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19341
Contemporary treatment of right ventricular failure
Published 2025-02-01“…This review explores the etiology, mechanisms, and pathophysiology of RVF, drugs directly targeting the RV myocardium, the intricate biological processes between RV and pulmonary vascular remodeling, surgical and device therapies, and future perspectives on managing RVF.…”
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19342
State of the Art of Fuzzy Methods for Gene Regulatory Networks Inference
Published 2015-01-01“…They provide viable computational tools for inferring GRNs from gene expression data, thus contributing to the discovery of gene interactions responsible for specific diseases and/or ad hoc correcting therapies. Increasing computational power and high throughput technologies have provided powerful means to manage these challenging digital ecosystems at different levels from cell to society globally. …”
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19343
Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies
Published 2025-01-01“…Overall, the conclusions of this review revealed the therapeutic potential of copper-based therapies that target cuproptosis for the development of strategies for the treatment of HF.…”
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19344
Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up
Published 2018-01-01“…Antifungal and anti-inflammatory therapies are usually ineffective, and surgical intervention contains a high morbidity risk. …”
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19345
Bullous pemphigoid and morphea: Coexistence or an incidental association
Published 2024-12-01“…Although the etiology of BP remains uncertain, various diseases or treatments may be associated with the onset of BP, including neurological disorders, ultraviolet therapies, and drugs. In this report, we describe an old diabetic patient with a history of plaque morphea who developed BP while in remission from treatment.…”
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19346
Successful Rehabilitation of Partial Edentulous Maxilla and Mandible with New Type of Implants: Molecular Precision Implants
Published 2014-01-01“…Atraumatic extraction, implant placement in extraction socket, and an immediate prosthesis have been proposed as alternative therapies to maintain the volume and contours tissue and reduce time and cost of treatment. …”
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19347
Septo-Optic Dysplasia Diagnosed in a Newborn Infant with Normoglycemia: The Importance of Thorough Physical Examination
Published 2021-01-01“…Further testing revealed additional pituitary hormone deficiencies, and the infant was started on multiple hormone replacement therapies. Magnetic resonance imaging identified absent septum pellucidum, pointing of the frontal horns, and optic nerve hypoplasia. …”
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19348
Nanoparticles and Inflammation
Published 2011-01-01“…Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. …”
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19349
Pathological Plasticity in Fragile X Syndrome
Published 2012-01-01“…Characterizing early developmental deficits in plasticity is fundamental to develop therapies that not only treat symptoms but also minimize the developmental pathology of the disease.…”
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19350
Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability
Published 2016-01-01“…In the near future, it may be possible to specifically target these specific pathways to develop novel therapies for gastrointestinal disorders associated with increased gut permeability.…”
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19351
Using omega 3 as an anti-aging treatment
Published 2020-12-01“…The available literature shows the effect and benefit of these fatty acids in the aging process, which constitute clinical therapies at the dermatological level and in areas of plastic surgery. …”
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19352
Antifibrotic Activity of Acylated and Unacylated Ghrelin
Published 2015-01-01“…Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. …”
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19353
New Therapeutic Targets for Mood Disorders
Published 2010-01-01“…Overall, an improved understanding of the neurobiological underpinnings of mood disorders is critical in order to develop targeted treatments that are more effective, act more rapidly, and are better tolerated than currently available therapies.…”
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19354
Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms
Published 2017-01-01“…The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.…”
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19355
Bronchus-associated lymphoid tissue in lung transplantation: a facilitator of rejection or regulator of tolerance?
Published 2025-02-01“…Insights gained from studies that focus on the role of BALT in lung transplantation may be harnessed to develop new therapies.…”
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19356
Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population
Published 2025-01-01“…We then used this virtual population to predict the results of clinical trials on the basis of disease severity, dosing regimen, time since diagnosis, and co-administered background therapies. The virtual population captured the effect of changes in trial design and patient subpopulation on clinical response. …”
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19357
A Case Report of Acupuncture Treatment on Antiphospholipid Syndrome Complicated by Cerebral Infarction
Published 2017-08-01“…In total, the patient underwent 24 session of acupuncture along with regular therapies.Results:After four acupuncture sessions, the patient regained spontaneous breathing, weaned off mechanical ventilation subsequently and successfully extubated. …”
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19358
Structure‐based computational design of antibody mimetics: challenges and perspectives
Published 2025-02-01“…The design of antibody mimetics holds great promise for revolutionizing therapeutic interventions by offering alternatives to conventional antibody therapies. Structure‐based computational approaches have emerged as indispensable tools in the rational design of those molecules, enabling the precise manipulation of their structural and functional properties. …”
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19359
Pendred syndrome: Advances in diagnostics and unresolved therapeutic challenges
Published 2025-01-01“…Despite our enhanced understanding of the disease, the development of targeted and efficacious therapies for Pendred syndrome has yet to be achieved. …”
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19360
Thyroid Mutations and Implications for Clinical Treatment
Published 2024-12-01“…The identification of aggressive diseases through molecular testing has revolutionized risk stratification and treatment options, allowing for targeted therapies that match-specific genetic alterations. …”
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