Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node by Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon

“…Advancing our understanding of lymphatic vessel involvement in regulating tumor growth and immune response may provide new therapeutic targets or treatment plans to enhance the efficacy of existing therapies. We utilized a syngeneic murine melanoma model in which we surgically disrupted the lymphatic vessel network draining from the tumor to the tumor-draining lymph node (TDLN) while leaving the TDLN intact. …”
Get full text

Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients by David H. Van Thiel, Magdalena George, Christopher M. Moore

“…The application of antifungal therapies associated with reported efficacy rates greater than 50% are those used prophylactically. …”
Get full text

Water pollution, cholera, and the role of probiotics: a comprehensive review in relation to public health in Bangladesh by Md. Rayhan Chowdhury, Ariful Islam, Valentina Yurina, Takeshi Shimosato, Takeshi Shimosato, Takeshi Shimosato

“…Probiotics are promising as an adjunctive approach to existing therapies as they can enhance gut barrier function, induce competitive exclusion of pathogens, and modulate host immune responses. …”
Get full text

Beneath the surface: unveiling the gut–brain axis in anorexia and depression by Fatima Shahid, Zain Afridi, Muhammad Ali, Muhammad Nabeel Saddique, Javed Iqbal, Anurag Jha

“…By exploring the underlying mechanisms, validating biomarkers, and developing targeted therapies, we can enhance diagnostic accuracy, improve treatment outcomes, and better support patients with AN and depression. …”
Get full text

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

“…Abstract The development of granulomas with central necrosis harboring Mycobacterium tuberculosis (Mtb) is the hallmark of human tuberculosis (TB). New anti-TB therapies need to effectively penetrate the cellular and necrotic compartments of these lesions and reach sufficient concentrations to eliminate Mtb. …”
Get full text

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications by Jiangxia Du, Minhui Shen, Jiajia Chen, Hao Yan, Zhifei Xu, Xiaochun Yang, Bo Yang, Bo Yang, Peihua Luo, Peihua Luo, Kefeng Ding, Yuhuai Hu, Qiaojun He, Qiaojun He, Qiaojun He, Qiaojun He

“…By highlighting these connections, we aim to provide insights that may contribute to the development of improved treatment strategies and targeted therapies for metabolic disorders.…”
Get full text

Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration by F. Alcayaga-Miranda, M. Varas-Godoy, M. Khoury

“…The current gain of insight in exosomes studies highlights the power of combining cell based therapies and their secreted products in therapeutic angiogenesis.…”
Get full text

Space psychology: a comprehensive approach to the future of astronaut wellbeing by Annahita Nezami

“…It highlights the importance of integrating scientific and psychological theories into digital therapies to create comprehensive evidence-based interventions. …”
Get full text

Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain by Mariana C. Souza, Tatiana A. Padua, Maria G. Henriques

“…Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium.…”
Get full text

Antibacterial evaluation of antibiotic-coated titanium and stainless steel implants in orthopaedic application: a dip-coating approach by Mesut Kariksiz, Duygu Kirkik

“…Further research is needed to optimise the coating method, explore combination therapies and evaluate the long-term efficacy of this approach in clinical settings.…”
Get full text

Selecting Candidates for Liver Transplantation: A Medical Ethics Perspective on the Microallocation of a Scarce and Rationed Resource by Eric M Yoshida

“…In particular, the contrasting viewpoints of bioethicists Nicholas Rescher and James Childress, with respect to nonmedical and social criteria in the selection of patients for scarce, life-saving therapies, are explored. Lastly, some alternative ethical models for patient selection are reviewed.…”
Get full text

Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders by En-Su Chang, Cheng-Yi Hsu, Jui-Chen Li, Rajni Dubey, Wei-Chih Kan, Ming-Jen Sheu, Chia-Hui Cheng, Chia-Yu Chang, Chin-Chia Hsu, Jiunn-Jye Chuu

“…Considering the inadequacies and adverse impacts of antibiotic therapies, a potential treatment for H. pylori infection is the need of the hour. …”
Get full text

Detoxification of Implant Surfaces Affected by Peri-Implant Disease: An Overview of Surgical Methods by Pilar Valderrama, Thomas G. Wilson Jr

“…Complete elimination of the biofilms is difficult to achieve. All therapies induce changes of the chemical and physical properties of the implant surface. …”
Get full text

Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Conclusions Understanding the molecular mechanisms underlying CCM offers potential for targeted therapies. Further research into novel mutations and treatment strategies is essential for improving patient outcomes.…”
Get full text

Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head by Weihong Zhu, Zhenmu Xu, Ding Zhou, Jiankun Xu, Yuchen He, Zhong Alan Li

“…Considering that blood supply of the femoral head plays a key role in the pathology of ONFH, angiogenic therapies have been put forward as promising treatment options. …”
Get full text

Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review by Mhd Bashir Almonajjed, Mahdi Wardeh, Abdallah Atlagh, Abdulrahman Ismaiel, Stefan-Lucian Popa, Flaviu Rusu, Dan L. Dumitrascu

“…Future research should aim to identify reliable microbiota-based biomarkers for IBS and refine microbiome-targeted therapies to enhance patient outcomes.…”
Get full text

MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury by Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu

“…Developing miRNAs are not without its challenges, but prudent design combined with existing clinical treatments will result in more effective therapies for I/R injury. This review is aimed at providing new research results obtained in this research field. …”
Get full text

Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…This review explores the molecular connections between these processes, emphasizing the potential for autophagy-targeted therapies as strategies that could be further explored in both aging and cancer treatment. …”
Get full text

Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering by Stefano Focaroli, Gabriella Teti, Viviana Salvatore, Isabella Orienti, Mirella Falconi

“…The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based therapies are combined to develop new therapeutic regimens for tissue replacement. …”
Get full text

Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy by R. Ortenberg, S. Sapoznik, D. Zippel, R. Shapira-Frommer, O. Itzhaki, A. Kubi, D. Zikich, M. J. Besser, J. Schachter, G. Markel

“…The recently approved antimelanoma therapies carry new hope for metastatic patients for the first time in decades. …”
Get full text