Relation among zootechnical performance, biochemical indicators, water quality, and small invertebrates (zooplankton) abundance reared in biofloc-supplemented systems by Ahmed Said Al-Souti, Marwa M. Zaher, Amr M. Helal, Dina T. Meshhal, Mansour D. H., Afify D. G. Al-Afify, Mohamed M. Rafaey, Abeer El-Saharty, Ehab El-Haroun, Marian G. Nassif, Abdallah Tageldein Mansour, Abdallah Tageldein Mansour, Mohamed Ashour

“…L−1, respectively, which included four families (Rotifera, Copepoda, Cladocera, and free-living nematodes) with the domination of family Rotifera at 81.65% and 93.89%, respectively. …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

“…Research findings will be shared by the local partner organisations and institutions with relevant stakeholders including youth living with diabetes, policy makers, healthcare workers and the general public. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…All the patients underwent liver transplantation (LT) from a living related donor. The TGF-β1 concentration in plasma was determined using ELISA on average 3 ± 2 days prior to liver transplantation and in the early post-transplant period.Results. …”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…The median age was 54 years (range, 23-79); 73% were female, and 53% lived more than 100 miles from our center. Breast cancer (53%), lung cancer (20%), and melanoma (9%) were the most common primary cancers; 51% of patients had stable systemic disease at LM diagnosis. …”
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Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study by Marcella Warner, Stephen Rauch, Brenda Eskenazi, Lucia Calderon, Robert B. Gunier, Katherine Kogut, Nina Holland, Weihong Guo, Julianna Deardorff, Jacqueline M. Torres

“…We examined the relationship between serum concentrations of persistent organochlorine pesticides and biologic markers of inflammation and cardiometabolic disease, measured over a decade later, in a cohort of middle-aged and primarily immigrant Latina women living in an underserved agricultural community in California. …”
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Combining Innovative Bioink and Low Cell Density for the Production of 3D-Bioprinted Cartilage Substitutes: A Pilot Study by Christel Henrionnet, Léa Pourchet, Paul Neybecker, Océane Messaoudi, Pierre Gillet, Damien Loeuille, Didier Mainard, Christophe Marquette, Astrid Pinzano

“…3D bioprinting offers interesting opportunities for 3D tissue printing by providing living cells with appropriate scaffolds with a dedicated structure. …”
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Monitoring the Concentrations of Na, Mg, Ca, Cu, Fe, and K in <i>Sargassum fusiforme</i> at Different Growth Stages by NIR Spectroscopy Coupled with Chemometrics by Sisi Wei, Jing Huang, Ying Niu, Haibin Tong, Laijin Su, Xu Zhang, Mingjiang Wu, Yue Yang

“…<i>Sargassum fusiforme</i>, an edible seaweed, plays a crucial role in our daily lives by providing essential nutrients, including minerals, to the human body. …”
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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Methods Induced pluripotent stem cell (iPSC)-derived mDANs from PD patients with a monoallelic SNCA locus duplication and unaffected controls were treated with NPT100-18A. αSyn aggregation was evaluated biochemically and reactive oxygen species (ROS) levels were assessed in living mDANs using fluorescent dyes. Adenosine triphosphate (ATP) levels were measured using a luminescence-based assay, and neuronal cell death was evaluated by immunocytochemistry. …”
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A prospective multi-site study to evaluate the performance and usability of an oral fluid-based HIV self-test in Canada by Richard A. Galli, Darshanand Maraj, Kristin McBain, Jason M. Lo Hog Tian, Abbey McFarland, Wangari Tharao, Nontobeko P. Nkala, Arlene Chan, Mark da Silva, Rejean Thomas, Anne-Fanny Vassal, Martin Lepage, Laurie Ireland, Mike Payne, Jared Starr, Chris Fraser, Marion Selfridge, Mona Loutfy, Roberta Halpenny, Nirubini Jeyarajah, Vanessa Tran, Tony Mazzulli, Sean B. Rourke

