Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats by Maria J. Crespo, Marie Roman, Jonathan Matias, Myrna Morales, Hector Torres, Jose Quidgley

“…The addition of the ryanodine receptor (RyR) blocker dantrolene to standard therapies reduces vasospasms in nondiabetics. Whether diabetics with CVSP also benefit from this drug, however, is unknown. …”
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Myocardial Bridging, Unusual Cause of Myocardial Infarction; Case Report and Review of Literature by Merga Daba, Dawit Bineyam, Ibraist Yohannes, Beniam Yohannes, Rabirra Waktola, Eshetu Bedada

“…High resolution CT angiography is the gold standard for diagnostic evaluation, with the length and depth of the bridge, and response to conservative therapies guiding clinical decision making on surgical correction. …”
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Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells by Li-Xian Yang, Chuangye Qi, Si Lu, Xiang-Shi Ye, Parnaz Merikhian, Du-Yu Zhang, Tao Yao, Jiang-Sha Zhao, Ying Wu, Yongshi Jia, Bo Shan, Jinghai Chen, Xiaozhou Mou, Jia You, Wenbo Li, Yu-Xiong Feng

“…Abstract Liver fibrosis is a critical liver disease that can progress to more severe manifestations, such as cirrhosis, yet no effective targeted therapies are available. Here, we identify that ATF4, a master transcription factor in ER stress response, promotes liver fibrosis by facilitating a stress response-independent epigenetic program in hepatic stellate cells (HSCs). …”
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Induction of Expression of CD271 and CD34 in Mesenchymal Stromal Cells Cultured as Spheroids by Bruno Corrêa Bellagamba, Patrícia Bencke Grudzinski, Pedro Bins Ely, Paulo de Jesus Hartmann Nader, Nance Beyer Nardi, Lindolfo da Silva Meirelles

“…Cultured mesenchymal stromal cells (MSCs) are cells that can be used for tissue engineering or cell therapies owing to their multipotency and ability to secrete immunomodulatory and trophic molecules. …”
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Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury by Akira Ikumi, Yuki Hara, Eriko Okano, Sho Kohyama, Norihito Arai, Yu Taniguchi, Hisashi Sugaya, Tomokazu Yoshioka, Akihiro Kanamori, Masashi Yamazaki

“…In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. …”
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Systematic Review of Electroacupuncture for Bell’s Palsy by Min-seok Go, Seong-hyun Lee, Ji-eun Oh, Seung-chul Yeom, Tae-ha Kwon, Sae-young Bong, Cha-young Lee, Hye-jin Shin

“…Among the randomized controlled trials (RCTs) targeting patients with Bell’s palsy, studies comparing EA treatment with other therapies in PubMed, OVID, Cochrane RCTs, and China National Knowledge Infrastructure were searched up to April 2024. …”

The Physiology, Pharmacology and Therapeutic Manipulation of the Internal Anal Sphincter by Oliver M Jones, Alison F Brading, Neil J McC Mortensen

“…However, clinical trials have yet to establish the optimum doses, dose intervals and routes of administration for many of these therapies. Furthermore, it is uncertain whether this medical approach should be applied to all patients or just to an as yet undefined subgroup. …”
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Lawsonia intracellularis T3SS effector LI0758, an Rce1 ortholog, activates MAPK and NF-κB signaling in mammalian cells by Yuanxiu Zhong, Yiyun Duan, Fenju Lai, Jinhua Zhang, Yimin Dai

“…Further investigation holds promise for elucidating novel bacteria-host interaction mechanisms and fostering the development of innovative therapies against proliferative enteritis.…”
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Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored by Fernando González, René López, Elizabeth Arriagada, René Carrasco, Natalia Gallardo, Eduardo Lorca

