The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy by Carlos Rodrigo Zárate-Bladés, Celio Lopes Silva, Geraldo A. Passos

“…This paper analyzes how transcriptomics are supporting the translation of basic research into therapies by resolving three key issues in the fight against TB: (a) the discovery of biomarkers, (b) the explanation of the variability of protection conferred by BCG vaccination, and (c) the development of new immunotherapeutic strategies to treat TB.…”
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CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…Despite therapeutic complexities, recent advancements in genetic testing and targeted therapies, notably Janus kinase inhibitors, offer promising avenues for improved patient outcomes. …”
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Cosmetic filler-induced hair loss: case series and literature review by Yutong Xie, Xi Chen, Aihua Wei

“…The third case described another female who experienced alopecia areata-like hair loss after autologous fat grafting, and received combined therapies including corticosteriod, 5% minoxidil and microneedling.Results All patients got gradual hair regrowth with treatments.Conclusions Early recognition and intervention are crucial to prevent permanent hair follicle damage. …”
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Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice by Chengfen Wang, Yujing Xia, Yuanyuan Zheng, Weiqi Dai, Fan Wang, Kan Chen, Jingjing Li, Sainan Li, Rong Zhu, Jing Yang, Qin Yin, Huawei Zhang, Junshan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

“…Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.…”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Additionally, it discusses the potential benefits of combining therapies that boost Treg cells with belatacept to increase the effectiveness of immunosuppression and improve graft outcomes.…”
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THE USE OF ANTIBIOTICS IN THE DENTAL FIELD – THE PHENOMENON OF ANTIBIOTIC RESISTANCE by Alina Anton, Iasmina Alexandra Predescu, Nuca Cristina, Mariana Păcurar, Ștefania Dinu

“…Antimicrobial resistance is an alarming problem that involves important consequences, especially in managing therapies for patients with life-threatening infections. …”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. …”
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From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments by Zhenlin Li, Zhenlin Li, Zhenlin Li, Zhenlin Li, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fujin Zhou, Fujin Zhou, Fujin Zhou, Dekun Song, Dekun Song, Dekun Song, Lunhui Chang, Lunhui Chang, Lunhui Chang, Lunhui Chang, Weiying Liu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang, Guolong Zhang

“…In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. …”
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Human Herpesviridae Methods of Natural Killer Cell Evasion by Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady

“…Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.…”
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Circulating T Cell Subsets in Type 1 Diabetes by Aldo Ferreira-Hermosillo, Paola Santana-Sánchez, Ricardo Vaquero-García, Manuel R. García-Sáenz, Angélica Castro-Ríos, Adriana K. Chávez-Rueda, Rita A. Gómez-Díaz, Luis Chávez-Sánchez, María V. Legorreta-Haquet

“…These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies.…”
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L’intervention féministe sous l’influence de l’intersectionnalité : enjeux organisationnels et communicationnels au sein des organismes féministes au Québec by Isabelle Marchand, Christine Corbeil, Carole Boulebsol

“…In Quebec, feminist intervention was spread significantly in the mid-1970s and presented itself as a therapeutic and political alternative to traditional therapies in the field of mental health and the fight against gender-based violence, to support women and defend their rights. …”
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Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers by Artemijs Sceglovs, Artemijs Sceglovs, Ingus Skadins, Marco Chitto, Juta Kroica, Kristine Salma-Ancane, Kristine Salma-Ancane

“…The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. …”
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Regulatory role of PPAR in colorectal cancer by Cong Wang, Tingcong Lv, Binghui Jin, Yang Li, Zhe Fan

“…An in-depth understanding of the pathways related to PPARs may provide new ways of developing effective therapies for CRC with PPARs as potential targets.…”
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Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis by Jingbin Zhou, Zhihong Zhao, Chen He, Feng Gao, Yu Guo, Feng Qu, Yujie Liu

“…We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.…”
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An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) by Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem

“…This review provides a comprehensive overview of the recent advancements in quinoxaline-based therapies, underscoring their potential impact on modern drug discovery and therapeutic applications.…”
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Leukocytes: The Double-Edged Sword in Fibrosis by Jakub Kryczka, Joanna Boncela

“…Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. …”
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Alternative Splicing Programs in Prostate Cancer by Claudio Sette

“…Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. …”
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Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors by Eric Lee, H. Leon Pachter, Umut Sarpel

“…Hepatic arterial embolization procedures take advantage of the arterial supply of NET metastases. The goals of these therapies are twofold: to increase overall survival by stabilizing tumor growth, and to reduce the morbidity in symptomatic patients. …”
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The Role of Purinergic Receptors in Cancer-Induced Bone Pain by Sarah Falk, Maria Uldall, Anne-Marie Heegaard

“…Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. …”
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Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? by Arunotai Siriussawakul, Lucinda I. Chen, John D. Lang

“…Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist. This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. …”
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