“…Abstract Background Blood and oral fluid-based HIV self-tests are important for reaching the undiagnosed living with HIV. The study objectives were to evaluate the oral fluid-based OraQuick® HIV Self-Test (HIV-ST) performance in comparison to laboratory reference testing; determine if laypersons can correctly perform the HIV-ST; document if intended users can successfully interpret pre-made contrived positive, negative, and invalid results; and document if intended users can understand the key messages in the product labeling. …”
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Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol by Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh, Siviero Agazzi, Simeng Suy, Brent T. Harris, Susmeeta T. Sharma, Edward Aulisi, Amjad Anaizi, Mohamed H. Khattab, Walter C. Jean, Walter C. Jean, Sean P. Collins, Brian T. Collins

“…Acute toxicity was minimal with eight patients (40%) developing short-lived headaches and one patient (5%) developing a brief ipsilateral sixth nerve palsy. …”
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Prevalence of abnormal bone mineral density and its influencing factors among adult residents in Jiangsu province: a cross-sectional survey by Weihao WANG, Huijing HE, Yaoda HU, Xingming CHEN, Tan XU, Ji TU, Ang LI, Binbin LIN, Qihang LIU, Zhiming LU, Tianshu XI, Haibo HUANG, Da XU, Zhili CHEN, Zichao WANG, Guangliang SHAN

“…MethodsUsing stratified multistage cluster random sampling, we recruited 6 000 adult permanent residents (≥ 20 years old and living locally for at least 5 years) without disability or serious illness and, for women, not pregnant or breastfeeding, in urban and rural areas of Jiangsu province. …”
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Sex-related functional outcome after periacetabular osteotomy in mild to severe hip dysplasia by Maximilian Fischer, Lars Nonnenmacher, Andre Hofer, Alexander Zimmerer, Andreas Nitsch, Rico Großjohann, Sabrina Erdmann, Georgi I. Wassilew

“…The PROMs were assessed using the modified Harris Hip Score (mHHS), the Hip disability and Osteoarthritis Outcome Score (HOOS) with the subscales for pain, sport, activities of daily living (ADL), and quality of life (QoL), and the University of California, Los Angeles (UCLA) activity score. …”
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Relationship between pharmacotherapy for major depressive disorder and healthcare utilisation in British Columbia, Canada: a retrospective population-based cohort by Sonya Cressman, Louisa Edwards, Kimberlyn McGrail, Stirling Bryan, Alison Hoens, Rohit Vijh, Sandra Peterson, Zeina Waheed, Mary Bunka, Nick Pang, Shahzad Ghanbarian, Gavin Wong, Linda Riches, Jehannine Austin

“…Objectives To describe the population that meets the criteria for major depressive disorder (MDD) in British Columbia (BC), compare patterns of healthcare utilisation between those with MDD who are and are not prescribed pharmacotherapy, and assess these relationships in models that control for potential confounding variables.Design We used a population cross-sectional study design among a cohort of individuals living with MDD and examined the relationship between pharmacotherapy and healthcare utilisation between 2019 and 2020 using linked billing and administrative data.Setting This study identified individuals with MDD using a validated case definition of International Classification of Diseases (ICD) codes in BC, Canada.Participants The final study cohort included 549 029 adult participants who met the MDD case definition.Explanatory variable Explanatory variable was the use of prescription antidepressant medication during the study period, based on BC PharmaNet data.Covariates Covariates include sociodemographic characteristics (age, sex, urban/rural residence, neighbourhood income quintile and comorbidities).Primary outcome measure Primary outcome measure was healthcare utilisation (outpatient physician visits, emergency department (ED) visits and hospitalisations).Results We stratified our analysis based on whether study participants were classified as ‘recently incident’ or ‘actively prevalent’. …”
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Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis by Jiang Wang, Jia-Hui Xiang, Xu-Yuan Peng, Min Liu, Le-Jia Sun, Min Zhang, Li-Yuan Zhang, Zhi-Bin Chen, Zheng-Quan Tang, Lei Cheng

“…Severe cases may lead to sleep disorders, anxiety, and depression, subsequently impacting patients’ lives and increasing societal healthcare expenditures. …”
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Land use variation impacts on trace elements in the tissues and health risks of a commercial fish by N.D. Takarina, O.M. Chuan, T.G. Pin, I. Femnisya, A. Fathinah, A.N.B. Ramadhan, R. Hermawan, A. Adiwibowo

