Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…Insightful information from this study is helpful for RA patients to consider using plant active substance therapies. For their efficacy and safety to be confirmed, more proof is needed.…”
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Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcino... by Jeffrey Hiken, Jon Earls, Kevin C. Flanagan, Rachel L. Wellinghoff, Michelle Ponder, David N. Messina, Jarret I. Glasscock, Eric J. Duncavage

“…Abstract Background While immune checkpoint inhibitor (ICI) therapies can significantly improve outcomes for patients with recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC), only about 15–20% benefit from such treatments. …”
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c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient by Jaafar Sadiq Jaafar, Hiba Muneer Abdual Hassan Al-Kafagi, Israa Hussein Hamzah

“…By modulating the levels of miRNA708-5p, it may be possible to regulate the expression of c-FLIP, thus enhancing the effectiveness of apoptosis-inducing therapies. This suggests the promising development of miRNA-based therapies as part of AML treatment strategies. …”
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Nanopore-based random genomic sampling for intraoperative molecular diagnosis by Francesco E. Emiliani, Abdol Aziz Ould Ismail, Edward G. Hughes, Gregory J. Tsongalis, George J. Zanazzi, Chun-Chieh Lin

“…The integrated approach not only enhances the accuracy of tumor diagnosis but also optimizes surgical planning and identifies potential molecular therapies, all within the critical intraoperative timeframe.…”
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Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study by Manuel Murie-Fernández, Mercedes Molleda Marzo

“…Improving our knowledge about the impact of restorative therapies employed in the rehabilitation of a stroke patient may help guide practitioners in prescribing treatment regimen that may lead to better post-stroke recovery and quality of life. …”
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Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro by Klaus Neef, Philipp Treskes, Guoxing Xu, Florian Drey, Sureshkumar Perumal Srinivasan, Tomo Saric, Erastus Nembo, Judith Semmler, Filomain Nguemo, Christof Stamm, Douglas B. Cowan, Antje-Christin Deppe, Maximilian Scherner, Thorsten Wittwer, Jürgen Hescheler, Thorsten Wahlers, Yeong-Hoon Choi

“…Choosing this route for the establishment of a sustainable, autologous source of cells for cardiac therapies holds the potential of being clinically more acceptable than transgenic manipulation of cells.…”
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Development of ptxD/Phi as a new dominant selection system for genetic manipulation in Cryptococcus neoformans by Muthita Khongthongdam, Tanaporn Phetruen, Sittinan Chanarat

“…Effective genetic manipulation tools are essential for understanding its biology and developing new therapies. However, current genetic tools, including the variation of versatile selectable markers, are limited. …”
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Corticosteroid Phobia: A Key Barrier to Treatment in Young Women with Idiopathic Granulomatous Mastitis by Lin W, Wang Q, Liu J, Tan Q

“…Women showed a high preference for non-corticosteroid therapies as alternative therapies. Providing more comprehensive and professional knowledge by physicians might be an effective method to attenuate corticosteroid phobia.Keywords: corticosteroid phobia, treatment adherence, idiopathic granulomatous mastitis, breast…”
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β-Caryophyllene and Statins in Bone Fracture Healing – A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…There is a critical need for alternative therapies that are cost-effective, safe, and easy to use. …”
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Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States by Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

“…Richard S Finn,1 Renuka Iyer,2 Richard S Kalman,3 Neehar D Parikh,4 Roniel Cabrera,5 Svetlana Babajanyan,6 Ahmed O Kaseb7 1Department of Medicine, University of California, Los Angeles, CA, USA; 2Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA; 3Department of Medicine, Einstein Medical Center, Philadelphia, PA, USA; 4Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; 5Department of Medicine, University of Florida Health, Gainesville, FL, USA; 6US Medical Affairs, Oncology, Bayer Healthcare, Whippany, NJ, USA; 7Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Richard S Finn, Department of Medicine, University of California, Los Angeles, CA, USA, Tel +1-310-586-2091, Email rfinn@mednet.ucla.eduIntroduction: While several systemic therapies are available for unresectable hepatocellular carcinoma (uHCC), there is a lack of granular real-world evidence to support the efficacy and safety of these therapies. …”
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Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment by Cristina Camps-Fajol, Debora Cavero, Jordi Minguillón, Jordi Surrallés

