1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway by Qiuyun Wu, Chunmeng Jin, Xue Liu, Qianyi Zhang, Biyang Jiao, Hongmin Yu

“…1-Bromopropane (1-BP) has become a new air pollutant in occupational and living environments due to its advantages in industrial applications and as a representative compound of volatile organic compounds (VOCs). …”
Get full text

CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The objective is to recruit 1000 participants (aged 60–99 years) living in the western region of Singapore within a period of 3 years (2018–2020). …”
Get full text

Integrating social narratives of flood events into a text network analysis-based decision support framework to reduce vulnerability to climate change in Africa by Thomas E. O’Shea, Lena C. Grobusch, Mary Zhang, Jeff Neal, Joseph Daron, Richard G. Jones, Christopher Jack, Alice McClure, Gilbert Siame, Dorothy Ndhlovu, Sukaina Bharwani

“…Historical observations and lived experiences were distilled from the learning labs into three community-based social narratives of flood risk. …”
Get full text

Applying YOLOv6 as an ensemble federated learning framework to classify breast cancer pathology images by Chhaya Gupta, Nasib Singh Gill, Preeti Gulia, Noha Alduaiji, J. Shreyas, Piyush Kumar Shukla

“…Early detection is crucial, and the manual screening method may lead to a delayed diagnosis, which would delay treatment and put lives at risk. Mammography imaging is advised for routine screening to diagnose breast cancer at an early stage. …”
Get full text

A patient-led survey on information and communication needs of patients with metastatic breast cancer in Ireland and Northern Ireland (CTRIAL-IE 23–05) by Siobhan Gaynor, Yvonne O'Meara, Emer Mulvaney, Rachel J. Keogh, Catherine S. Weadick, Fran J. Duane, Ann Mc Brien, Helen Greally, Mary Jane O'Leary, Ieva Teiserskyte, Isabel Beristain, Jacinta Marron, Eibhlin Mulroe, Vicky Donachie, Sarah Mc Loughlin, Seamus O'Reilly

“…The routine early provision of palliative care, psycho-oncology, medical social worker and dedicated liaison nurse supports guided by national guidelines and education for healthcare professionals, integrated with living well with cancer clinics and a dedicated medically verified website would provide an ecosystem where MBC care could be optimised for patients and their families.…”
Get full text

Adolescent girls’ explanations of high rates of low mood and anxiety in their population: a co-produced qualitative study by Ola Demkowicz, Rebecca Jefferson, Pratyasha Nanda, Lucy Foulkes, Jo Lam, Steven Pryjmachuk, Rhiannon Evans, Bernadka Dubicka, Liz Neill, Laura Anne Winter, Georgina Nnamani

“…Conclusions The study offers a critically important contribution to evidence on gendered inequalities in low mood and anxiety, drawing attention to the interwoven and complex nature of girls’ lives and illuminating various aspects that would benefit from greater research. …”
Get full text

Identifying Zoonotic Parasites in Domiciled and Non‐Domiciled Dogs (Canis lupus familiaris) Within an Urban Zone of the Eastern State of Mexico by José Salcedo‐Jiménez, Yazmín Alcala‐Canto, Julio Segura‐Tinoco, Ernestina Valadez‐Moctezuma, Juan José Pérez‐Rivero

“…ABSTRACT Background There are over 42 million dogs in Mexico, with a significant population living on the streets, especially in the State of Mexico. …”
Get full text

Fluorescence Lifetime Imaging of NAD(P)H in Patients’ Lymphocytes: Evaluation of Efficacy of Immunotherapy by Diana V. Yuzhakova, Daria A. Sachkova, Anna V. Izosimova, Konstantin S. Yashin, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev, Artem M. Mozherov, Vladislav I. Shcheslavskiy, Marina V. Shirmanova

“…Objective: The aim of the study was to develop a patient-derived glioma explant model enriched by autologous peripheral lymphocytes and explore FLIM of the redox-cofactor NAD(P)H in living lymphocytes to measure the responses of the model to immune checkpoint inhibitors. …”
Get full text

Prevalence, incidence and determinants of QuantiFERONTM positivity in South African schoolchildren by J. Stewart, N. Walker, K. Jennings, C. Delport, J Nuttall, A.K. Coussens, R Dyers, D.A. Jolliffe, J.C.Y. Tang, W.D. Fraser, R.J. Wilkinson, L.-G. Bekker, A.R. Martineau, K. Middelkoop

“…METHODS: We report cross-sectional baseline and prospective incidence data from a large trial among primary school children living in high TB burden communities. Prevalent infection was defined as QuantiFERON™-TB Gold Plus (QFT-Plus) positivity as assessed at baseline. …”
Get full text

Flexible reproductive seasonality in Africa-dwelling papionins is associated with low environmental productivity and high climatic unpredictability by Dezeure, Jules, Dagorrette, Julie, Burtschell, Lugdiwine, Chowdhury, Shahrina, Lukas, Dieter, Swedell, Larissa, Huchard, Elise

“…This study sheds new light on the extent and ecological drivers of flexible reproductive phenology in long-lived tropical mammals, and may even contribute to our understanding of why humans give birth year-round.…”
Get full text