“…There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period. …”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Therefore, strategies for activating the Tie2 signaling pathway have been developed as potential therapies for neurovascular diseases. Here, we developed a human Tie2-agonistic antibody (MT-100) that not only resists Ang-2 antagonism and activates Tie2 signaling but also regulates a novel target, sushi repeat-containing protein X-linked 2 (Srpx2). …”
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Studying Cortical Plasticity in Ophthalmic and Neurological Disorders: From Stimulus-Driven to Cortical Circuitry Modeling Approaches by Joana Carvalho, Remco J. Renken, Frans W. Cornelissen

“…This question on neuroplasticity is particularly relevant in the context of rehabilitation therapies that attempt to overcome limitations or damage, through either perceptual training or retinal and cortical implants. …”
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Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection by Karolína Štaflová, Aleš Zábranský, Iva Pichová

“…To better understand the factors involved in viral infection and pathogenesis and to develop novel therapies, it is crucial to investigate virus–host interactions. …”
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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

“…Deploying mFISHseq as a research-use only test on 48 patients demonstrates clinical feasibility, revealing insights into the efficacy of targeted therapies, like CDK4/6 inhibitors, immunotherapies, and ADCs.…”
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An elderly patient with low-grade fibromyxoid sarcoma with early postoperative recurrences and metastases: a case report by Amr Mansour, Assil Mahamid, Eyal Behrbalk

“…Surgery remains the cornerstone of treatment, but ongoing research into systemic therapies may offer new options for managing metastatic or recurrent low-grade fibromyxoid sarcoma in the future.…”
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Malnutrition-Sarcopenia Syndrome: Is This the Future of Nutrition Screening and Assessment for Older Adults? by Maurits F. J. Vandewoude, Carolyn J. Alish, Abby C. Sauer, Refaat A. Hegazi

“…By examining aspects of both conditions, clinicians can more fully assess their patients’ clinical and nutritional status and can tailor targeted therapies to meet their needs and improve outcomes. …”
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A Novel Real-Time Threshold Algorithm for Closed-Loop Epilepsy Detection and Stimulation System by Liang-Hung Wang, Zhen-Nan Zhang, Chao-Xin Xie, Hao Jiang, Tao Yang, Qi-Peng Ran, Ming-Hui Fan, I-Chun Kuo, Zne-Jung Lee, Jian-Bo Chen, Tsung-Yi Chen, Shih-Lun Chen, Patricia Angela R. Abu

“…At present, the main treatment methods are drug, surgical, and electrical stimulation therapies. Electrical stimulation has recently emerged as an alternative treatment for reducing symptomatic seizures. …”
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The Challenges of Living with Inflammatory Bowel Disease: Summary of a Summit on Patient and Healthcare Provider Perspectives by Judith Bray, Aida Fernandes, Geoffrey C. Nguyen, Anthony R. Otley, Joan Heatherington, Jennifer Stretton, Natasha Bollegala, Eric I. Benchimol

“…There is currently no cure for IBD, although earlier diagnosis and new therapies have improved the overall health outcomes and quality of life for patients. …”
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Secukinumab-Induced Inflammatory Bowel Disease in a Patient Treated for Chronic Plaque Psoriasis and Psoriatic Arthritis: A Case Report and Review of the Role of Novel Biologic Age... by K. M. Darch, T. L. Holland, L. J. Spelman

“…The availability of a range of novel, targeted therapies for their treatment, most notably the availability of biologic agents, has revolutionised management of these conditions and allowed for significant improvements in patient outcomes. …”
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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases by Xinyu Yang, Xiangyu Gao, Xiaofan Jiang, Kangyi Yue, Peng Luo

“…This review offers new insights for developing highly targeted therapies in this field.…”
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Beyond the icebox: modern strategies in organ preservation for transplantation by Kidus Haile Yemaneberhan, Minseok Kang, Jun Hwan Jang, Jin Hee Kim, Kyeong Sik Kim, Ho Bum Park, Dongho Choi

“…Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the progress of organ preservation, focusing on the shift from static cold storage (SCS) to advanced machine perfusion techniques such as hypothermic (HMP) and normothermic machine perfusion (NMP). …”
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