Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering by Maryam Tamaddon, Sorousheh Samizadeh, Ling Wang, Gordon Blunn, Chaozong Liu

“…Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. …”
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CITMIC: Comprehensive Estimation of Cell Infiltration in Tumor Microenvironment based on Individualized Intercellular Crosstalk by Xilong Zhao, Jiashuo Wu, Jiyin Lai, Bingyue Pan, Miao Ji, Xiangmei Li, Yalan He, Junwei Han

“…A comprehensive characterization of cell and intercellular crosstalk in the TME is essential for understanding tumor biology and developing effective therapies. However, current cell infiltration analysis methods only partially describe the TME's cellular landscape and overlook cell‐cell crosstalk. …”
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Contribution of Gut Microbiota to Immune Tolerance in Infants by Constanza S. Méndez, Susan M. Bueno, Alexis M. Kalergis

“…These observations have led to the study and development of therapies oriented to modifying the microbiota and metabolite profiles, such as the use of pre- and probiotics and the determination of their capacity to induce tolerance to allergens that are relevant to FA. …”
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N-acetylglutamate synthetase deficiency - literature review by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Natalia Szymkowiak, Ewa Gardocka

“…Summary:  Expanding research aims to explore novel treatments in NAGSD, dietary strategies, and the safety of current therapies during pregnancy. …”
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Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations by Pratibha Pandey, Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Seungjoon Moon, Shivam Pandey, Suhas Ballal, Sanjay Kumar, Fahad Khan, Bonglee Kim

“…Therefore, our review aimed to update the multifaceted benefits of bergenin to the future scientists and researchers, which can be leveraged to formulate safer and novel cancer therapies, while also establishing a robust framework for future investigations into bergenin in cancer treatment. …”
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Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis by Xiangyang Xia, Quanwei Tao, Qunchao Ma, Huiqiang Chen, Jian’an Wang, Hong Yu

“…The analyses provide new insights into molecular pathways of MSCs-based therapies and their augmentation by GHRH analogues.…”
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Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri: intraspecific and interspecific patterns by Chunxiu Lin, Yuxing Zheng, Bo Zhang, Guopeng Lin, Kexin Shang, Jianxin Zhao, Gang Wang, Wei Chen

“…Taken together, the results of this study could assist researchers in developing effective therapies for IBD.…”
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The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow by Sirikul Manochantr, Kulisara Marupanthorn, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Prakasit Sanguanjit

“…Moreover, the information of miRNA expression and function during osteogenic differentiation may be useful for the development of new therapeutics or enhanced an in vitro culture technique required for stem cell-based therapies in the bone regeneration.…”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

“…Abstract OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. Here, we investigate the therapeutic potential of the brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX and GEM SHH-MB models. …”
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Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve by Beth Smith, Tonia A Douglas, Alexandra L Quittner, Anna M Georgiopoulos, Maggie Harrigan

“…The advent of CF transmembrane conductance regulator modulator therapies is transforming the psychosocial landscape for PWCF with new challenges and evolving psychosocial needs. …”
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Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics by Kouji Banno, Iori Kisu, Megumi Yanokura, Kenta Masuda, Yusuke Kobayashi, Arisa Ueki, Kosuke Tsuji, Wataru Yamagami, Hiroyuki Nomura, Nobuyuki Susumu, Daisuke Aoki

“…Further understanding of these issues may permit development of new therapies.…”
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Infertility in Men with Spinal Cord Injury: Research and Treatment by Nancy L. Brackett

“…Erectile dysfunction may be treated by the same therapies that are used in the general population. …”
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HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes by Irma Colombo, Enrico Sangiovanni, Roberta Maggio, Carlo Mattozzi, Stefania Zava, Yolanda Corbett, Marco Fumagalli, Claudia Carlino, Paola Antonia Corsetto, Diletta Scaccabarozzi, Stefano Calvieri, Angela Gismondi, Donatella Taramelli, Mario Dell’Agli

“…Moreover, HaCaT cells maintained in low Ca2+ medium and 80% confluent are similar to normal keratinocytes in terms of cytokine production suggesting that HaCaT cells may be a useful model to investigate anti-inflammatory interventions/therapies on skin diseases.…”
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A Unique Case of Metformin-Associated Lactic Acidosis by Benjamin Gershkovich, Christopher McCudden, Kevin D. Burns

“…The patient responded well to supportive therapies and achieved full renal recovery one week after admission. …”
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Retrospective Analysis of Rechallenge with Ipilimumab in Patients with Metastatic Melanoma by A. A. Formozo, J. R. Gomes, R. A. Schmerling, A. C. Buzaid

“…Despite the current alternatives for salvage therapies, rechallenging with ipilimumab might be an alternative to be considered in patients who had initial benefit.…”
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Adipose-Derived Mesenchymal Stromal/Stem Cells: Tissue Localization, Characterization, and Heterogeneity by Patrick C. Baer, Helmut Geiger

“…It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal stromal/stem cells (ASCs) yields a high amount of stem cells, which is essential for stem-cell-based therapies and tissue engineering. Several studies have provided evidence that ASCs in situ reside in a perivascular niche, whereas the exact localization of ASCs in native adipose tissue is still under debate. …”
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Intracranial artery dolichoectasia: What should the neurologist know? by Lorena Dellagnesi Depieri, Renan Rodrigues Neves Ribeiro do Nascimento, Lorena Souza Viana

“…Finally, we highlight the unmet clinical needs related to IADE management, which may involve pharmacological and surgical therapies tailored to individual cases, with careful consideration of safety and efficacy.…”
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Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat by Leticia Cruz-Antonio, María Elena Sánchez-Mendoza, Jazmín García-Machorro, Yaraset López-Lorenzo, Jesús Arrieta

“…One preventative strategy involves the use of omeprazole; however, its chronic use is associated with adverse effects, highlighting the need for alternative therapies. This study evaluated the protective effects of methyl eugenol (ME) on gastric mucosal damage in a rat model of SCI. …”
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Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Our findings indicate that ADSCs exert therapeutic effects in a paracrine manner through their secretome, which can be a viable alternative to cell-based regenerative therapies.…”
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T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives by Alessia Alunno, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Giulia Mirabelli, Francesca Cannarile, Paola Cipriani, Roberto Giacomelli, Roberto Gerli

“…In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. …”
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