Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis by Weiqian Chen, Qin Wang, Yini Ke, Jin Lin

“…We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.…”
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Beyond Immunuhistochemistry: Molecular Insights Into Round Cell Soft Tissue Tumors by Prashanth Kumar Madoori, Sujatha Tejavat

“…The advent of techniques such as fluorescence in situ hybridization (FISH), reverse transcriptase-polymerase chain reaction (RT-PCR), and next-generation sequencing (NGS) has enabled detection of genetic fusions and aberrations critical for tumor identification and targeted therapies. Integration of molecular pathology with traditional diagnostic approaches is essential for improving diagnostic accuracy, prognostication, and therapeutic strategies, paving the way for personalized medicine in the management of RCSTTs. …”
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Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture by Silvia Cantoni, Francesca Bianchi, Margherita Galletti, Elena Olivi, Francesco Alviano, Nazzareno Galiè, Carlo Ventura

“…Our findings could be helpful to develop innovative cell-based therapies for future clinical applications with distinct therapeutic purposes.…”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Despite an increasing number of available therapies, the treatment of neuropathic pain remains a major issue. …”
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Contribution of long-lived plasma cells to antibody-mediated allograft rejection by Eunkyeong Jang, Jeehee Youn

“…Notably, they are refractory to traditional immunosuppressants and B cell depletion therapies. This resistance, coupled with their longevity, may explain why current treatments targeting antibody-mediated rejection are often ineffective. …”
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The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications by Chi-Yuan Chen, Kuo-Yen Huang, Chin-Chuan Chen, Ya-Hsuan Chang, Hsin-Jung Li, Tong-Hong Wang, Pan-Chyr Yang

“…It underscores the importance of prevention and early detection while calling for targeted therapies to combat the detrimental effects of air pollution. …”
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The Second Canadian Symposium on Hepatitis C Virus: A Call to Action by Jason Grebely, Marc Bilodeau, Jordan J Feld, Julie Bruneau, Benedikt Fischer, Jennifer F Raven, Eve Roberts, Norma Choucha, Rob P Myers, Selena M Sagan, Joyce A Wilson, Frank Bialystok, D Lorne Tyrrell, Michael Houghton, Mel Krajden, on behalf of the National CIHR Research Training Program in Hepatitis C

“…Within the next three to 10 years, it is expected that tolerable, short-duration (12 to 24 weeks) therapies capable of curing >90% of those who undergo treatment will be approved. …”
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Rare or orphan diseases. A review study by Ener Mantilla Horna, Jóhel Osorio Fernández

“…This review analyzes the current literature on these diseases, highlighting the importance of research, early diagnosis, and the development of therapies. There are more than 6,000 rare diseases, each with different symptoms and trajectories, and a prevalence of less than 1 case per 2,000 people. …”
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Neonatal Nonketotic Hyperglycinemia: A Severe Case With Prenatal Indicators and Comprehensive Review of Recognition and Management by Samaneh Parviz, Dariush Hooshyar

“…Treatment included anticonvulsants for seizure management, sodium benzoate for glycine reduction, and NMDA receptor antagonists (ketamine and dextromethorphan) to modulate neurotoxicity. Despite these therapies, the patient demonstrated poor neurodevelopmental outcomes, with rapid progression to severe impairment. …”
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Form and Function of Sleep Spindles across the Lifespan by Brittany C. Clawson, Jaclyn Durkin, Sara J. Aton

“…Because sleep spindles are similarly affected in disorders of neurodevelopment (such as schizophrenia) and during aging (such as neurodegenerative conditions), both types of disorders may benefit from therapies based on a better understanding of spindle function.…”
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Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

“…The current evidence on the safety and efficacy of ASOs in brain diseases will help identify opportunities for a broader range of nucleic acids and accelerate the clinical translation of these innovative therapies. …”
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Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies by Dingtian Luo, Jing Zhou, Shuiliang Ruan, Binzhong Zhang, Huali Zhu, Yangming Que, Shijie Ying, Xiaowen Li, Yuanmin Hu, Zhengwei Song

“…We also discuss emerging strategies to overcome resistance, including combination therapies, novel immunotherapeutic approaches, and personalized treatment strategies based on tumor genomics and the immune microenvironment. …”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…Additionally, emerging immunotherapeutic strategies, such as immune checkpoint inhibitors, macrophage reprogramming, and antibody-based therapies, are summarized in detail, showcasing their potential to improve therapeutic outcomes.…”
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The Isosteroid Alkaloid Imperialine from Bulbs of Fritillaria cirrhosa Mitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like... by Dongdong Wang, Qingdan Du, Houcong Li, Shu Wang

“…Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. Present therapies for COPD have limited effect on reducing the progression of COPD and suppressing the inflammatory response in the lung. …”
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Medical imaging-based companion diagnostics for solid tumors by Rui Yin, Qingpeng Zhang, Shiyi Liao, Chang Lu, Cheng Zhang, Qingyun Cai, Guosheng Song

“…They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments. …”
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TNM-Like Classification: A New Proposed Method for Heart Failure Staging by Francesco Fedele, Maria Chiara Gatto, Alessandra D’Ambrosi, Massimo Mancone

“…Moreover, a classification based not only on symptomatic and syndromic typical features of heart failure, but also on functional data of each system, could allow us to apply the most appropriate therapies, to obtain a more accurate prognosis, and to employ necessary and not redundant human and financial resources. …”
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Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization by Zhewei Dong, Yingli Fu, Zhongming Cai, Hao Dai, Yucang He

“…Exosomes derived from ADSCs (ADSC-EXOs) exhibit biological functions similar to those of ADSCs but can circumvent the limitations associated with cellular injection therapies. Potent anti-inflammatory substances contained in exosomes include the glycoprotein MFGE8, the cytokines such as prostaglandin E2, IL-6, and IGF, as well as non-coding nucleotides (miR-451a, miR-23, miR-30d-5p, let-7, lncRNA DLEU2, circRps5, Circ-Ptpn4, and mmu_ circ_0001359). …”
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Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice by Carolina Panis, Vanessa Jacob Victorino, Vera Lúcia Hideko Tatakihara, Rubens Cecchini, Luiz Vicente Rizzo, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho

“…These data provide a better understanding about the influence of NO-interfering therapies for the inflammatory response toward T. cruzi infection.…”
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Targeting ferroptosis: a promising approach for treating lung carcinoma by Ziyang Wu, Yan Zhang, Wendi Zhong, Kunjian Wu, Tian Zhong, Tao Jiang

“…The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. …”
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Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed? by Jiayu Zhai, Ju Rong, Qiuxia Li, Jieruo Gu

“…This paper tries to summarize the association of several candidate genes with risk for AS in the Han ethnic Chinese population and aims to identify the novel inflammatory pathways and provide potential strategies for better therapies.…”
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