Progression-free survival as a surrogate endpoint in myeloma clinical trials: an evolving paradigm by Charlotte Pawlyn, Fredrik H. Schjesvold, David A. Cairns, L. J. Wei, Faith Davies, Omar Nadeem, Haifaa Abdulhaq, Maria-Victoria Mateos, Jacob Laubach, Katja Weisel, Heinz Ludwig, S. Vincent Rajkumar, Pieter Sonneveld, Graham Jackson, Gareth Morgan, Paul G. Richardson

“…Abstract Measurement of overall survival (OS) remains the gold standard for interpreting the impact of new therapies for multiple myeloma in phase 3 trials. However, as outcomes have improved, it is increasingly challenging to use OS as the primary endpoint if timely approval of novel agents is to be ensured to enable maximum benefit for patients. …”
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Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis by Stergios Boussios, Vasiliki Kostadima, Anna Batistatou, Ioannis Tourkantonis, George Fotopoulos, Maria I. Argyropoulou, Nicholas Pavlidis

“…Use of disease-modifying therapies might contribute to an increased cancer risk in selected MS patients. …”
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The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? by Sonja S. Mojsilovic, Slavko Mojsilovic, Victor H. Villar, Juan F. Santibanez

“…Also, new macrophage-based cell therapeutic technologies recently developed using chimeric antigen receptor bioengineering are exposed, which may overcome all solid tumor physical barriers impeding the current adoptive cell therapies and contribute to developing novel cancer immunotherapies.…”
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Stem Cells Applications in Regenerative Medicine and Disease Therapeutics by Ranjeet Singh Mahla

“…The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. …”
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Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review by Brandon T. Mullins, Trevor Hackman

“…Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored.…”
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Brain Multimodality Monitoring: A New Tool in Neurocritical Care of Comatose Patients by Nudrat Tasneem, Edgar A. Samaniego, Connie Pieper, Enrique C. Leira, Harold P. Adams, David Hasan, Santiago Ortega-Gutierrez

“…Multimodality monitoring (MMM) encompasses various tools to monitor cerebral metabolism, perfusion, and oxygenation aimed at detecting these changes to help modify therapies before irreversible injury sets in. These tools include intracranial pressure (ICP) monitors, transcranial Doppler (TCD), Hemedex™ (thermal diffusion probe used to measure regional cerebral blood flow), microdialysis catheter (used to measure cerebral metabolism), Licox™ (probe used to measure regional brain tissue oxygen tension), and continuous electroencephalography. …”
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LGBT RIGHTS ARE HUMAN RIGHTS: SOCIAL WORK AND THE FIGHT AGAINST THE LGBTPHOBIC DISCOURSE OF “GAY CURE” by Leonardo Mozdzenski, Albert de Albuquerque

“…More particularly, this study turns its attention to the rhetorical appeals of ethos and pathos observed in those statements that were favorable to the proposition of therapies for sexual (re)orientation ("gay cure"), thus reproducing the hate speech, stigmatization and discrimination against the human rights of the members of the gender and sexuality diverse community. …”
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Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration by De-Zhi Zhao, Rui-Lin Yang, Han-Xiao Wei, Kang Yang, Yi-Bing Yang, Nuo-Xin Wang, Qian Zhang, Fang Chen, Tao Zhang

“…This paper systematically reviews the immunomodulatory (including bone immunomodulation) properties of MSCs and their role in the periodontal inflammatory microenvironment, summarizes the pathways and mechanisms by which MSCs and MSC-EVs have promoted periodontal regeneration in recent years, lists potential areas for future research, and describes the issues that should be considered in future basic research and the direction of development of “cell-free therapies” for periodontal regeneration.…”
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Biometallic ions and derivatives: a new direction for cancer immunotherapy by Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

“…In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape. …”
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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication by Hyeonseo Park, Tejal V. Patil, Jieun Lee, Hojin Kim, Seong-Jun Cho, Ki-Taek Lim

“…Our research proposes a platform that not only effectively addresses antibiotic-resistant infections but also contributes to advancements in wound healing therapies by enabling controlled antibacterial action with minimal toxicity.…”
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Quantifying hope: an EU perspective of rare disease therapeutic space and market dynamics by Emmanuelle Cacoub, Emmanuelle Cacoub, Nathalie Barreto Lefebvre, Dimitrije Milunov, Manish Sarkar, Soham Saha

“…Next-generation sequencing (NGS) offers hope for earlier and more accurate diagnoses, potentially leading to preventative measures and targeted therapies. In here, we explore the therapeutic landscape for rare diseases, analyzing drugs in development and those already approved by the European Medicines Agency (EMA). …”
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Funding for research on cryptococcal disease: an analysis based on the G-finder report by Iraine Duarte, Marcio L. Rodrigues

“…With reduced support for research, new therapies are unlikely to emerge. In this essay, we used the Policy Cures/G-finder platform as a reference database for funding research on cryptococcal disease. …”
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Natural products in the treatment of diabetic foot infection by Mohsen Nazari, Leili Shokoohizadeh, Mohammad Taheri

“…The review also explores challenges in integrating natural products into clinical practice and the potential for their use alongside or in place of traditional antibiotic therapies. Our findings suggest that natural products could play a crucial role in developing sustainable and effective treatment strategies for DFIs, especially in the face of rising antimicrobial resistance.…”
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Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…This review is an attempt to elucidate and correlate the regulatory role of phytochemicals on cellular signaling pathways implicated in oncogenesis and inflammatory responses, highlighting the significance and potential of phytochemical-based therapies for cancer prevention and treatment, as well as for managing inflammatory conditions. …”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…In recent years, three-dimensional (3D) in vitro models have emerged as powerful tools to study OSCC biology and evaluate targeted therapies in a more physiologically relevant context. …”
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Characterizing mutation-treatment effects using clinico-genomics data of 78,287 patients with 20 types of cancers by Ruishan Liu, Shemra Rizzo, Lisa Wang, Nayan Chaudhary, Sophia Maund, Marius Rene Garmhausen, Sarah McGough, Ryan Copping, James Zou

“…We systematically identified 776 genomic alterations associated with survival outcomes across 20 distinct cancer types treated with specific immunotherapies, chemotherapies, or targeted therapies. Additionally, we demonstrate how mutations in particular pathways correlate with treatment response. …”
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Expression Profiling of Transglutaminase 2 and Inflammatory Host Response in Aspergillus Fumigatus After Treatment with Curcuma Extracts by Omar Sadik Shalal

“…This pathogen is very capable of forming biofilms via developing hyphal walls radially. The current therapies are known for their limitations where they couldn’t target the proteins involved in undoing host response. …”
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Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK by Patrick M. Stuart, Tammie L. Keadle

“…We will document both differences and similarities that derive from this fundamental difference in these models with an eye towards possible vaccines and therapies that demonstrate promise in treating HSK.…”
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Rosacea-like skin reaction under treatment with dupilumab for atopic dermatitis by C. Grote, F. Zirkenbach, J. N. Wagner, M. Augustin

“…The findings suggest that alternative therapies, such as IL-13 inhibitors, should be considered when cutaneous side effects arise during dupilumab treatment.…”
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Intestinal Epithelial Cells as a Source of Inflammatory Cytokines and Chemokines by Andrew W Stadnyk

“…Closing this gap is necessary to take advantage of emerging therapies aimed at blocking chemokine function.…”
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