The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases.…”
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Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer by Agnieszka Chytła, Stephanie Rattay, Baki Akgül, Martin Sztacho

“…Understanding the PI(4,5)P2-related mechanisms underlying metastasis may provide insights into potential therapeutic targets, paving the way for more effective therapies and improved patient outcomes.…”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Understanding the dynamic interactions of glial cells with neurons provides promising avenues for novel epilepsy therapies. Targeting these cells may lead to improved seizure control and better clinical outcomes, offering hope for patients with refractory epilepsy.…”
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Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread. by Alexander Tishchenko, Nicolás Romero, Cliff Van Waesberghe, Jonas L Delva, Oliver Vickman, Gregory A Smith, Thomas C Mettenleiter, Walter Fuchs, Barbara G Klupp, Herman W Favoreel

“…The current study identifies key viral and cellular proteins involved in alphaherpesvirus-mediated suppression of GJIC and reveals that GJIC inhibition enhances virus intercellular spread, thereby opening new avenues for the design of targeted antiviral therapies.…”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Very recent phase III trials with the leading agent, a humanised anti-CD3 antibody, call into question whether further development of these biologics represents a step forward or more of the same. Combination therapies of one or more of these humanised antibodies are also being considered, and they face identical, if not more serious, impediments and safety issues. …”
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BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling by Chengzhu Zhao, Yoshiko Inada, Souta Motoike, Daisuke Kamiya, Kyosuke Hino, Makoto Ikeya

“…This study provides novel insights into the development of future FOP therapies.…”
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Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. This paper examines and discusses phage nanomedicine applications and the immunomodulatory effects of bacteriophage exposure and treatment modalities.…”
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A scATAC-seq atlas of stasis zone in rat skin burn injury wound process by Ruikang Li, Jiashan Li, Shuai Liu, Xinya Guo, Jianyu Lu, Tao Wang, Tao Wang, Junjie Chen, Yue Zheng, Yue Yuan, Jiaxin Du, Jiaxin Du, Bolin Zhu, Bolin Zhu, Xiaoyu Wei, Pengcheng Guo, Longqi Liu, Longqi Liu, Xun Xu, Xi Dai, Runzhi Huang, Xin Liu, Xin Liu, Xiaoyan Hu, Shiwei Wang, Shizhao Ji

“…This comprehensive cellular and molecular atlas of the stasis zone provides a powerful resource for developing targeted therapies aimed at improving burn injury recovery and minimizing long-term consequences.…”
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Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer by A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li

“…These findings suggest that the Arp2/3 complex-associated genes can serve as potential biomarkers for predicting the malignant transformation of pancreatic cysts, opening new avenues for targeted therapies and early detection strategies.…”
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Resveratrol, Piceatannol, Curcumin, and Quercetin as Therapeutic Targets in Gastric Cancer—Mechanisms and Clinical Implications for Natural Products by Paulina Warias, Paulina Plewa, Agata Poniewierska-Baran

“…Quercetin, a flavonoid found in various fruits and vegetables, induces cell cycle arrest and apoptosis while enhancing the efficacy of conventional therapies. Despite their potential, challenges such as low bioavailability limit their clinical application, necessitating further research into novel delivery systems. …”
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Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species by Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez

“…The limitations of current therapies and the emergence of drug-resistant parasites underscore the need for new treatments that could harness the host immune response. …”
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Exploring the Role of Tranexamic Acid in Dermatology: A literature Review by Aleksandra Górska, Natalia Gniaź, Wiktor Grela, Jagoda Niewiadomska, Daria Furtak, Dawid Tulej, Natalia Marko, Alicja Dziedzic, Dominika Marciniuk, Paulina Głogowska

