Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2 by Joshua P. Klopper, Vibha Sharma, Reid Bissonnette, Bryan R. Haugen

“…These studies provide insight into potential mechanisms of tumor response or resistance to these novel therapies.…”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…Immunotherapy with checkpoint inhibitors produced significant clinical responses in a subset of cancer patients who were resistant to prior therapies. However, Castration-resistant prostate cancer (CRPC) is seriously lack of T cell infiltration, which greatly limits the clinical application of immunotherapy, but the mechanism is unclear. …”
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cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…This pathway’s dual role in gynecological cancers, either promoting antitumor immunity or facilitating tumor immune evasion, makes it a compelling target for innovative therapies. The article outlines cGAS/STING’s influence on tumor microenvironments, immune surveillance, and inflammation, with emphasis on molecular mechanisms driving cancer progression. …”
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Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

“…Besides, combination therapies are recommended.…”
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Applications of Neuroimaging to Disease-Modification Trials in Alzheimer’s Disease by Adam S. Fleisher, Michael Donohue, Kewei Chen, James B. Brewer, Paul S. Aisen, the Alzheimer’s Disease Neuroimaging Initiative

“…Critical to development of new therapies for Alzheimer’s disease (AD) is the ability to detect clinical or pathological change over time. …”
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In Vitro Effects of Strontium on Proliferation and Osteoinduction of Human Preadipocytes by V. Nardone, R. Zonefrati, C. Mavilia, C. Romagnoli, S. Ciuffi, S. Fabbri, G. Palmini, G. Galli, A. Tanini, M. L. Brandi

“…These findings indicate a role for Sr2+ in supporting bone regeneration during the process of skeletal repair in general, and, more specifically, when cell therapies are applied.…”
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Long Noncoding RNA uc001pwg.1 Is Downregulated in Neointima in Arteriovenous Fistulas and Mediates the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Lei Lv, Haozhe Qi, Xiangjiang Guo, Qihong Ni, Zezhen Yan, Lan Zhang

“…This study represents the first effort of identifying a novel candidate lncRNA for modulating the function of iPSC-ECs, which may facilitate the improvement of stem cell-based therapies for AVF failure.…”
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The Role of Complement System in Septic Shock by Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang

“…A better understanding of the underlying mechanisms is important to develop effective therapies. Basic and clinical studies suggest that activation of complements in the common cascade, for example, complement component 3 (C3) and C5, is involved in the development of septic shock. …”
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Efficacy of Adjunctive Treatments Added to Olanzapine or Clozapine for Weight Control in Patients with Schizophrenia: A Systematic Review and Meta-Analysis by Yun-Jung Choi

“…Adverse effects regarding adjunctive therapies were tolerable and showed statistically no significances compared to control groups. …”
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Adult Hip Flexion Contracture due to Neurological Disease: A New Treatment Protocol—Surgical Treatment of Neurological Hip Flexion Contracture by Alberto Nicodemo, Chiara Arrigoni, Andrea Bersano, Alessandro Massè

“…In this study we report our experience on surgical treatment of adult hip flexion contracture due to neurological diseases; we have tried to outline an algorithm to choose the best treatment avoiding useless or too aggressive therapies. We present 5 cases of adult hips flexion due to neurological conditions treated following our algorithm. …”
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Longitudinal genomic profiling using liquid biopsies in metastatic nonsquamous NSCLC following first line immunotherapy by Haolun Ding, Min Yuan, Yaning Yang, Xu Steven Xu

“…Overall, longitudinal liquid biopsy profiling provided valuable insights into lung cancer biology post-immunotherapy, potentially guiding personalized therapies and future drug development.…”
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Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions by Deepthi Venkatachalapathy, Parveen Doddamani, Aradya V Hirriyannaiah, Prashant Vishwanath, Suma Nataraj, Akila Prashant

“…Developing more potent and precise cancer therapies hinges on our ability to identify and understand these cancer-initiating cells within solid tumors. …”
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Integrated cancer cell-specific single-cell RNA-seq datasets of immune checkpoint blockade-treated patients by Mahnoor N. Gondal, Marcin Cieslik, Arul M. Chinnaiyan

“…Abstract Immune checkpoint blockade (ICB) therapies have emerged as a promising avenue for the treatment of various cancers. …”
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Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice by S. O. Maslennikova, G. V. Kontsevaya, M. A. Zolotykh, M. V. Anisimova, N. A. Feofanova, M. P. Moshkin, S. A. Nedospasov, L. A. Gerlinskaya

“…Although ant-cytokine therapies have been used in millions of patients, the consequences of cytokine deficiency for reproductive functions are poorly understood and need attention. …”
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Progress and application of intelligent nanomedicine in urinary system tumors by Yingming Xiao, Lei Zhong, Jinpeng Liu, Li Chen, Yi Wu, Ge Li

“…Finally, we have assessed the potential of intelligent nanomedicine in the management of urinary system tumors, emphasizing emerging trends such as personalized nanomedicine and combination therapies. This comprehensive review underscores the substantial contributions of nanomedicine to the field of oncology and offers a promising outlook for more effective and precise treatment strategies for urinary system tumors.…”
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The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock by Gennaro De Pascale, Salvatore Lucio Cutuli, Mariano Alberto Pennisi, Massimo Antonelli

“…Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice.…”
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PPARγ Expression and Function in Mycobacterial Infection: Roles in Lipid Metabolism, Immunity, and Bacterial Killing by Patricia E. Almeida, Alan Brito Carneiro, Adriana R. Silva, Patricia T. Bozza

“…Collectively, PPARγ is emerging as a regulator of tuberculosis pathogenesis and an attractive target for the development of adjunctive tuberculosis therapies.…”
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Efficient Predictor for Immunotherapy Efficacy: Detecting Pan‐Clones Effector Tumor Antigen‐Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens by Weibiao Zeng, Jin Wang, Zhike Chen, Jian Yang, Ao Zhu, Yan Zheng, Xianlan Chen, Yuhan Liu, Leilei Wu, Yufeng Xie, Sheng Ju, Jun Chen, Cheng Ding, Chang Li, Xin Tong, Mi Liu, Jun Zhao

“…This method can also be applied to evaluate the efficacy of other treatments, such as radiotherapy, oncolytic viruses, and nanomedicine‐based therapies.…”
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Evaluation of the Effects of Charged Amino Acids on Uncontrolled Seizures by Hossein Ali Ebrahimi, Saeed Ebrahimi

“…The present study investigated patients who did not respond to common and, even in some cases, adjuvant therapies, with two seizures or more per week, regardless of the type of the inflicted epilepsy. …”
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Brain White Matter Impairment in Patients with Spinal Cord Injury by Weimin Zheng, Qian Chen, Xin Chen, Lu Wan, Wen Qin, Zhigang Qi, Nan Chen, Kuncheng Li

“…The affection of left AG on rehabilitation therapies need to be further researched in the future.…”
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