Glioblastoma. Past, present and future by Adriel Herrero Díaz, Luis Manuel Abreu Pereira, Ilian Esteban Tarife Romero, Diana Rosa González Tamayo

“…The improvement and creation of new anticancer therapies are the future hopes in the fight against this pathology.…”
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Mechanisms of oxidative stress-induced sperm dysfunction by Yutao Wang, Xun Fu, Hongjun Li

“…The review highlights the importance of early intervention through antioxidant therapies and lifestyle changes to mitigate the detrimental effects of oxidative stress on male fertility. …”
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Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures by Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang, Songqing Fan

“…TLSs have demonstrated positive prognostic value in NPC, making them a promising target for future therapies. This review summarizes the key characteristics of TLSs and latest research in the context of NPC. …”
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Maternal and Fetal Outcomes in Critically Ill Patients Infected with COVID‐19: A Case Series by Zenab Yusuf Tambawala, Fatima Cherifi, Wafa Mohsen, Tazeen Makhdoom, Lama Khaled Hamza

“…Results: Despite trying all available known therapies for COVID-19 at the time they presented, such as remdesivir, favipravir, steroid, hydroxychloroquine, pegylated interferon, N-acetyl cysteine, anticoagulants, prone positioning, mechanical ventilation, extracorporeal membrane oxygenation, and early delivery by cesarean, these young women in the reproductive age group could not be saved. …”
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Liver metastases in gastroenteropancreatic neuroendocrine tumours – treatment methods by Paweł Gut

“…Surgical approaches that allow the safe treatment of multiple, bilateral, large tumours, and that combine extirpative, ablative and interventional therapies, have expanded the population of patients with neuroendocrine tumors (NET) liver metastases (LMs) who can benefit from aggressive treatment of their liver disease. …”
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Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus by Danish Ahmed, Manju Sharma

“…Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+ channels (KATP) of pancreatic cells and PPAR-γ to enhance the insulin secretion and potential for GLUT expression, respectively. …”
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Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7) by Pi‐Wan Cheng, Vishwanath‐Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R. Samuelson

“…These results provide a mechanistic insight into the cause of the toxic effects of alcohol and might contribute to the development of therapies to alleviate its toxicity.…”
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PTCH1 mutations' role in keratocystic odontogenic tumors and nevoid basal cell carcinoma syndrome by Archana Behera, Mukesh Kumar Dharmalingam Jothinathan

“…This underscores the importance of targeted therapies, specifically in instances of resistance, and the tailoring of treatment plans under genetic knowledge.…”
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Inflammatory Signalling Associated with Brain Dead Organ Donation: From Brain Injury to Brain Stem Death and Posttransplant Ischaemia Reperfusion Injury by Ryan P. Watts, Ogilvie Thom, John F. Fraser

“…This has seen the development of novel therapies that directly target the inflammatory cascade.…”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy, with its significant heterogeneity complicating the identification of the most aggressive subtypes and the development of targeted therapies. In this study, we performed transcriptomic analysis of HB samples from the GEO database and identified three distinct molecular subtypes with varying prognostic outcomes. …”
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Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications by Giovanna Fusco, Rubina Paradiso, Lorena Cardillo, Maria Antonia Salvia, Saveria Dodaro, Veronica Del Monaco, Gianfranco Scarpelli, Francesca Greco, Antonio Rinaldi, Lorella Barca, Stefania Ambrogio, Antonio Limone, Esterina De Carlo, Giorgia Borriello

“…Altogether, our findings highlight the importance of investigating S. suis in cases of neonatal meningitis, as well as the necessity of assessing the antimicrobial profile to obtain useful information for developing targeted therapies.…”
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Sex hormones and immune regulation in ovarian cancer by Rui Zhao, Wenqin Lian, Qiong Xu

“…The review also discusses the therapeutic implications of these interactions, including the potential for combining hormone-based therapies with immune checkpoint inhibitors. Personalized medicine approaches, leveraging biomarkers for predicting treatment response, are considered essential for optimizing patient outcomes. …”
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Pediatric Psoriasis: A Comprehensive Review with a Focus on the Latest Therapeutic Updates by Vineet Relhan, Aneet Kaur, B. V. Priyadharshini

“…In recent past, many new topical and systemic therapies have been approved for the treatment of pediatric psoriasis. …”
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SNP Analysis of the SOD1 gene involved in Amyotrophic Lateral Sclerosis (ALS) by Hetal Patel, Anandita Banerjee, Pritha Saha, Subramaniyan Divya, Palaniyandi Ravanan, Priti Talwar

“…This comprehensive study improves our understanding of the effects of SOD1 SNPs in ALS, thereby aiding in targeted therapies development.…”
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Flexible analytic wavelet transform in a EEG based brain computer Interface Paradigm: a study in end users with mo-tor disabilities by Oana-Diana Hrisca-Eva

“…Motor imagery electroencephalogram based brain computer interface systems can help people with disabilities to communicate with an external device and to realize rehabilitation therapies. The paper proposes flexible analytic wavelet transform (FAWT) as feature extraction method. …”
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Cellular rejuvenation protects neurons from inflammation-mediated cell death by Sienna S. Drake, Abdulshakour Mohammadnia, Aliyah Zaman, Christine Gianfelice, Kali Heale, Adam M.R. Groh, Elizabeth M.-L. Hua, Matthew A. Hintermayer, Yuancheng Ryan Lu, David Gosselin, Stephanie Zandee, Alexandre Prat, Jo Anne Stratton, David A. Sinclair, Alyson E. Fournier

“…Collectively, these data reveal an aging-like phenotype in neurons under pathological neuroinflammation and support the possibility that rejuvenation therapies or senotherapeutic agents could offer a direct avenue for neuroprotection in neuroimmune disorders.…”
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Promising Response with PI3K Inhibitor for a Patient with Heavily Pretreated PIK3CA Mutation Head-and-Neck Cancer by Ming-Jing Lee, Hsiang-Fong Kao

“…To develop new agents for managing such pretreated malignancies, therapies targeting carcinogenic pathways could be possible in HNSCC patients. …”
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The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review by Ambra Di Piazza, Federica Vernuccio, Massimo Costanzo, Laura Scopelliti, Dario Picone, Federico Midiri, Francesco Salvaggi, Francesco Cupido, Massimo Galia, Sergio Salerno, Antonio Lo Casto, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla

“…Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. Dysphagia is one of the most important symptom, and it is caused by failure of the swallowing function and may lead to aspiration pneumonia, malnutrition, dehydration, weight loss, and airway obstruction. …”
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Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application by Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford, Elizabeth Gail Canty-Laird

“…Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. …”
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Micro-channels array device fabricated via two photon lithography for cell migration studies in Neuroblastoma metastatic disseminationAll original data are available at: . by Sara Micheli, Caterina Piunti, Elisa Varaschin, Marianna Peditto, Maria Luz Suarez, Marco Sorgato, Elisa Cimetta

“…Such microdevices hold great promise for advancing our understanding of metastasis and aiding the development of targeted anti-cancer therapies.…”
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