CRISPR/Cas13a combined with reverse transcription and RPA for NoV GII.4 monitoring in water environments by Yiqiang Sun, Weiwei Zhang, Houyun Zhang, Feng Zhao, Laijin Su

“…The results of the two methods showed 100 % concordance with no significant difference in viral load. …”
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Association Between Patient-Reported Pain and Remission or Low Disease Activity in Patients with Rheumatoid Arthritis: Data from RA-BE-REAL Prospective Observational Study by Peter C. Taylor, Walid Fakhouri, Samuel Ogwu, Ewa Haladyj, Inmaculada de la Torre, Bruno Fautrel, Rieke Alten, Peter Nash, Eugen Feist

“…Pain was measured using the visual analogue scale (VAS) (0–100 mm) and clinically meaningful pain improvement thresholds of ≥ 30%, ≥ 50% and ≥ 70% from baseline to 3, 6, 12 and 24 M. …”
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Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy by Khurram Shahzad, Martin Cadeiras, Sarfaraz Memon, Barry Zeeberg, Tod Klingler, Anshu Sinha, Esteban G. Tabak, Sreevalsa Unniachan, Mario C. Deng

“…Out of 8 transcripts available for RT-PCR analysis, we confirmed 6 transcripts (75.0%) including FPRL1, S100A9, CXCL10, PRO1073, and MMP9 (P<.05). Conclusion. …”
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Valorization of pinecone as a pyrolysis feedstock: identification of bio-oil and synthesis of activated biochar for Cr(VI) elimination from wastewater by Alfares, Amenah Adnan, Younis, Afyaa Muayed, Rasheed, Lana Abdalhameed, Fadhil, Abdelrahman Basil

“…The ABC exhibited an adsorptive elimination of 98.71% for 100 mL of solution containing 150 ppm of Cr(VI) from its aqueous phase using 0.20 g of ABC at 35 °C for 140 min and a pH = 2.0. …”
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Clinical validation of a biopsy‐based six‐gene signature prognostic for aggressive prostate cancer by Agnieszka Krzyzanowska, Debra F. Higgins, Stephen Barron, Tony Loughman, Amanda O'Neill, Katherine M. Sheehan, Chan‐Ju Angel Wang, Bozena Fender, Leah McGuire, Joanna Fay, Anthony O'Grady, Des O'Leary, R. William Watson, Anders Bjartell, William M. Gallagher

“…Methods MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason (≥G4) and high pathological T‐stage (≥T3) were assessed by likelihood ratio statistics and area under the receiver operating characteristic curves from logistic regression models; time to biochemical recurrence was assessed by likelihood ratio statistics and C‐indexes from Cox proportional hazard regression models. …”
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Oxyuris spp. Infection in Green Iguana (Iguana iguana) Under Different Cage Types by shelly kusumarini, Rafi Dzakir Ghalib, Garvasilus Privantio Tegar Virgiawan Huler, Reza Yesica, Nanis Nurhidayah, Haris Muhamad, Nuha Fairusya

“…At the same time, there is a significant relationship (P<0,05) between the type of cage and the infection rate of Oxyuris spp. …”
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Comparative study of phenotypic and genotypic expression of virulence factors in colonizing and pathogenic carbapenem resistant Acinetobacter baumannii (CRAB) by Swati Sharma, Kamal Singh, Ashish Chaurasiya, Tuhina Banerjee, Royana Singh, Ghanshyam Yadav, Ashok Kumar

“…The virulent genes pgaA, csuE, bap, ompA, abaI, pilA and bauA were detected by simplex-PCR and Quantitative Real-Time PCR was done for expressional studies. In-vivo survival percentage was studied by Galleria mellonella (wax moth) killing assay. …”
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Students Perceptions, Satisfactions and Challenges on Problem-Based Learning (PBL): A Survey Study Among Final Year Pharmacy Students by Engku Nuraishah Huda E. Zainudin, Fakhira Damia Khaidir, May Khin Soe, Nurul Asyiqin Yusof, Khairool Azizul Mohammad

“…Although, most findings highlight positive aspects of PBL, this study also identified three major challenges in PBL implementation, namely 1) insufficient time for PBL preparation, 2) lack of teamwork, and 3) difficulty in finding adequate reading materials. …”
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ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study by Demis Zelelew, Milkyas Endale, Yadessa Melaku, Taye B. Demissie, Japheth O. Ombito, Rajalakshmanan Eswaramoorthy