“…Targeting PPIs offers a promising approach in drug discovery and ongoing advancements in this field hold the potential to provide highly specific therapies for a wide range of complex diseases. Despite the development of PPI modulators is challenging, advances in the genetic, proteomic and computational level have facilitated their discovery and optimization. …”
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抗肿瘤靶点研究及治疗策略 by 江振友

“…抗肿瘤靶向治疗（“targeted” cancer therapies）是在特异性靶向工具的引导下，小分子药物或抗体自身对肿瘤细胞及其微环境的攻击或激活机体免疫反应。…”
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Developability considerations for bispecific and multispecific antibodies by Alaa Amash, Gesa Volkers, Patrick Farber, Daniel Griffin, K. Shawn Davison, Allison Goodman, Raffi Tonikian, Aaron Yamniuk, Bryan Barnhart, Tim Jacobs

“…Early assessment of candidate developability enables demotion of antibodies with low potential and promotion of the most promising candidates for further development. Protein-based therapies have a stringent set of developability requirements in order to be competitive (e.g. high-concentration formulation, and long half-life) and their assessment requires a robust toolkit of methods, few of which are validated for interrogating bsAbs/msAbs. …”
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The Peripherin Gene Regulates the Migration of Bone Marrow Mesenchymal Stem Cells in Wuzhishan Mini Pigs by Zheng Feng, Wentong Li, Ying Xia, Hui Yu, Hua Li, Kui Li, Yulian Mu

“…Increasing the migratory capacity of the implanted mesenchymal stem cells (MSCs) is a major challenge in developing successful cell transplantation therapies. Nevertheless, the regulatory factors involved in the migration of BMMSCs remain largely unknown. …”
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NTRK-rearranged spindle cell tumor with SPECC1L-NTRK3 fusion in the thoracic spine: a case report by Mi Zhou, Huaiyuan Xu, Jianxiong Niu, Qibing Yang, Anqi Wang, Hao Wu, Xiangqin Wang, Meng Yang, Jinxin Hu, Qinglian Tang, Jin Wang

“…This case underscores the diagnostic and therapeutic importance of next-generation sequencing in identifying tumor-specific genetic alterations and selecting targeted therapies. Following 1 month of entrectinib treatment, the patient experienced considerable tumor shrinkage and symptomatic improvement. …”
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PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases by Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen

“…These findings suggest that PPARγ is a novel target in the treatment of AMH and that further work on this transcription factor may lead to new therapies for chronic airway inflammatory diseases.…”
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Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation by Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti-Broceta, David C. Hay, Stuart J. Forbes, Victoria L. Gadd, Neil O. Carragher

“…These findings could significantly advance research on liver cell regeneration mechanisms and facilitate the development of cell-based and small-molecule therapies.…”
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Deep Brain Stimulation in Parkinson’s Disease: New and Emerging Targets for Refractory Motor and Nonmotor Symptoms by Dustin Anderson, Grayson Beecher, Fang Ba

“…Many pharmacological therapies now exist to successfully treat PD motor symptoms; however, as the disease progresses, it often becomes challenging to treat with medications alone. …”
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Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling by María Paz Ocaranza, Jorge E. Jalil

“…Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hypertension, heart failure, and CV remodeling but in spite of their success the prevalence of end-organ damage and residual risk remain still high. …”
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Early Posttransplant Isolated v1 Lesion Does Not Need to Be Treated and Does Not Lead to Increased Fibrosis by Irfan Moinuddin, Bijin Thajudeen, Amy Sussman, Machaiah Madhrira, Erika Bracamonte, Mordecai Popovtzer, Pradeep V. Kadambi

“…Although it is suggested that most cases of isolated v1 lesions will respond to corticosteroids or T cell depleting therapies, some cases will improve with conservative management. …”
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