Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies by Paula L. Marcet, Brandon Short, Ashley Deas, Hong Sun, Chelsea Harrington, Shahzad Shaukat, Muhammad Masroor Alam, Marycelin Baba, Adedayo Faneye, Prossy Namuwulya, Lea Necitas Apostol, Tamer Elshaarawy, John Kofi Odoom, Peter Borus, Shelina Moonsamy, Yogolelo Riziki, Marie Claire Endegue Zanga, Mesfin Tefera, Anfumbom K. W. Kfutwah, Salmaan Sharif, Varja Grabovac, Cara C. Burns, Nancy Gerloff

“…ABSTRACT In the Global Polio Laboratory Network (GPLN), poliovirus (PV) screening results from acute flaccid paralysis (AFP) surveillance is based on virus isolation (VI) through cell culture, entailing long turnaround times and the amplification of live poliovirus. An alternative Direct Detection strategy (DD-ITD) for screening viral nucleic acid from stools, bypassing the need for virus culture, has been developed and extensively validated by GPLN partners. …”
Get full text

Immunogenicity and safety of a COVID-19 DNA vaccine in healthy adults and elderly: A randomized, observer-blind, placebo-controlled phase 2 trial by Siyue Jia, Chengwei Shao, Xin Cheng, Hongxing Pan, Zhijian Wang, Yu Xia, Jianfang Xu, Xuefen Huai, Danjing Leng, Jiarong Wang, Gan Zhao, Bin Wang, Jingxin Li, Fengcai Zhu

“…The primary immunogenicity endpoints focused on determining the geometric mean titers (GMTs) of spike-binding antibodies and live SARS-CoV-2 neutralizing antibody at day 30 after the second dose. …”
Get full text

Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…Upon withdrawal of doxycycline, this monoclonal microglial cell line differentiates, resembling in vivo microglial physiology as demonstrated by the expression of microglial genes, innate immune responses, chemotaxis, and phagocytic abilities. We utilized live imaging and various molecular techniques to functionally characterize the clonal 2E11murine microglial cell line. …”
Get full text

Metabolic disorders as a factor in pathogenesis of infectious diseases in cattle by A. D. Alekseev

“…The product was injected subcutaneously at a dose of 0.025 ml/kg of live weight to cows in late gestation and calves showing mild anemia, low red blood cells counts, leukocytosis, high lymphocyte and monocyte counts and elevated erythrocyte sedimentation rate, which suggest inflammatory processes in the animal body. …”
Get full text

Choanal Atresia: Clinical Features and Factors Affecting Its Surgical Outcomes by Abhilasha Somashekhar, Prem Kumar, Sandhya Poothatta Manolikandy, Syed Mohammed Shoib

“… Introduction: One of a rare congenital anomaly seen in the development of nose is choanal atresia, whose occurrence is 1 in 5000-8000 live births. This study highlights our experiences in the management of choanal atresia. …”
Get full text

Problems of decentralized disaster management in Indonesia: A review of local government failures by Fatkul Fikri Ahmad, Rustian, Afifuddin Mohammad, Ruswandi Dody, Susilo Rahardi Catur, Albright Sumange Andi

“…Thus, the implementation of decentralization of disaster management, which aims to increase citizens’ disaster awareness, keep people away from disaster risk, and make people able to live side by side with disasters, has not been maximally realized.…”
Get full text

Analysing the Demography and Migration Related Challenges within the Internal Periphery of South-Heves by Tunde Bogardi

“…The future of the affected regions, settlements is largely determined by the perspectives perceived by young people who live there, and who shall start their families and careers there in the near future. …”
Get full text

Pseudodynamic Testing of Buildings Retrofitted with External Steel Reinforced Concrete Frames to Increase Lateral Strength for Earthquake Damage Prevention by Ju-Seong Jung, Kang-Seok Lee

“…The retrofitting method developed in this study can be used to perform seismic strengthening construction, while residents continue to live within the building. The method is categorized as a “strength design approach” implemented via retrofitting, allowing the lateral ultimate load capacity of RC buildings, whose failure mode is shear, to be increased easily. …”
Get full text

Intestinal Myiasis Caused by Sarcophaga spp. in Cusco, Peru: A Case Report and Review of the Literature by Priscilla Ly, Adiel Aizenberg, Taylor Martin, Martha Lopez, Miguel Arturo Saldaña, Grant Leslie Hughes, Miguel Mauricio Cabada

