Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach by Pei Liu, Lin Xu, Jing-han Guo, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Guang-xin Miao, Cui-zhe Liu, Jian-yu Zhou

“…The recoveries of diosgenin and tanshinone IIA were 85.81–100.27% and 98.29%, respectively, with negligible matrix effects. …”
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Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitat... by Mohammad Saiful Islam, Somenath Mitra

“…The incorporation of <i>nf</i>PLGA also reduced the amount of time taken to reach 50% (T₅₀) and 80% (T₈₀) dissolution. …”
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Assessing Soil Erosion by Agricultural and Forestry Production and Proposing Solutions to Mitigate: A Case Study in Son La Province, Vietnam by X. H. Nguyen, A. H. Pham

“…Consequently, the soil erosion has occurred hugely and the time for productive cultivation has been shortened. …”
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Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…This Phase 1, open-label trial randomized healthy adults to receive 62.5 mg/mL sotrovimab IM into each dorsogluteal muscle (2 × 4 mL injections), or 100 mg/mL sotrovimab IM into the dorsogluteal muscle (1 × 5 mL), the anterolateral thigh muscle (1 × 5 mL) or each deltoid muscle (2 × 2.5 mL). …”
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Silver Ecotoxicity Estimation by the Soil State Biological Indicators by S. I. Kolesnikov, N. I. Tsepina, L.V. Sudina, T. V. Minnikova, K. Sh. Kazeev, Yu. V. Akimenko

“…The use of silver in various spheres of life and production leads to an increase in environmental pollution, including soil. At the same time, the environmental consequences of silver pollution of soils have been studied to a much lesser extent than those of other heavy metals. …”
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Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos by Kwesi Boadu Mensah, Charles Benneh, Arnold Donkor Forkuo, Charles Ansah

“…Cryptolepine induced dose- and time-dependent mortality from the 24 to 96 hours postfertilization. …”
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The Validation of the sickle scan technique used to diagnose sickle cell disease by Magain Mihatano Barihuta, Guelord Inkalaba, Jocelyn Kakumba Mankulu, Olivier Nzingula, Maguy Luvandu Mbenza, Nicole M. Misengabu, M Ndeme, Michel Diyi, Mbembe Bitengeli, Tresor Bayebila Menanzambi, Nsimba Miezi, José Lami Nzunzu, Fridolin Kodondi Kule-koto

“…This test can also be applied to samples collected on blotting paper. The interpretation time should not exceed 2 minutes, contrary to the manufacturer's claims. …”
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Advancing breast cancer diagnosis: token vision transformers for faster and accurate classification of histopathology images by Mouhamed Laid Abimouloud, Khaled Bensid, Mohamed Elleuch, Mohamed Ben Ammar, Monji Kherallah

“…Our approach achieved impressive results for both binary and multi-classification of breast cancer subtypes across various magnification levels (40×, 100×, 200×, 400×). The model demonstrated accuracies of 97.02% for binary classification and 93.29% for multi-classification, with decision times of 391.71 and 1173.56 s, respectively. …”
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Assessment of Cellular Responses after Short- and Long-Term Exposure to Silver Nanoparticles in Human Neuroblastoma (SH-SY5Y) and Astrocytoma (D384) Cells by Teresa Coccini, Luigi Manzo, Vittorio Bellotti, Uliana De Simone

“…Cellular response after short-term (4–48 h, 1–100 μg/ml) and prolonged exposure (up to 10 days, 0.5–50 μg/ml) to AgNP was assessed by MTT, calcein-AM/PI, clonogenic tests. …”
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Development of an analytical method for the simultaneous determination of 22 Polycyclic Aromatic Hydrocarbons (PAHs) in maternal and umbilical cord blood by Swiha, Stéphanie, Pichon, Valérie, Fournier, Thierry, Gil, Sophie, Delaunay, Nathalie

“…The aim of this project was to develop a method enabling, for the first time, the simultaneous determination of 22 listed PAHs from small volumes (100 ${\mu }$L) of maternal serum and umbilical cord blood, including a sample pre-treatment reducing as far as possible the quantity of solvents used. …”
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Risk Factors of Upper Limb Lymphedema after Breast Cancer Surgery in Women by Jinghui HUANG, Feng HUANG, Pei ZHU, Shuainan SHEN, Kefan CAO, Cheng LIU, Fanfu FANG, Bai LI

