Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. Here, we introduced the definition and advantages of organoids and described the development and advances in hepatobiliary organoids research. …”
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Novel classification system and high-risk categories of pediatric acute myeloid leukemia by Masayuki Umeda, Yen-Chun Liu, Seth E. Karol, Jeffery M. Klco

“…Molecular categories in the new classification system are associated with unique transcriptional, mutational, and clinical characteristics, which can be leveraged for predicting clinical outcomes and developing molecular-target therapies based on the initiating driver alterations. …”
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Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity by Nathan E. Esplin, John W. Stelzer, Timothy B. Legare, Sayed K. Ali

“…This case represents a case of a rare disease that was refractory to all known therapies. It outlines the need for further understanding of this disorder in order to provide better symptomatic treatment or potentially more definitive care.…”
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Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells by Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, Frances Henson

“…In conclusion, PBMCs increase both MSC migration and differentiation suggesting that they are an ideal candidate for inclusion in regenerative medicine therapies aimed at cartilage repair.…”
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Experimental Study of Irinotecan Induced Side Effects on Digestive and Immune System of Mice by Liya LIU, Thomas Joseph SFERRA, Senthilkumar SANKARARAMAN, Youqin CHEN

“…Body weight, diarrhea index, spleen index, thymus index, complete blood count and pathological changes of the jejunum, ileum and colon were measured on the second day and the fourth day after CPT-11 intervention.Results:Compared with the control group, mice body weight was decreased significantly on the second day and the fourth day upon CPT-11 intervention while diarrhea index was increased (<italic>P</italic>&lt;0.05); CPT-11 intervention also decreased spleen index, thymus index (<italic>P</italic>&lt;0.05), white blood cell count and neutrophil count profoundly along with significant jejunum, ileum and colon injury of the mice.Conclusion:CPT-11 can induce side effects about the digestive and immune system, which consistents with the clinical side effects of CPT-11, and this will be helpful for the further development of novel supplementary therapies for CPT-11 induced toxicity.…”
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RhoA Regulation of Cardiomyocyte Differentiation by Mari Kaarbø, Denis I. Crane, Wayne G. Murrell

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Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen by Gokhan Duruksu, Aysegul Aciksari

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La prévention anti infectieuse au cours des greffes de cellules souches hématopoïétiques by Mohammed Amine Bekadja

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Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19 by Ali Tavoosian, Sana Ahmadi, Seyed Mohammad Kazem Aghamir

“…During the COVID-19 pandemic, in case of abnormal clinical manifestations of COVID infection and inadequate therapeutic response to the routine therapies, this disease with unusual manifestations should be considered. …”
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The impact of the first wave of the COVID-19 pandemic on hospital admissions and treatment management of ectopic pregnancy by Hande Gurbuz, Gulfem Basol, Mehmet Mustafa Altintas, Betul Kuru

“…Furthermore, surgical treatment methods were used more than conservative therapies during the outbreak.…”
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Advancements of Deep Learning Model-Based Rehabilitation Training System by Xu Chiyu

“…Traditional therapies for rehabilitation training in modern society are difficult to track patients dynamically, so this paper introduces a rehabilitation training evaluation system under deep learning modeling to help assess the effectiveness of rehabilitation training. …”
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Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin bar... by Jingyan Guan, Kaiqi Chen, Feng Lu, Yunfan He

“…Atopic dermatitis (AD) is a chronic relapsing dermatosis that demands new therapies. This research group previously developed a physically extracted adipose-derived extracellular matrix named adipose collagen fragments (ACF), which was determined containing massive adipose matrix-bound adipokines and medicable on AD through intradermal injection. …”
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Prognostic Factors and Outcome of Patients with Adult Acute Lymphoblastic Leukemia Treated with the Hyper-CVAD Regimen: A Retrospective Study by Zahra Malakoutikhah, Farzaneh Ashrafi, Ali Derakhshandeh

“…The outcome of the traditional Hyper-CVAD regimen in treating adult ALL was not satisfying. More efficient therapies should be applied for the treatment of adult ALL.…”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…This review delves into the molecular underpinnings of psoriasis, examining current therapies and promising investigational agents. We highlight the potential of nanotechnology to enhance drug delivery to affected skin areas, with microneedles emerging as a promising platform for psoriasis and other chronic inflammatory skin diseases.Keywords: biodegradable nanoparticles, clinical trials, skin inflammatory diseases, psoriasis, microneedles…”
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Navigating the Evolving Treatment Paradigm for _EGFR_-Mutant NSCLC by Sebastian Kraus

“…Given the many treatment options available for NSCLC and the increasing understanding of the interactions between mutations and common therapies in the palliative stages, comprehensive next-generation sequencing (NGS) is recommended at the initial stage, particularly for adenocarcinomas. …”
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La prévention anti infectieuse au cours des greffes de cellules souches hématopoïétiques by Mohammed Amine Bekadja

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Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. …”
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Multimodality Imaging of Endothelial Progenitor Cells with a Novel Multifunctional Probe Featuring Positive Magnetic Resonance Contrast and Near-Infrared Fluorescence by Shenghong Ju, Yiru Qiu, Cong Li, Gao-Jun Teng, Yicheng Ni

“…The multimodal strategy incorporating T 1 -weighted magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescence imaging can complement their strengths to provide images with high sensitivity and spatial resolution for noninvasively and dynamically monitoring endothelial progenitor cells (EPCs) in potential EPC-dominated therapies. Here we report the development of a protein-based imaging probe, bCD-PLL-Cy5.5 Conjugate 1, in which the bacterial cytosine deaminase (bCD) protein was modified with poly- l -lysine (PLL) that is labeled with imaging reporters, including T 1 -weighted MRI contrast chelator and NIR fluorophore. …”
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A Bayesian tool for optimizing sample size in phase I dose-finding trials for head and neck cancer by Sivakamavalli Jeyachandran

“…As oncology evolves toward precise and personalized treatments, Bayesian methods will play a crucial role in advancing clinical trial design, particularly in Phase I dose-finding trials for head and neck cancer, enhancing the development of next-generation cancer therapies.…”
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Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation by Dongdong Liu, Pu Mao, Yongbo Huang, Yiting Liu, Xiaoqing Liu, Xiaoqing Pang, Yimin Li

“…In conclusion, our findings provide a global alteration in the proteome of lung tissues in the ALI rat model and indicate that PRDX1 may play a critical role in the pathogenesis of ARDS by promoting inflammation and represent a novel strategy for the development of new therapies against ALI.…”
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