenshuai Li, Wanwei Zheng, Yixiang Shi, Maolin Ye, Xiangyu Guo, Kaiyi Fu, Changsheng Yan, Bowen Wang, Bin Lv, Shaocong Mo, Hongyang Zhang, Jun Zhang, Chuan He, Feifei Luo, Wei Zhang, Jie Liu

“…The nine‐gene model showed an area under the curve of 87.5% (95% confidence interval: 72%–100%) in the validation samples (one of three), which were set aside before model training. …”
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Simultaneous estimation of multiple soil properties from vis-NIR spectra using a multi-gate mixture-of-experts with data augmentation by Xiaoqing Wang, Mei-Wei Zhang, Ya-Nan Zhou, Lingli Wang, Ling-Tao Zeng, Yu-Pei Cui, Xiao-Lin Sun

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Kefir Prevents Adipose Tissue Growth Through the Induction of Apoptotic Elements in High-Fructose Corn Syrup-Fed Rats by Esra Aslan, Gokhan Sadi, Hilal Guzel, Cigdem Karaca, Omer Adil Korkmaz, Mine Kanat Pektas, Mehmet Celegen, Tugce Aladag, Seyma Oncu, Mehmet Bilgehan Pektas

“…HFCS (20%, w/v ) was given in drinking water and kefir (1 mL/100 g body weight) by gastric gavage daily for 8 weeks. …”
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Parents' perception of the promotion of physical activity as part of the Purzelbaum project in Swiss daycare centers by Bianca Celine Schmidli, Claudio R. Nigg

“…Results Parents (n=353; mean age=37.93, SD=5.24; 86% completed Bachelor; 73% female; mean # of days children spent in daycare=2.39, SD=1.00; 84 Purzelbaum and 278 non-Purzelbaum daycare centers) completed the questionnaire. …”
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Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center by Cinzia Brunelli, Sara Alfieri, Emanuela Zito, Marco Spelta, Laura Arba, Linda Lombi, Luana Caselli, Augusto Caraceni, Claudia Borreani, Anna Roli, Rosalba Miceli, Gabriele Tine', Ernesto Zecca, Marco Platania, Giuseppe Procopio, Nicola Nicolai, Luigi Battaglia, Laura Lozza, Morena Shkodra, Giacomo Massa, Daniele Loiacono, Giovanni Apolone

“…However, there are barriers to implementation related to the time and cognitive effort required to complete the questionnaires. …”
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Green synthesis of nano-copper oxide using Sargassum sp. functionalized in cellulose acetate membrane for dye adsorption by U. Yanuhar, H. Suryanto, M. Amin, J.S. Binoj, I. Casuarina

“…The objective of the current study is to assess the properties of the green synthesis product of nano-copper oxide by employing Sargassum sp. macroalgae and its functionalized cellulose acetate membrane for the purpose of dye adsorption.METHODS: The preparation of Sargassum sp. extract involved utilizing quantities of 2.5, 5.0, and 10.0 grams, which were subsequently combined with a copper sulphate solution to yield nano-copper oxide. …”
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Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

“…This framework enables comparisons of these effects over time and across different regions.…”
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Rapid and specific on-site H5Nx avian influenza diagnosis via RPA and PAM-independent CRISPR-Cas12a assay combined with anti-NP antibody-based viral RNA purification by Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Seung-Ji Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Kang-Seuk Choi, Kang-Seuk Choi

“…Currently, RT-qPCR with spin column RNA extraction is the gold standard for HPAIV surveillance, but its long reaction time and need for specialized equipment limit its effectiveness for rapid response. …”
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Performance evaluation of the high-throughput quantitative Alinity m Epstein-Barr virus assay by D. Yitzchak Goldstein, Mark M. Sasaki, Momka Narlieva, Nhi Nhan, Tianxi Liu, April Kegl, Tanjina Akter, Tanisha Dickerson, Eriel Thornton, Patricia Jim, Stephen Young, Danijela Lucic, Julie W. Hirschhorn