“…Purpose This review aims to identify and summarize the current applications of tranexamic acid in dermatology, including its mechanisms of action, effectiveness, and safety in treating common conditions such as melasma, hyperpigmentation, rosacea, psoriasis, angioedema, and in scar and discoloration therapies. State of Knowledge An analysis of the existing literature highlights the growing interest in TXA’s dermatological applications. …”
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Emerging Perspectives in Scaffold for Tissue Engineering in Oral Surgery by Gabriele Ceccarelli, Rossella Presta, Laura Benedetti, Maria Gabriella Cusella De Angelis, Saturnino Marco Lupi, Ruggero Rodriguez y Baena

“…Advances in tissue engineering have resulted in the development of innovative scaffold designs, complemented by the progress made in cell-based therapies. In vitro bone regeneration can be achieved by the combination of stem cells, scaffolds, and bioactive factors. …”
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Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance by Fabrizia d'Apuzzo, Salvatore Cappabianca, Domenico Ciavarella, Angela Monsurrò, Armando Silvestrini-Biavati, Letizia Perillo

“…The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences. …”
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Alpha-Fetoprotein and Novel Tumor Biomarkers as Predictors of Hepatocellular Carcinoma Recurrence after Surgery: A Brilliant Star Raises Again by Quirino Lai, Fabio Melandro, Rafael S. Pinheiro, Andrea Donfrancesco, Bashir A. Fadel, Giovanni B. Levi Sandri, Massimo Rossi, Pasquale B. Berloco, Fabrizio M. Frattaroli

“…All these markers have been largely used as predictors in patients treated with hepatic resection or locoregional therapies, mainly in Eastern countries. In recent studies, AFP has been proposed as predictor of recurrence after liver transplantation and as selector of patients in the waiting list. …”
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AI allows pre-screening of FGFR3 mutational status using routine histology slides of muscle-invasive bladder cancer by Pierre-Antoine Bannier, Charlie Saillard, Philipp Mann, Maxime Touzot, Charles Maussion, Christian Matek, Niklas Klümper, Johannes Breyer, Ralph Wirtz, Danijel Sikic, Bernd Schmitz-Dräger, Bernd Wullich, Arndt Hartmann, Sebastian Försch, Markus Eckstein

“…In this work, we demonstrate that our model achieves high sensitivity (>93%) on advanced and metastatic cases while reducing molecular testing by 40% on average, thereby offering a cost-effective and rapid pre-screening tool for identifying patients eligible for FGFR3 targeted therapies.…”
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The influence of the sinonasal microbiome on the development and management of rhinosinusitis by Miriam Lang, Dawid Bereza, Maria Kulak-Waśniewska, Igor Moreau, Paulina Polańska, Katarzyna Sokołowska, Barbara Woch

“…A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals. …”
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Immunologists' Perspectives on Monogenic Inflammatory Bowel Diseases by Maryiam Jama Ali Osman, Emine Selva Aydoğdu, Rafah Mackeh, Ahmet Özen, Bernice Lo

“…In recent times, novel therapies have emerged, targeting specific causative genes or affected pathways. …”
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Combined therapeutic option for NDM-producing Serratia Marcescens – an in vitro study from clinical samples by Balbina Chilombo Albano, Leticia Ramos Dantas, Gabriel Burato Ortis, Paula Hansen Suss, Felipe Francisco Tuon

“…Background: Treating NDM-producing bacteria poses a significant challenge, especially for those bacteria inherently resistant to polymyxin, such as Serratia marcescens, necessitating combined therapies. Objective: To assess in vitro the synergistic effect of different antimicrobial combinations against NDM-producing S. marcescens. …”
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Patient-derived xenografts from circulating cancer stem cells as a preclinical model for personalized pancreatic cancer research by Benedikt J. Wagner, Andreas Ettner-Sitter, Nicolas A. Ihlo, Merle Behr, Sebastian Koelbl, Stefan M. Brunner, Florian Weber, Bettina M. Rau, Hans J. Schlitt, Christoph Brochhausen, Rebecca Schoenmehl, Annalena Artinger, Dorothea Schott, Monika Pizon, Katharina Pachmann, Thiha Aung, Silke Haerteis, Christina Hackl

“…Hence, this model represents a novel and fast option for individualized testing of new therapies for PDAC.…”
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