“…In the present study, a new series of nine Thiazolo[3,2-α] pyrimidine analogs were synthesized in good to excellent yields (87.9–96.9%) and improved reaction time using a ZnO nanoparticle-assisted protocol. …”
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Heterogeneous long-term changes in larch forest and shrubland cover in the Kolyma lowland are not captured by coarser-scale greening trends by Heather Kropp, Michael M Loranty, Howard Epstein, Gerald V Frost, Adam Koplik, Logan T Berner

“…Increases in shrubland cover were highest in proximity to surface water (<100 m) and in close proximity to areas with stable shrubland cover. …”
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The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…Abstract Background Wound healing is a restoration process of tissue integrity and function targeting reducing the healing time and complications with priority of available, acceptable and affordable medication. …”
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Investigating the Effect of Coffee Husk Ash as Partial Replacement of Cement in Concrete C30. by Niwainamani, Laban

“…The initial and final setting time of OPC - CHA at 5% replacement was observed to be 79 minutes and 431 minutes respectively. …”
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Impact of Gender-Based Violence on Social Wellbeing in Rukiga District: A case Study of Muhanga Town Council Rukiga District. by Amanya, Grace

“…Based on the results from the study, 100% of the respondents agreed that there are various forms of domestic violence in Muhanga town council, Rukiga district. …”
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Field Deployment of a Mobile Biosafety Laboratory Reveals the Co-Circulation of Dengue Viruses Serotype 1 and Serotype 2 in Louga City, Senegal, 2017 by Idrissa Dieng, Maryam Diarra, Moussa Moïse Diagne, Martin Faye, Marie Henriette Dior Ndione, Yamar Ba, Mamadou Diop, El Hadji Ndiaye, Paolo Marinho de Andrade Zanotto, Boly Diop, Mamadou Ndiaye, Abdoulaye Bousso, Ndongo Dia, Mawlouth Diallo, Aliou Barry, Gamou Fall, Cheikh Loucoubar, Amadou Alpha Sall, Ousmane Faye, Oumar Faye

“…Serotyping revealed two serotypes, Dengue 1 (100/104; 96, 15%) and Dengue 2 (04/104; 3, 84%). …”
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Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…Incidence rates (IRs; patients with events/100 patient-years [PY]; 95% CIs) of first-time occurrences were obtained for adverse events (AEs) of interest.Results 7061 patients received tofacitinib (total exposure: 22 875 PY; median [range] exposure: 3.1 [0 to 9.6] years). …”
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Effect of intradermal acupuncture combined with auricular acupoint pressing in the treatment of recurrent oral ulcers (皮内针联合耳穴压豆治疗复发性口腔溃疡的效果观察)... by ZHU Yuhua (朱玉华), ZHU Feng (朱凤), LI Doudou (李逗逗), SUN Guifeng (孙贵凤)

“…Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group (100. 00% vs. 83. 33%, P<0. 01). The time to burning pain relief and ulcer healing in the observation group were shorter than those of the control group(P<0. 01). …”
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CLINICAL AND INSTRUMENTAL STUDY RESULTS OF COMPARING DIGITAL OCCLUSION INDICES AT REGISTRATION OF INTERCUSPAL POSITION IN PATIENTS WITH EDENTULOUS SPACES BEFORE AND AFTER PROSTHETI... by Тaras Hlushko, Yuriy Vovk, Volodymyr Vovk, Petro Kryukov, Мaksym Lohash

“…The use of Consiflex resulted in the identical length of joining trajectory and extension of the duration of occlusal joining of teeth after dental prosthetics by 1.04 times. The application of metalized wax was characterized by the identical length of joining trajectory and prolonged occlusion time after dental prosthetics by 1.61 times.…”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…Eighty percent had symptomatic LM, and the median Karnofsky performance scale at LM diagnosis was 80. The median time from primary cancer diagnosis to LM detection was 23.1 months (range, 0-221.3). …”
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Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…Results: Among 18,772 medical cause OHCA cases, the crude incidence rate was 17.4 per 100,000 population, with an age-standardised rate of 38.4. …”
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Effect of Interference Electric Stimulation at Baliao and Dachangshu Acupoints Combined with Mosapride on Constipation Patients with Diabetes by JIANG Huiyu, ZHOU Wei, MING Xiaohong, LIU Haichao, WU Xiuxiang

“…The frequency was (4 000±100) Hz, and the intensity was subject to the patient's tolerance, 20 minutes each time, once a day, continuous treatment for two weeks. …”
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