Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration by Huinan Zhang, Dongchao Ji, Kunlong Zhao, Zhuoheng Li, Shuo Yang, Peng Wang, Wenxin Cao, Yu Sun

“…In conclusion, PLGA/PVA controlled-release nanofiber membranes loaded with antibacterial drugs offer great promise for bone tissue regeneration therapies.…”
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Prediction of biochemical prostate cancer recurrence from any Gleason score using robust tissue structure and clinically available information by Laura E. Marin, Daniel I. Zavaleta-Guzman, Jessyca I. Gutierrez-Garcia, Daniel Racoceanu, Fanny L. Casado

“…Abstract Biopsy information and protein Prostate-Specific Antigen (PSA) levels are the most robust information available to oncologists worldwide to diagnose and decide therapies for prostate cancer patients. However, prostate cancer presents a high risk of recurrence, and the technologies used to evaluate it demand more complex resources. …”
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Three Prospective Case Studies Examining Mifepristone’s Efficacy in Patients with Treatment-Resistant PTSD by Agnes van Minnen, Lizelotte Vos, Pierre M. Bet, Ad de Jongh, Felix Linsen, Hein J. F. van Marle, Onno C. Meijer, Willem M. Otte, Marije Russcher, Christiaan H. Vinkers

“…Despite the availability of various treatment approaches for patients with posttraumatic stress disorder (PTSD), some patients do not respond to these therapies, and novel treatment approaches are needed. …”
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Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types by Jessie M. Vo, Linh M. La, Ananda V. Anderson, Abdulaziz H. Alanazi, Payaningal R. Somanath

“…Abstract Cancer is a complex disease with profound societal and economic impacts, especially in metastatic cases where treatment challenges arise due to the absence of reliable biomarkers and effective therapies. While P21‐activated kinases (PAKs) play a key role in cancer progression, their potential as predictive markers for metastasis and therapeutic targets has not been fully explored. …”
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…By deciphering the molecular fingerprint of cells treated with therapies targeting translation we identify a rational approach to select broad-spectrum antivirals with potential to counteract future pandemic viruses.…”
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Ultrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds by Yitao Zhao, Yong Tan, Chun Zeng, Weilun Pan

“…Moreover, the HDG hydrogel provides a dual antibacterial mechanism through chemical and photothermal therapies via the generated PDA, significantly improving bacterial clearance. …”
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An Optimal Algorithm for Determining Risk Factors for Complex Diseases: Depressive Disorder, Osteoporosis, and Fracture in Young Patients with Breast Cancer Receiving Curative Surg... by Chieh-Yu Liu, Chun-Hung Chang

“…The results revealed that depressive disorder, osteoporosis, and fracture were clustered with liver cirrhosis, chronic obstructive pulmonary disease (COPD), distant metastasis, and primary metastatic and adjuvant therapies, namely, chemotherapy, radiotherapy, tamoxifen, aromatase inhibitors, and trastuzumab. …”
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Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango by Vinay Kumar, Shyam S. Bansal

“…The aims of this review are to (i) briefly summarize the role of key immune cells that regulate wound healing during MI and fibrosis during LV remodeling; (ii) underscore phenotypic diversities in immune cells and their subsets to underscore their role in regulating fibrotic responses, and, last but not the least, (iii) highlight gaps in our understanding that restrict the translation of immuno-modulatory therapies from the preclinical models to heart failure patients.…”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…Abstract Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…The more aggressive triple-negative and HER2-positive breast cancer subtypes are overrepresented in inflammatory breast cancer compared with noninflammatory breast cancer, with a poorer prognosis in response to conventional therapies. Despite its name, there remains some controversy regarding the role of inflammation in inflammatory breast cancer. …”
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Late Onset Atypical Pantothenate-Kinase-Associated Neurodegeneration by Natalie Diaz

“…Optimal treatment strategies are not known, and at the current time therapies should be directed at the specific manifestations of the disease.…”
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The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection by Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova

“…The importance of studying the properties of proviral reservoirs is connected with the inaccessibility of integrated HIV proviral DNA for modern anti-retroviral therapies (ARTs) that block virus reproduction. If treatment is not effective enough or is interrupted, the proviral reservoir can reactivate. …”
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Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide by Sarah L. Newstead, Amanda J. Gates, M. Gillian Hartley, Caroline A. Rowland, E. Diane Williamson, Roman A. Lukaszewski

“…Understanding how F. tularensis interacts with host macrophages will help in the rational design of new and effective therapies.…”
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Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives by Makoto Naganuma, Mitsuhiro Takeno, Aykut Ferhat Çelik, Robert Moots, Philippe Pinton, Tadakazu Hisamatsu

“…., tumor necrosis factor α and interleukin-6 (IL-6), which could serve as a target for potential therapies. This review provides an overview of GIBD, including the diagnosis and immunopathogenesis as it is currently understood, and evaluates the emerging role of the inhibition of IL-6 (classic and trans-signaling) as an alternative treatment option for patients with GIBD. …”
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Structural and Functional Characterization of Deceased Donor Stem Cells: A Viable Alternative to Living Donor Stem Cells by Prakash N. Rao, Dayanand D. Deo, Misty A. Marchioni, Rouzbeh R. Taghizadeh, Kyle Cetrulo, Sharyn Sawczak, Jacob Myrick

“…This will offer increased accessibility for patients awaiting stem cell therapies.…”
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Oxidative impact on lipoprotein structure: Insights from dynamic light scattering by Nickolette Kong, Natalia Penaloza, Gustavo Agreda, Angela B. Nguyen, Joseph Gutheinz, Alison Tran, Nhi Nguyen, Tuong Vi Ho, Ana Marin, Birgit Mellis, Richa Chandra

“…Our work highlights the value of DLS in advancing our understanding of the pathogenic mechanisms underlying CVD development, while also providing a foundational framework to study other biological processes and their effects on lipoproteins, ultimately guiding the development of therapies to address these harmful processes.…”
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Eumisetoma pada Toraks dan Abdomen: Suatu Kasus Jarang by Jimy Fran, Istiana Fiatiningsih, Ilhami Romus

“…Supporting investigations such as direct microscopy, histopathology with biopsy, and culture are needed to establish the diagnosis. The therapies are antifungal drugs and surgery. Death is possible if the infection occurs in the chest or head cavity. …”
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Therapeutic resources used by physiotherapists for the relief of labor pain: a cross-sectional study by Alessandra de Campos Gonçalves, Giovana Garçoni Poli, Clara Maria de Araujo Silva, Ana Carolina Sartorato Beleza, Richard Eloin Liebano

“…Participants chose to utilize non-pharmacological therapies and resources that are within the scope of physiotherapists’ practice for labor pain. …”
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pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy by Noeen Sarfraz, David Okuampa, Hannah Hansen, Mark Alvarez, Elyse M. Cornett, Juyeon Kakazu, Adam M. Kaye, Alan D. Kaye

“…Current pharmacologic therapies include Modafinil and Armodafinil for EDS and sodium oxybate for cataplexy. …”
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Breaking boundaries: role of the brain barriers in metastatic process by Nasim Izadi, Peter Solár, Klaudia Hašanová, Alemeh Zamani, Maryam Shahidian Akbar, Klára Mrázová, Martin Bartošík, Tomáš Kazda, Roman Hrstka, Marek Joukal

“…Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. …”
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