Higher AVCO2 and Lactate Gradient Combined with SOFA Score as a Mortality Predictor during the 6-Hours of Resuscitation of Septic Shock by Morteza Talebi Doluee, Sahar Azam Ghasemzadeh, Ahmad Bagheri Moghadam, Zahra Abbasishaye, Davood Soroosh, Elnaz Vafadar Moradi

“…The mean HR, SBP, and DBP were significantly higher in lived patients; the SOFA scores were significantly lower in these patients. …”
Get full text

Paediatric nephroblastoma at a South African tertiary hospital: A 21-year retrospective analysis by E Brits, E Gerber, I Iroka, L Mgidlana, J Willoughby, S Dhlamini, P Nxumalo, S Sefadi, A Mthembu, J B Sempa

“…Nephroblastoma (Wilms tumour) is one of the most common solid tumours of all paediatric cancers (prevalence of 5% globally and 13.5% in South Africa (SA)), with suboptimal survival outcomes, impacting children’s lives. Consequently, there is an urgent need for enhanced early detection strategies, addressing survival rate disparities and late-stage presentations to improve outcomes. …”
Get full text

Evolution of Self-reported Neuropsychiatric Symptoms After Switching from Dolutegravir/Abacavir/Lamivudine to Bictegravir/Emtricitabine/Tenofovir Alafenamide: Results from the Rand... by Barbara Rossetti, Micol Ferrara, Lucia Taramasso, Francesca Bai, Francesca Lombardi, Nicoletta Ciccarelli, Miriam Durante, Francesca Alladio, Federica Bonazza, Ilaria Rancan, Francesca Montagnani, Antonio Di Biagio, Antonella d’Arminio Monforte, Maurizio Zazzi, Massimiliano Fabbiani, for DOBINeuro study group

“…Methods DOBINeuro is a randomized trial enrolling people living with HIV (PLWH) treated with DTG/ABC/3TC for > 6 months and with HIV-RNA < 50 cps/ml for > 12 months. …”
Get full text

Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…As of 2023, there were 39.9 million people living with Human Immunodeficiency Virus type 1 (HIV-1). …”
Get full text

Construction and validation of a test of knowledge of contraceptive methods for adolescents by Karla Elisa Cervantes Jácome, Silvia Susana Robles Montijo, José Cristóbal Pedro Arriaga Ramírez, Juan José Sánchez Sosa

“…The majority were women (66%), single (88.5%) and lived with their parents (62.9%). Of the 36 initial items, 31 showed discriminatory power between those who performed well on the test and those who did not. …”
Get full text

Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Illiteracy, no spouse, living alone, poor self-reported health, low income, limited meat intake, less exercise, chronic diseases and geriatric syndromes were associated with functional impairment. …”
Get full text

What are the characteristics of disposable electronic cigarettes users in Switzerland? A quantitative study among 14–25 year olds by Luc Lebon, Karin Zürcher, Lorraine Chok, Diana Fernandes-Palhares, Jérémy Cros, Alexandre Dubuis, Cathy Berthouzoz, Yara Barrense-Dias

“…The aim of this study is to determine the prevalence of DEC use among youth (14–25 year olds) living in French-speaking Switzerland and their characteristics.Methods Data were obtained from a web‐based survey conducted in August 2022. …”
Get full text

Effects of tropical cyclone Freddy on the social determinants of health: the narrative review of the experience in Malawi by Joseph Okeibunor, Otim Patrick Cossy Ramadan, Ishata Nannie Conteh, Abdou Salam Gueye, Jayne Byakika-Tusiime, Annie Chauma-Mwale, Ebenezer Obi Daniel, Dick Chamla, Fiona Braka, Neema Kimambo Rusibamayila, Chol Thabo Yur, Emmanuel Maurice Ochien, Mathew Kagoli

“…This step might be useful in improving the vulnerable population’s standard of living and achievement of related Sustainable Development Goals in Malawi.…”
Get full text

Reconstruction of Araucaria araucana cone production reveals warming intensifies regionally synchronized masting by Andrew Hacket‐Pain, Fidel A. Roig, Davide Ascoli, Carlos LeQuesne, Martin Hadad

“…Abstract The reproduction of many long‐lived plants is highly variable and synchronized, known as masting. …”
Get full text

Exome sequencing of UK birth cohorts [version 2; peer review: 2 approved, 1 approved with reservations] by Petr Danecek, Amy Hough, John Wright, Karen Ho, Nicholas J. Timpson, Sarah J. Lindsay, Davide Bonfanti, Daniel S. Malawsky, Rafaq Azad, Deborah Plowman, Sara Widaa, Gemma Shireby, Emla Fitzsimons, David Bann, Matthew E. Hurles, Hilary C. Martin, Susan M. Ring, Dan Mason, Michael A. Quail, Wei Huang, Vivek Iyer, Mahmoud Koko, Iaroslav Popov, Laurie Fabian, Gennadii Zakharov, Ruth Y. Eberhardt, Emma E. Wade, Qin Qin Huang

“…Birth cohort studies involve repeated surveys of large numbers of individuals from birth and throughout their lives. They collect information useful for a wide range of life course research domains, and biological samples which can be used to derive data from an increasing collection of omic technologies. …”
Get full text