Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes by Richard G. Peterson, Charles V. Jackson, Karen Zimmerman, Willem de Winter, Norman Huebert, Michael K. Hansen

“…ZDSD rats will provide a novel, translational animal model for the study of human metabolic diseases and for the development of new therapies.…”
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Mesenchymal Progenitors Derived from Different Locations in Long Bones Display Diverse Characteristics by Weiguang Lu, Bo Gao, Jing Fan, Pengzhen Cheng, Yaqian Hu, Qiang Jie, Zhuojing Luo, Liu Yang

“…Overall, our results provide strong evidence for the importance of selecting the appropriate source of skeletal progenitors for applications in future skeleton regeneration therapies.…”
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Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction by Junrui Xu, Ussama Sadiq, Wangruizhi Zhao, Hengbo Xia, Yiwei Liu, Renquan Zhang, Aman Xu

“…Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.MethodsWe employed single-cell RNA sequencing to analyze the tumor heterogeneity and microenvironmental landscape in patients with AEGJ liver metastases. …”
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Reducing M2 macrophage in lung fibrosis by controlling anti-M1 agent by Fatemeh Bahram Yazdroudi, Alaeddin Malek

“…This study underscores the significance of targeting M2 macrophages and employing mathematical methods to develop innovative therapies for lung fibrosis.…”
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Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening by Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell

“…Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan-coronavirus activity are of high interest. …”
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Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> by Julia Tortajada-Pérez, Andrea del Valle Carranza, Cristina Trujillo-del Río, Mar Collado-Pérez, José María Millán, Gema García-García, Rafael Pascual Vázquez-Manrique

“…The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.…”
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Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma by Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Ioana Anca Badarau, Andreea-Elena Scheau, Mircea Tampa, Simona Roxana Georgescu, Andreea Cristiana Didilescu, Cristian Scheau, Constantin Caruntu

“…Hepatocellular carcinoma (HCC) is the most common primary liver cancer and affects about 8% of cirrhotic patients, with a recurrence rate of over 50%. There are numerous therapies available for the treatment of HCC, depending on cancer staging and condition of the patient. …”
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The Challenges of ST-Elevation Myocardial Infarction in COVID-19 Patients by Ju Young Bae, Khalil Ian Hussein, Christopher John Howes, John Francis Setaro

“…Data was collected via manual chart review and included patient demographics, comorbidities, laboratory tests, electrocardiogram (ECG) results, echocardiography results, diagnoses during hospitalization, inpatient therapies, and outcomes including length of hospital stay, revascularization results, and mortality. …”
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The Link Between Gut Microbiota and Depression: Exploring the Correlation by Adam Juśkiewicz, Olga Grelewicz, Natalia Kucy, Elwira Servaas, Mateusz Haber, Paula Kula, Adrianna Czachor, Alicja Kotula

“…Further research is needed to optimize therapeutic approaches, explore personalized medicine strategies based on individual microbiome profiles and clarify the safety and efficacy of microbial-based therapies in clinical settings. …”
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Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…Despite the widespread occurrence of fibrotic diseases, effective therapies are lacking. Recent clinical studies have demonstrated a positive correlation between serum homocysteine (Hcy) levels and the severity of systemic sclerosis. …”
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Distinguishing rheumatoid arthritis from psoriatic arthritis by Joseph F Merola, Luis R Espinoza, Roy Fleischmann

“…Differences in the pathogenesis of RA and PsA translate into some variances in the specificity and efficacy of therapies.…”
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Tumor-Associated Mast Cells in Thyroid Cancer by Carla Visciano, Nella Prevete, Federica Liotti, Gianni Marone

“…There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies. Among the different cell populations that infiltrate cancer stroma, mast cells (MCs) can influence several aspects of tumor biology, including tumor development and progression, angiogenesis, lymphangiogenesis, and tissue remodelling. …”
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The Early Expression of HLA-DR and CD64 Myeloid Markers Is Specifically Compartmentalized in the Blood and Lungs of Patients with Septic Shock by Tomasz Skirecki, Małgorzata Mikaszewska-Sokolewicz, Grażyna Hoser, Urszula Zielińska-Borkowska

“…Identification of reliable biomarkers is key to guide targeted therapies in septic patients. Expression monitoring of monocyte HLA-DR and neutrophil CD64 could fulfill the above need. …”
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Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals by Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane

“…Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses. …”
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Current Status, Challenges, Policies, and Bioethics of Biobanks by Byunghak Kang, Jaesun Park, Sangyun Cho, Meehee Lee, Namhee Kim, Haesook Min, Sooyoun Lee, Ok Park, Bokghee Han

“…The main aim of the biobank is to store and to maintain biomaterials for studying chronic disease, identifying risk factors of specific diseases, and applying personalized drug therapies. This report provides a review of biobanks, including Korean biobanks and an analysis of sample volumes, regulations, policies, and ethical issues of the biobank. …”
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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review by M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques, M. Lima

“…We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies. Case Presentation. A European 36-year-old male presented with acute onset fever, pallor, weakness, and jaundice. …”
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Development of animal models to study aggressive thyroid cancers by Shovan Dutta, Jeffrey A Knauf

“…These models provide important preclinical tools to explore how cooperating alterations influence the response to therapies, particularly those targeting the oncogenic driver. …”
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A Dermal Piercing Complicated by Mycobacterium fortuitum by Trisha Patel, Leslie Scroggins-Markle, Brent Kelly

“…We recommend a high level of suspicion for atypical mycobacterial infections in a piercing resistant to other therapies.…”
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Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health by Jacopo Logiudice, Maria Alberti, Andrea Ciccarone, Benedetta Rossi, Giorgio Tiecco, Maria Antonia De Francesco, Eugenia Quiros-Roldan

“…However, the lack of both targeted antiviral therapies and vaccines for many arboviruses, together with undetected or asymptomatic cases, hamper containment efforts. …”
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Potentials of Curcumin as an Antidepressant by S.K. Kulkarni, Ashish Dhir, Kiran Kumar Akula

“…Despite the availability of these blockbuster molecules, approximately 30% of depressed patients do not respond to the existing drug therapies and the remaining 70% fails to achieve complete remission. …”
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