“…Alinity m EBV detected 100% of panels at 1.3 Log IU/mL, and precision ranged from 1.9% to 5.2% coefficients of variance (SD ≤ 0.14 Log IU/mL). …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…The options of antiviral therapy (AVT) in the stages of severe liver fibrosis and cirrhosis (LC) as well as in the patients with comorbidities for the long time were limited to the standard therapy by pegilated interferon (peg-IFN) in combination to ribavirin (RBV). …”
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Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…DNA was extracted using a commercial kit and tested via nested PCR for the ftsZ gene, as well as conventional PCR and qualitative real-time PCR using Sybr® Green for the citrate synthase gene (gltA), all specific reactions for B. henselae. …”
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Preliminary study on unlocking growth and yield potential of USDA foxtail millet (Setaria italica L.) lines with NPK fertilization by Hira Shahzadi, Shahbaz Khan, Abdulrahman Al-Hashimi, Shahzad M. A. Basra, Kashf Mehmood, Muhammad Ashfaq Wahid, Muhammad Nawaz, Sohail Irshad, Abdul Haseeb, Afroz Rais, Safia Gul, Danish Ibrar, Yheni Dwiningsih

“…Furthermore, all genotypes achieved a complete final emergence percentage of 100, except U2 (92.89%) and V19 (89.33%). The highest growth rate and assimilation rate were observed in V111 and V107 under the impact of treatment 5. …”
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The Use of L-Menthol in Endoscopic Transpapillary Interventions. Prospective Randomized Dual-Center Study by M. A. Anishchenko, M. A. Nazmeev, S. G. Shapovalyants, S. A. Budzinsky, A. V. Rogov, R. R. Zaynutdinov, A. S. Melnikova, E. D. Fedorov, E. N. Platonova

“…In general, successful cannulation was achieved in 100 % of patients in group “L”, and in 94.5 % — in the control group (p < 0.05). …”
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Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle an... by Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Yasushi Iijima, Yoshiaki Torii, Jun Ueno, Atsuhiro Yoshida, Ken Tomochika, Sumihisa Orita, Yawara Eguchi, Kazuhide Inage, Yasuhiro Shiga, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Hisateru Niki, Seiji Ohtori, Shohei Minami

“…Comparison between patients with the lower instrumented vertebra (LIV) at L4 or lower and L3 or higher revealed significantly higher disc scores and 100% prevalence of DD in the L4 or lower group. …”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…Group 2 also showed significantly longer durations for motor blockade (918.75±65.80 minutes vs. 632.60±23.09 minutes, p=3.10×10-44), postoperative analgesia (1051.00±90.18 minutes vs. 811.12±17.23 minutes, p=1.00×10-28), and time for rescue analgesia (1116.75±93.96 minutes vs. 826.50±13.92 minutes, p=2.40×10-32). …”
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Performance of antiretroviral drugs supply chain management and related challenges in Amhara National Regional State, Ethiopia. In the case of public health facilities found in the... by Meseret Tilahun Zeleke, Berhanemeskel Weldegerima Atsbeha, Belachew Yebeyin Melaku, Yesuneh Tefera Mekasha, Abibo Wondie Mekonen, Shimelis Dagnachew Nigatu

“…About 42.8 % of hospitals and 26 % of health centers placed at least two emergency orders within the previous six months at the time of data collection. The storage condition of ARV drugs was not good (68.99 %) in health centers. …”
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Association Between Adolescent Violence Exposure and the Risk of Suicide: A 15-Year Study in Taiwan by Chieh Sung, Chi-Hsiang Chung, Chien-An Sun, Chang-Huei Tsao, Daphne Yih Ng, Tsu-Hsuan Weng, Li-Yun Fann, Fu-Huang Lin, Wu-Chien Chien

“…Controlled grouping was conducted by 1:10 matching based on gender, age, and the time of medical treatment, and a control group who had not experienced violence was selected for comparison. …”
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Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis by Sebastian Nowak, Dominik Creuzberg, Maike Theis, Carmen Pizarro, Alexander Isaak, Claus C. Pieper, Julian A. Luetkens, Dirk Skowasch, Alois M. Sprinkart, Daniel Kütting

“…For MTFL no significant correlation to spirometry parameters was found. The total time for one analysis was lower for the automated MTFL (MTFL: 313 ± 25s vs. …”
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Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro... by Nancy Pan, Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Beth Gottlieb, Julia G. Harris, Julia G. Harris, Tzielan Lee, Tzielan Lee, Y. Ingrid Goh, Y. Ingrid Goh

“…Barriers to PRO collection cited were limited time, lack of infrastructure, and lack of staff. …”
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