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Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…Chromatographic separation was achieved on XSelecT HSS T3 column by gradient elution with a total run time of 5.0 min. MS detection was performed by a triple quadrupole tandem mass spectrometer in the multiple reaction monitoring mode with a positive electrospray ionization source. …”
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Green synthesis and enhanced photocatalytic performance of Co-Doped CuO nanoparticles for efficient degradation of synthetic dyes and water splitting by Daniel Masekela, Lovedonia K. Kganyakgo, Kwena D. Modibane, Tunde L. Yusuf, Sheriff A. Balogun, Wilson M. Seleka, Edwin Makhado

“…Under UV–vis light irradiation, Co-doped CuO NPs achieved photocatalytic degradation efficiency of about 88 % within 100 min, whereas for pristine CuO NPs it was 75 % under the same irradiation time. …”
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A randomized controlled interventional study for analgesic effects of intrathecal versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine by Manu Dadhwal, Anupama Gupta, Ajay Kurian

“…Materials and Methods: In this prospective, randomized controlled, double-blind study total of 90 patients with the American Society of Anesthesiologists grade I and II were randomly allocated into three groups: Group A (n=30) received IV 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL normal saline, group B (n=30) received IV 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL (5 mcg) dexmedetomidine, and group C (n=30) received IV dexmedetomidine 1 mcg/kg in 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL normal saline. Results: The mean time for two-segment regression in group A was 100.57±4.24 min, in group B it was 193.3±7.07 min, and in group C was 170.23±3.53 min. …”
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Sociodemographic, clinical, and other serological profile of opioid-dependent intravenous drug users infected with hepatitis C virus: A cross-sectional study by Piyush Mahajan, Malvika Dahuja, Manjit Singh, Medi Nagapadma, M Ramasubba Reddy

“…Most of them had tried to quit substances 2 or more times in the form of deaddiction treatment (49%) and had relapsed due to craving. …”
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Exploring bio-remediation strategies by a novel bacteria Micrococcus sp. strain HX in Cr(VI)-contaminated groundwater from long-term industrial polluted by Yu Xia, Yujuan Wen, Yuesuo Yang, Xiaoming Song, Yunlong Wang, Zhipeng Zhang

“…HX was used for the first time to reduce Cr(VI) in groundwater. The reduced ability of HX reached 90.18 % at a Cr(VI) concentration of 100 mg/L, while HX-2 achieved a reduction capacity of 63.8 %. …”
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Treatment Patterns and Health Care Costs in Commercially Insured Patients with Follicular Lymphoma by Nathan H. Fowler, Guifang Chen, Stephen Lim, Stephanie Manson, Qiufei Ma, Frank Li

“…Overall, 598 (100%) patients received first-line therapy, 180 (43.6%) received second-line therapy, 51 received third-line therapy, 21 received fourth-line therapy, and 10 received fifth-line therapy. …”
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Siphon-type hydroelectric plants: application for power generation in a low head dam in southern Brazil by Janaina Terhorst Pizutti, Carlos Henrique Pereira Assunção Galdino, Fernando Setembrino Cruz Meirelles, Alexandre Beluco

“…Two base configurations were considered: one with 100% renewable matrices and another one including a diesel generator. …”
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Participant Contributions to Person-Generated Health Data Research Using Mobile Devices: Scoping Review by Shanshan Song, Micaela Ashton, Rebecca Hahn Yoo, Zoljargal Lkhagvajav, Robert Wright, Debra J H Mathews, Casey Overby Taylor

“…ResultsOut of 3602 publications screened, 100 were included in this review. We observed a rapid increase in all publications from 2016 to 2021, with the largest contribution from US authors, with 1 exception, review articles. …”
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Popcorn Effect–inspired Self‐propagating Formation of High‐conductivity Cement Composite for Multifunctional Applications by Haiping Wu, Jiaqi Huang, Zhengyao Qu, Xueling Zheng, Sirui Tan, Wei Du, Guanming Cai, Zhong Zhao, Jing Wu, Daiqi Li

“…The conductive properties endow the material with excellent electrothermal (>100 °C at 10 V), electrothermochromic (response time of 2 s), and electromagnetic interference shielding (42 dB at 12.4 GHz) performance. …”
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