The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“…Current pharmacological treatments, including cholinesterase inhibitors and NMDA receptor antagonists, provide only symptomatic relief and fail to alter disease progression. Emerging therapies, such as monoclonal antibodies targeting amyloid-beta and tau proteins, show promise but are hindered by challenges in efficacy and safety. …”
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A phytotherapeutic approach to hinder the resistance against clindamycin by MRSA: in vitro and in silico studies by Amal Mayyas, Ali Al-Samydai, Nehaya Al-Karablieh, Waleed A Zalloum, Deniz Al-Tawalbeh, Farah Al-Mamoori, Rula A. Amr, Hamdi Al Nsairat, Simone Carradori, Lidia Kamal Al-Halaseh, Talal Aburjai

“…Molecular docking studies confirmed trans-cinnamaldehyde’s strong binding to MRSA’s AgrA protein, elucidating its enhanced efficacy.Conclusion The study underscores the potential of plant-based therapies to augment the effectiveness of conventional antibiotics like clindamycin in combating MRSA and addressing antibiotic resistance by integrating traditional plant remedies with modern medical approaches.…”
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Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and no... by Zhirui Zhang, Wenhuan Song, Wenyu Chen, Wenze Cui, Wenyi Chen, Qinheng Zhang, Wenwen Ji, Yinglin Wang, Jiayi Wang, Wenhao Yu, Mingkun Yu, Mingkun Yu, Tao Hao, Hong Jiang

“…Future research should focus on miRNA’s role in drug resistance and combination therapies to accelerate its clinical translation.…”
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Unloader brace or high tibial osteotomy in the treatment of the young patient with medial knee osteoarthritis: a randomized controlled trial by Mark Stam, Joost Verschueren, Mark V van Outeren, Reinoud W Brouwer, Robert D A Gaasbeek, Sorin G Blendea, Eline M van Es, Max Reijman, Sita M A Bierma-Zeinstra

“…Two widely applied unloading therapies are a valgus unloader brace and a high tibial osteotomy (HTO). …”
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Research progress and application status of organoid in breast cancer subtypes by Qiuxia Zhang, Min Wang, Li You, Chen Chen, Jia Feng, Miao Song, Kui Yang, Xuexue Liu, Guangrong Li, Jinbo Liu

“…This review will examine the challenges and future prospects of organoid models in BC research, offering new insights into the fundamental mechanisms of BC and paving the way for more effective personalized therapies. …”
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Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? by Krishna D. Bharwani, Maaike Dirckx, Dirk L. Stronks, Willem A. Dik, Marco W. J. Schreurs, Frank J. P. M. Huygen

“…This could pave the way for new anti-inflammatory therapies in the treatment of CRPS. Furthermore, sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS.…”
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Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD; however, these drugs are not curative. …”
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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

“…VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in oncology. …”
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NOSOCOMIAL INFECTIONS IN PATIENTS WITH UROLITHIASIS IN THE POSTOPERATIVE PERIOD by F. S. Sadulloev

“…The diagnosis of nosocomial infections on the basis of established symptomatic urinary tract infection, asymptomatic bacteriuria or the presence of wound infection, use during the hospital stay for treatment of antibiotics, antiseptics, physiotherapy and other therapies. The incidence of nosocomial infections was studied in dependence with the severity of the underlying disease, the volume of surgical, invasive, endoscopic and other urological procedures, the timing and frequency of tests, the proportion of individual clinical manifestations in the overall structure of urinary tract infections, sex and age of patients.Conclusions. …”
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Inhibiting Autophagy by Chemicals During SCAPs Osteodifferentiation Elicits Disorganized Mineralization, While the Knock-Out of <i>Atg5/7</i> Genes Leads to Cell Adaptation by Damien Le Nihouannen, Claudine Boiziau, Sylvie Rey, Nicole Agadzhanian, Nathalie Dusserre, Fabrice Cordelières, Muriel Priault, Helene Boeuf

“…They have multipotent differentiation capabilities and are a potentially powerful model for investigating strategies of clinical cell therapies. Since autophagy—a regulated self-eating process—was proposed to be essential in osteogenesis, we investigated its involvement in the SCAP model. …”
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Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases by Nargish Parvin, Sang Woo Joo, Tapas K. Mandal

