Cholangiocyte organoids for disease, cancer, and regenerative medicine by Munemasa Nagao, Akihisa Fukuda, Hirotaka Kashima, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Tomonori Masuda, Yukiko Hiramatsu, Yu Muta, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Hiroshi Seno

“…Additionally, COs have the potential to repair bile duct injuries and facilitate transplantation therapies. This review also discusses the use of organoids in genetically engineered mouse models to provide mechanistic insights into tumorigenesis and cancer progression. …”
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Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…At present, it is not clear what causes this progression, and there are no current therapies that have been successful in preventing PD progression. …”
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Third Swiss Annual Meeting on HER2-Positive Breast Cancer: Recent Advances and New Challenges by Marcus Vetter, Christian Kurzeder

“…The development of antibody-based therapies has transformed the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
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A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina by Gaia Ziraldo, Sara Cupini, Valentina Sesti, Emanuela Delfino, Guglielmo Lanzani, Chiara Bertarelli, Fabio Benfenati, Stefano Di Marco

“…Abstract The lack of effective therapies for visual restoration in Retinitis pigmentosa and macular degeneration has led to the development of new strategies, such as optogenetics and retinal prostheses. …”
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Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

“…Therefore, development of new anti-HSV-1 compounds or therapies is key to addressing the issue of resistance. …”
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Cinnamon treatment shows promise for glycemic control but may cause adverse effects in some people by Laura del Bosque-Plata, Claudia Gragnoli

“…In particular, there are concerns about the dose, especially when used in the context of anticoagulant or antiplatelet therapies.…”
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Bicuspid Aortic Valve and Thoracic Aortic Aneurysm: Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype by Robert B. Hinton

“…A better understanding of the BAV-TAA association will provide an opportunity to leverage molecular information to modify clinical care through more sophisticated diagnostic testing, improved counseling, and ultimately new pharmacologic therapies.…”
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Brain-derived neurotrophic factor – a key player in the gastrointestinal system by Arjun Singh

“…Advancing knowledge of BDNF biology and mechanisms of action may lead to new therapies based on harnessing the gut trophic effects of this neurotrophin.…”
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Monoclonal Antibodies for Treatment of COVID-19: An Updated Review of Current Evidence by Saurabh Nimesh, Pratibha Kumari, Rohit Kumar, Gosiya Gosiya, Md. Quamuddin, Md. Iftekhar Ahmad

“…Furthermore, we explore the ongoing research and development efforts to optimize mAb-based therapies for COVID-19. …”
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The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review by Lize Evens, Hanne Beliën, Dorien Deluyker, Annelies Bronckaers, Pascal Gervois, Marc Hendrikx, Virginie Bito

“…Stem cell-based regenerative therapies hold great promises to treat a wide spectrum of diseases. …”
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Optimizing non-invasive vagus nerve stimulation for treatment in stroke by Sheharyar S. Baig, Samantha Dorney, Mudasar Aziz, Simon M. Bell, Ali N. Ali, Li Su, Jessica N. Redgrave, Arshad Majid

“…There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. …”
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Certolizumab pegol in severe hidradenitis suppurativa in pregnancy: A case report by Paolo Gisondi, Elena Montalto, Tea Curic, Elisabetta Danese, Francesco Bellinato, Giampiero Girolomoni

“…During pregnancy, the management of hidradenitis suppurativa becomes demanding due to the need of safety therapies. Certolizumab pegol is a pegylated monoclonal TNF-α inhibitor that lacks the fragment crystallizable region preventing active placental transfer and could be used in pregnancy and lactation if clinically needed and is label for chronic plaque psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease. …”
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Functional dyspepsia and gastroparesis: are they distinct disorders, a spectrum of diseases or one disease? by Simon Keely, Nicholas J Talley, Michael Potter, Kerith Duncanson, Stella-Maris Egboh

“…Improved understanding of the similarities, differences and overlap is likely to help guide the development of objective biomarkers and better-targeted therapies.…”
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Advances in Neoteric Modular Tissue Engineering Strategies in Regenerative Dentistry by Nathalie Steffy Ponce Reyes, Myrian Margarita Grijalva Palacios, Carlos Mauricio Saeteros Cárdenas, Adriana Katherine Quezada Quiñonez

“…Given the volatility of the efficacy and long-term safety of regenerative dentistry, financial models are needed to help facilitate patient access to these therapies. Impediments also arise during the manufacturing of cellular products and with approved regulatory establishments.…”
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Therapeutic Approaches for Peripheral and Central Neuropathic Pain by Délia Szok, János Tajti, Aliz Nyári, László Vécsei

“…In drug-refractory cases, interventional, physical, and psychological therapies are available. This review was structured based on a PubMed search of papers published in the field from 2010 until May 2019.…”
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Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies by Tiffany Tang, Kevin Tay, Richard Quek, Miriam Tao, Soo Yong Tan, Leonard Tan, Soon Thye Lim

“…Nevertheless, there has been development in the understanding of T-cell lymphomas and how they should be managed; FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. …”
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Systemically modeling the dynamics of plasma insulin insubcutaneous injection of insulin analogues for type 1 diabetes by Jiaxu Li, Yang Kuang

“…Several pharmacokineticalmodels have been proposed, and some are applied clinically inmodeling various insulin therapies. However, their plasma insulinconcentration must be computed separately from the models' output.Furthermore, minimal analytical study was performed in theseexisting models. …”
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Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia by Mário Angelo Claudino, Kleber Yotsumoto Fertrin

“…The authors review what is known about the deleterious effects of sickling on the genitourinary tract and how the role of cyclic nucleotides signaling and protein kinases may help understand the pathophysiology underlying these manifestations and develop novel therapies in the setting of urogenital disorders in sickle cell disease.…”
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Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells by Karen Bieback, Sven Kinzebach, Marianna Karagianni

“…However, translating basic research into routine therapies is a complex multistep process which necessitates product regulation. …”
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Drug-induced psoriasis by Sunil Dogra, Divya Kamat

“…Many of the biological agents and targeted therapies available today can trigger psoriasis by activating signaling pathways. …”
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