Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention by Tianxin Yang, Sunhapas Soodvilai

“…A better understanding of the molecular mechanism of TZD-induced fluid retention is essential for the development of novel therapies with improved safety profiles. An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone. …”
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Cyclosporine Regimens in Plaque Psoriasis: An Overview with Special Emphasis on Dose, Duration, and Old and New Treatment Approaches by M. D. Colombo, N. Cassano, G. Bellia, G. A. Vena

“…This paper will review the data on CsA regimens for plaque-type psoriasis and will focus the attention on dose, treatment duration, novel schedules, and role in combination therapies, including the association with biologicals.…”
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miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery by Vojtech Sprincl, Vojtech Sprincl, Nataliya Romanyuk

“…Furthermore, we discuss the challenges associated with the clinical translation of MSC-derived EV therapies and the possibilities of further enhancing EVs’ innate protective qualities. …”
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Macrophage Polarization in the Osteoarthritis Pathogenesis and Treatment by Xiongfei Zou, Hongjun Xu, Wenwei Qian

“…Additionally, this review discusses potential therapies targeting macrophage polarization, encompassing compounds, proteins, cells, and microRNAs, to offer insights into novel treatment strategies for OA.…”
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Treatment options of human demodicosis by Olga Pawełczyk

“…In contrast, a combination therapies, in which oral and local applied  medication are taken together or several types of local medication are combined have the best effect. …”
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New Targets of Neuroprotection in Ischemic Stroke by Marco Bacigaluppi, Dirk M. Hermann

“…Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. …”
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Virtual Screening as a Technique for PPAR Modulator Discovery by Stephanie N. Lewis, Josep Bassaganya-Riera, David R. Bevan

“…This review summarizes the high potential for obtaining further fundamental understanding of PPARγ biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results.…”
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Eosinophils: old cells, new directions by Alejandra Sanchez Santos, Iovanna Socorro Avila, Helena Galvan Fernandez, Sara Cazorla Rivero, Sara Cazorla Rivero, Angelina Lemes Castellano, Carlos Cabrera Lopez

“…In recent years, various biological therapies targeting these cells have been developed, altering the course of eosinophilic pathologies. …”
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European standard clinical practice recommendations for paediatric high-grade gliomas by Elwira Szychot, Géraldine Giraud, Darren Hargrave, Dannis van Vuurden, Jacques Grill, Veronica Biassoni, Maura Massimo, André O. Von Büren, Rejin Kebudi, Maria João Gil-da-Costa, Sophie Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Stephanie Bolle, Thankamma Ajithkumar, Mechthild Krause, Yasmin Lassen-Ramshad, Geert Janssens, Giovanni Morana, Ulrike Löbel, Shivaram Avula, Brigitte Bison, Maarten Lequin, Kristian Aquilina, Ulrich Thomale, Pelle Nilsson, Sami Bui-Quy Abu Hamdeh, Torsten Pietsch, Pascale Varlet, Thomas S. Jacques, Pieter Wesseling, David Jones, Uri Tabori, Anirban Das, David Mulligan, Francesca Kozmann, Christof M. Kramm

“…Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. …”
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Stretta Radiofrequency Treatment for GERD: A Safe and Effective Modality by Mark Franciosa, George Triadafilopoulos, Hiroshi Mashimo

“…Current treatments include lifestyle modifications, pharmacological therapies, surgical fundoplications, and, more recently, endoscopic procedures. …”
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Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke by Surajit Hansda, Hiranmoy Das

“…The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic stroke. …”
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The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration by Xianxu Zhang, Shicheng Li, Xin Liu, Zhong Ma, Qiang Zhang, Yuji Zhang, Jiangdong An, Zhiqiang Luo

“…Currently, clinical treatments for IVDD mainly focus on symptom management, with no available therapies capable of reversing or curing the disease. …”
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Using nonlinear model predictive control to find optimal therapeutic strategies to modulate inflammation by Judy Day, Jonathan Rubin, Gilles Clermont

“…In our simulations, NMPC successfully identifies patient-specific therapeutic strategies, based on simulated observations of clinically accessible inflammatory mediators, which outperform standardized therapies, even when the latter are derived using a general optimization routine. …”
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Cerebellar metastasis from colorectal cancer: a case report by Carla E. Angulo-Rojo, Luis J. Castillo-Gaxiola, Karen Gaxiola-Gastélum, Alma M. Guadrón-Llanos, Javier A. Magaña-Gómez, Diana L. Baldenebro-Félix, Diana L. Baldenebro-Félix

“…This case represents the first documented cerebellar metastasis from CRC in Mexico.ConclusionThis case highlights the altered metastatic patterns in CRC due to advanced therapies that extend survival. Clinicians should remain vigilant for metastasis to uncommon sites, such as the cerebellum, especially in patients with prolonged survival. …”
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The Role of the Microbiota in the Diabetic Peripheral Artery Disease by Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

“…Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. …”
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Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

“…Cancer therapies have attempted to target the transcription factor p53, a gene also described as the “guardian of the genome,” for decades. …”
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Immunobiologics in juvenile dermatomyositis: a systematic review of promising therapeutic advances by Aline Maria de Oliveira Rocha, Gabriel Fidelis Ribeiro, Juliana Capecce Silva

“…Material and Methods A systematic review was carried out comparing known treatments and immunobiological therapies, evaluating clinical improvement, adverse events and prognosis. …”
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Perbedaan Pengaruh Teknik Relaksasi Nafas Dalam Dan Kompres Hangat Dalam Menurunkan Dismenore Pada Remaja SMA Negeri 3 Padang by Vetty Priscilla, Dwi Christina Rahayu Ningrum, Lili Fajria

“…One non-pharmacological therapies that can be done to reduce dysmenorrhea relaxation techniques and breathing in the warm compresses. …”
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Tissue Engineering of the Urinary Bladder: Current Concepts and Future Perspectives by Vladimir Petrovic, Jablan Stankovic, Vladisav Stefanovic

“…The use of tissue engineering strategies that include the use of stem cells and artificially created scaffolds could give solutions for treatment of many disorders of the urinary bladder and transplantation therapies in the future. Although the research in this field is still in its infancy, there are some promising results that raise hope that the tissue engineering approach could offer long-term solutions for many issues in regenerative urology. …”
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Comprehensive analysis of targetable mutations and tumor microenvironment in urachal cancer by David J. Benjamin, Tolulope T. Adeyelu, Andrew Elliott, Sourat Darabi, Thomas Lee, Rana R. McKay, Matthew J. Oberley, Arash Rezazadeh Kalebasty

“…However, there remains a paucity of data on the effectiveness of immune checkpoint inhibitors or targeted therapies for urachal cancer. We analyzed the genomic profile of urachal cancer in order to identify potentially targetable mutations and evaluate the tumor microenvironment. 42 urachal samples were retrospectively analyzed. …”
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