“…The larvae can infect living or necrotic tissue involving the skin, nasopharynx, genitourinary, and gastrointestinal tracts. …”
Get full text

Investigation of Selected Companies' Websites for Online Recruitment and Sustainability Indicators by Gamze Ay, Hasan Tutar

“…Online platforms should be established to access and communicate employee and potential employee candidates to Human Resources. The era we live in is called the information age and the most important concept defining this era is change and the increase in the speed of change. …”
Get full text

Pregnancy Outcomes of Infertile Patients Presenting to Our Assisted Reproductive Technology Center by Hasan Ali Inal, Zeynep Ozturk Inal

“…While a statistically significant difference was observed in fertilization rate (p<0.05), the following were comparable between the groups (p>0.05): number of retrieved and MII oocytes, two pronuclei, day of transfer, embryo transfer technique, single vs. multiple embryo transfer, rates of the Grade-I embryo, biochemical and clinical pregnancy, live birth, ectopic pregnancy, and miscarriage. …”
Get full text

Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice by Fernanda S. Oliveira, Natalia B. Carvalho, Dario S. Zamboni, Sergio C. Oliveira

“…Here, we demonstrated that macrophages from NOD1-, NOD2-, and Rip2-deficient mice produced lower levels of TNF-α following infection with live Brucella abortus compared to wild-type mice. …”
Get full text

Partner Choices in Long Established Migrant Communities in Belgium by Emilien Dupont, Amelie Van Pottelberge, Bart Van de Putte, John Lievens, Frank Caestecker

“…We focused on the role of migration history and transnational links, culture (religion, language), skin colour and structural characteristics of the district migrants live in (mainly community size) to gain further insight into the partner choices of migrants in Belgium. …”
Get full text

Efficacies of corynebacterium pseudotuberculosis vaccines against caseous lymphadenitis in mice and sheep by Osman Erganiş, H. Hüseyin Hadimli, Kürşat Kav, Aslı Sakmanoğlu, Zafer Sayın, Yasemin Pınarkara

“…But, the lower ratio of morbidity and mortality in challenged trials with live bacteria were determined in the groups of bacterin and combined. …”
Get full text

We Now Have the Tools and Infrastructure to Hold Donors and NGOs in International Development to their Own Legal and Professional Standards by David H. Lempert

“…Findings: The piece offers some reflections on the world that we live in where international standards and universal principles are not applied, where legal codifications for international development are not enforced, and where current international development approaches are leading to unsustainability, conflict, and homogenization (suppression of human diversity and adaptation) that the standards were designed to help avoid. …”
Get full text

A Machine Learning-Based Platform for Monitoring and Prediction of Hazardous Gases in Rural and Remote Areas by Edgar F. Ladeira, Bruno M. C. Silva

“…In these areas, access to security and health services is scarce, and real-time monitoring of citizens and the conditions in which they live is very difficult. Without means to monitor or predict, healthcare and government stakeholders typically act too late when indoor incidents occur. …”
Get full text

SOCIAL CONSTRUCTIVISM AS A SOLUTION TO RATIONALITY IN POSTNONCLASSICAL EPISTEMOLOGY by O. V. Molokova

“…Features of modern constructivism − in a special sight at knowledge, in a new foreshortening of its consideration when it represents itself as the tool of maintenance of ability to live of an organism as integrity (the individual, social group, a society). …”
Get full text

ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps by J. Cuneo, L. Barboni, N. Blanco, M. del Castillo, J. Quagliotti

“…The robot freely explores a limited laboratory area in the manner of a rat or mouse and reports information to a PC, thus enabling research without the use of live individuals. Position coordinate neural maps are achieved as mathematically predicted although for a reduced number of implemented neurons (i.e., 200 neurons). …”
Get full text

ADAPTIVE FEATURES OF THE VEGETATIVE ORGANS OF SOME COMMON RIPARIAN PLANTS IN THE LOWER HA THANH RIVER, NHONBINH WARD, QUYNHON CITY, BINHDINH PROVINCE by Dương Tiến Thạch, Hoàng Lương Giang

“…The plant species which live in the lower Ha Thanh river, Binhdinh province, have some morphological and anatomicaladaptations to the riparianenvironment. …”
Get full text

Exploration of Flood Prediction in Watersheds Based on the Fusion Analysis of Remote Sensing Big Data with Multiple Physical Fields by Minming Xu, Yun Ouyang

“…More than half of the people in China live in flood-prone areas, and their lives and properties are threatened. …”
Get full text