“…Copper and zinc in the muscles of fish living on the settlement coasts were 62.69% and 37.18% higher (P <0.05) than fish inhabiting mangrove coasts.CONCLUSION: Trace elements in the commercial fish P. argentata were significantly affected by differences in land use. …”
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Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence by Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

“…In this work, we precisely characterize the interactions of C. auris with the free-living amoeba Acanthamoeba castellanii and how these protozoa may alter the fungal behavior in terms of virulence, thermotolerance, biofilm formation capacity, and drug resistance. …”
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A prospective observational cohort study of HIV infection in Indonesia: baseline characteristics and one-year mortality by Tuti P. Merati, Evy Yunihastuti, Rudi Wisaksana, Nia Kurniati, Dona Arlinda, Muhammad Karyana, Nugroho H. Susanto, Dewi Lokida, Herman Kosasih, Aly Diana, Lois E. Bang, Melinda Setiyaningrum, Desrinawati M. Amin, Eppy Eppy, Wiwit A. S. N. Cahyawati, Emon W. Danudirgo, I Made Gede Darmaja, Nur Farhanah, Carta A. Gunawan, Usman Hadi, Kurnia F. Jamil, Sudirman Katu, Tambar Kembaren, I Gede Rai Kosa, Danang L. Norosingomurti, Asep Purnama, Ida S. Laksanawati, Adria Rusli, I Ketut Agus Somia, Yanri W. Subronto, Ivan L. Toruan, Renee Ridzon, C. Jason Liang, Aaron T. Neal, Ray Y. Chen, INA-PROACTIVE Study Group

“…Despite this progress, AIDS-related deaths among people living with HIV (PLWH) increased from 3.4% in 2010 to 4.8% in 2020. …”
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HIV self-testing positivity rate and linkage to confirmatory testing and care: a telephone survey in Côte d’Ivoire, Mali, and Senegal by Kra, Arsène Kouassi, Fotso, Arlette Simo, Rouveau, Nicolas, Maheu-Giroux, Mathieu, Boily, Marie-Claude, Silhol, Romain, d’Elbée, Marc, Vautier, Anthony, Larmarange, Joseph

“…Two-thirds (65%) went to a general public facility, and one-third to a facility dedicated to key populations.The ATLAS HIVST distribution strategy reached people living with HIV in West Africa. Linkage to confirmatory testing following a reactive HIVST remained relatively low in these first years of HIVST implementation. …”
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Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat by Shellye González-González, Mariana Gutiérrez-Pérez, Mara A. Guzmán-Ruiz, Estefania Espitia-Bautista, Rosa María Pavón, Karla P. Estrada-Rodríguez, Alejandro Díaz-Infante R., Cecilia G. Guadarrama Gándara, Carolina Escobar, Natalí N. Guerrero-Vargas

“…IntroductionAccess to electric light has exposed living organisms to varying intensities of light throughout the 24 h day. …”
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Understanding Dioxygen Activation in the Fe(III)-Promoted Oxidative Dehydrogenation of Amines: A Computational Study by Ricardo D. Páez-López, Miguel Á. Gómez-Soto, Héctor F. Cortés-Hernández, Alejandro Solano-Peralta, Miguel Castro, Peter M. H. Kroneck, Martha E. Sosa-Torres

“…Hydrogenation and dehydrogenation reactions are fundamental in chemistry and essential for all living organisms. We employ density functional theory (DFT) to understand the reaction mechanism of the oxidative dehydrogenation (ODH) of the pyridyl-amine complex [Fe^IIIL³]³⁺ (L³, 1,9-bis(2′-pyridyl)-5-[(ethoxy-2″-pyridyl)methyl]-2,5,8-triazanonane) to the mono-imine complex [Fe^IIL⁴]²⁺ (L⁴, 1,9-bis(2′-pyridyl)-5-[(ethoxy-2″-pyridyl)methyl]-2,5,8-triazanon-1-ene) in the presence of dioxygen. …”
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