From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases by Deepika C. Parameswarappa, Ashwini Kulkarni, Niroj Kumar Sahoo, Srikanta Kumar Padhy, Sumit Randhir Singh, Elise Héon, Jay Chhablani

“…Traditional imaging methods help in structural assessments, but limitations exist in early functional cellular-level detection that are crucial for guiding new therapies. <b>Methods</b>: This review includes a systematic search of PubMed and Google Scholar for studies on advanced imaging techniques for IRDs. …”
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Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse by Chunjun Sheng, Feng Li, Ziwei Lin, Manna Zhang, Peng Yang, Le Bu, Hui Sheng, Hong Li, Shen Qu

“…Targeting these factors could optimize T2D therapies.…”
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Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia by Paschalis Evangelidis, Konstantinos Tragiannidis, Eleni Gavriilaki, Athanasios Tragiannidis

“…In the era of precision medicine, targeted and individualized therapies are crucial to achieving better outcomes for pediatric patients with ITP, especially when chronic refractory disease is developed.…”
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Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage by Xuehai Deng, Jianlin Ding, Chang Liu, Zhong Wang, Junchi Wang, Qiyue Duan, Weida Li, Xinlong Chen, Xiaoping Tang, Long Zhao

“…Further research on SAH is needed to reveal the underlying mechanisms of hydrocephalus and develop translatable therapies. A model that can stably mimic the histopathological and neuroethological features of hydrocephalus is critical for animal experiments. …”
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In vitro studies on the immunomodulatory effects of fulvic acid extract from palm oil empty fruit bunch (OPEFB) by Dimarwanita Firda, Mariya Silmi, Nur Annisa Dewi Fitria, Latisya Silva, Faramitha Yora, Goenadi Didiek Hadjar

“…With an increasing need for sustainable natural therapies, FA has shown promise in treating degenerative diseases by modulating immune responses. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Beyond these, six promising molecules currently in Phase II clinical trials are designed to target arabinan synthesis pathways, sutezolid, TBA 7371, OPC-167832, SQ109, and both benzothiazinone derivatives BTZ043 and PBTZ169, highlighting advancements in the development of cell wall-targeting therapies.…”
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Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis by Mengmeng Li, Jiangyi Wang, Qingfeng Liu, Youqing Liu, Wenyao Mi, Wei Li, Wei Li, Jingyi Li

“…Recent developments in targeted therapies and their implications for treatment selection are thoroughly discussed. …”
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The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective by Sheng Chen, Min Wang, Shuai Zhang, Xin Huang, Xinke Sui, Dou Li, Changqing Zhong, Wei Wu

“…Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. …”
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Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation by Yasutaka Tajima, Mariko Matsumura, Hiroaki Yaguchi, Yasunori Mito

“…Both cases showed neurological improvements after the immunomodulating therapies. We tried to shed some light on the understanding of immunological mechanisms of transplantation-associated HAM, focusing on therapeutic strategies based on the immunopathogenesis of the condition.…”
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Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Upregulation of vascular endothelial growth factor (VEGF), the main target of current therapies, is likely to be one of the first responses to retinal hyperglycemic stress and VEGF may represent an important survival factor in early phases of DR. …”
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Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism by Lijun Zhao, Haonan Qi, Weiting Liu, Huiying Lv, Peixian Li, Wenyue Liu, Ruili Sun, Qiongzi Wang, Xiangpeng Wang

“…PDHB and Isoacteoside could be potential avenues for targeted and combination therapies in liver cancer.…”
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Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder by Ashley Cannon, Svetlana Kurklinsky, Kimberly J. Guthrie, Douglas L. Riegert-Johnson

“…For treatment, gabapentin was ineffective and carbamazepine was not tolerated. Nontraditional therapies improved symptoms and constipation resolved with pelvic floor retraining with biofeedback. …”
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Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation by Xihang Chen, Yunfan He, Feng Lu

“…Pluripotent stem cells, with their ability to self-replicate and to give rise to any specialized cell type, are very valuable resources for cell-based medical therapies and open a number of promising avenues for studying human development and disease. …”
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In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? by Carlotta Mattioda, Claudia Voena, Gianluca Ciardelli, Clara Mattu

“…Currently available therapies, including chemotherapy, immunotherapy, and CAR-T cells, are often associated with important side effects and with the development of drug resistance and, consequently, disease relapse. …”
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Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers by Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua

“…FLT3-targeted strategies may offer new options for patients resistant to conventional therapies.…”
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Epidemiology, Prognosis, and Evolution of Management of Septic Shock in a French Intensive Care Unit: A Five Years Survey by Nicolas Boussekey, Juliette Cantrel, Lise Dorchin Debrabant, Joachim Langlois, Patick Devos, Agnes Meybeck, Arnaud Chiche, Hugues Georges, Olivier Leroy

“…Morbidity improved with time (diminution of septic shock complications, increase of the number of days alive free from mechanical ventilation and vasopressors on day 28), concomitant to an evolution of the management (earlier institution of all replacement and medical therapies and more initial volume expansion). There was no difference in mortality. …”
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Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders by I. De Toma, L. Manubens Gil, S. Ossowski, M. Dierssen

“…Here, we discuss epigenetic studies of IDDs, focusing on DS and FXS, and the use of epidrugs in combinatorial therapies for IDDs.…”
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Revolutionizing dental research in the Pacific Islands: the Pacific Islands dental research framework by Hemanth Tumkur Lakshmikantha, Ratu Osea Gavidi, Tokasa Leweni, Kantara Tiim, Kaitlyn Khan, Samantha Kumar

“…This framework expands diagnostic assessments to incorporate cultural and social determinants of oral health, combining holistic and culturally tailored therapies. By continuously integrating patient feedback, PIDRF fosters empathetic, effective support that aligns with Pacific values. …”
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The Role of Inflammation in the Pathogenesis of Preeclampsia by Michał Michalczyk, Aleksander Celewicz, Marta Celewicz, Paula Woźniakowska-Gondek, Rafał Rzepka

“…Detailed understanding of pathophysiology of inflammatory process in PE can largely contribute to new, targeted anti-inflammatory therapies that may improve perinatal outcomes in PE patients.…”
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The Problem of the Conscience Clause of Healthcare Professionals in Italy in the Years 2017-2020 by Andrzej Kobyliński

“…A living will consists in the anticipatory expression of ‘will’, by an adult or legal guardian acting in full possession of their mental faculties, concerning the possible administration or discontinuation of certain medical therapies in the future. The conscience clause, on the other hand, means the right to refuse to take such actions, which a particular person considers to be contrary to their personal convictions. …”
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