“…This review provides a comprehensive analysis of state-of-the-art biodegradable nanocarriers such as polymeric nanoparticles, liposomes, and hydrogels engineered for targeted delivery in autoimmune therapies. These nanomaterials are designed to degrade safely in the body while releasing therapeutic agents in response to specific stimuli, including pH, temperature, redox conditions, and enzymatic activity. …”
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Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells by Roberta Santarelli, Paola Currà, Michele Di Crosta, Roberta Gonnella, Maria Saveria Gilardini Montani, Mara Cirone

“…Interestingly, curcumin also reduced mutp53 expression, suggesting that it could enhance the efficacy of other therapies, particularly in overcoming drug resistance mechanisms associated with mutp53. …”
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The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities by Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin

“…Given these intricate dynamics, therapies targeting senescence hold promise for advancing antitumor strategies. …”
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Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis by J.H. Shazia Fathima, Selvaraj Jayaraman, Asma Abdullah Nurul, Ramya Sekar, Inamul Hasan Madar, Logalakshmi Thirumani, Nazmul Huda Syed

“…Integrating miRNA-based techniques into precision medicine offers personalized therapeutic avenues, considering ethnic and environmental factors. MiRNA-targeted therapies, potentially combined with conventional approaches, show promise in addressing OSMF complexities. …”
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Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions by Ana Josefina Monjarás-Ávila, Louis Hardan, Carlos Enrique Cuevas-Suárez, Norma Verónica Zavala Alonso, Miguel Ángel Fernández-Barrera, Carol Moussa, Jamal Jabr, Rim Bourgi, Youssef Haikel

“…White spot lesions, the earliest stage of caries, compromise enamel’s esthetics and integrity. Remineralization therapies, both fluoride and non-fluoride based, aim to restore enamel, but limited comparative data exist on their effects on lesion depth and microhardness. …”
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Dialysate White Blood Cell Change after Initial Antibiotic Treatment Represented the Patterns of Response in Peritoneal Dialysis-Related Peritonitis by Pichaya Tantiyavarong, Opas Traitanon, Piyatida Chuengsaman, Jayanton Patumanond, Adis Tasanarong

“…Clinicians should focus on the delayed response and failure patterns in order to make a decision whether to continue medical therapies or to aggressively remove the peritoneal catheter.…”
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Novel Therapeutic Approaches to the Treatment of Chronic Abdominal Visceral Pain by Franca Patrizi, Steven D. Freedman, Alvaro Pascual-Leone, Felipe Fregni

“…This paper will present an overview of the pathophysiology and the available therapies for CAVP, focusing on the recent advances in the treatment of this pathology.…”
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A critical period for paired-housing-dependent autistic-like behaviors attenuation in a prenatal valproic acid-induced male mouse model of autism by Jian-Quan Yang, Bao-Qi Yin, Chao-Hua Yang, Miao-Miao Jiang, Zhe Li

“…However, there remain unsolved issues of behavioral intervention such as the appropriate time and types of therapies. In this study, we employed a mouse model prenatally exposed to valproic acid to establish a validated ASD mouse model and We found that paired-housing with control mice for 4 week after weaning palliated sociability deficits, anxiety and repetitive behaviors in this model of ASD-like behaviors, while paired-housing with their ASD littermate did not produce this effects. …”
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Canadian Helicobacter pylori Consensus Conference Update: Infections in Adults by RH Hunt, CA Fallone, ABR Thomson, Canadian Helicobacter Study Group

“…Key changes included the following: the recommendation for testing and treating H pylori infection in patients with known peptic ulcer disease was extended to testing and treating patients with ulcer-like dyspepsia; it was decided that the urea breath test (not serology) should be used for routine diagnosis of H pylori infection unless endoscopy is indicated for another reason; and recommended therapies were a twice daily, seven-day regimen of a proton pump inhibitor (omeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg) or ranitidine bismuth citrate 400 mg, plus clarithromycin 500 mg and amoxicillin 1000 mg, or plus clarithromycin 500 or 250 mg and metronidazole 500 mg. …”
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Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma by Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

“…These data provide avenues for novel therapeutic approaches that could combine CD175- and CA19-9-targeting therapies for PDAC patients.…”
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