Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells by John Michel, Matthew Penna, Juan Kochen, Herman Cheung

“…Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. …”
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Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis by Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E. Ingber

“…This research provides new insights into the mechanisms underlying vaginal dysbiosis and opens avenues for developing targeted therapies and diagnostic tools to enhance women’s reproductive health.…”
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NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics by Yuzhou Liu, Ying Wang, Ping Yan, Ning Cui, Kejin Xu, Da Liu, Yuan Tian, Lingling Cao

“…Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammation, <i>pyroptosis</i>, and OA progression are tightly linked. …”
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A large histological images dataset of gastric cancer with tumour microenvironment annotation for AI by Shenghan Lou, Jianxin Ji, Huiying Li, Xuan Zhang, Yang Jiang, Menglei Hua, Kexin Chen, Kaiyuan Ge, Qi Zhang, Liuying Wang, Peng Han, Lei Cao

“…Decomposing the complex TME from histological images into its constituent parts is crucial for evaluating its patterns and enhancing GC therapies. Although various deep learning methods were developed in medical field, their applications on this task are hindered by the lack of well-annotated histological images of GC. …”
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Marburg variant of multiple sclerosis: A young women case report by Mohammed Alaa Jameel, Wameth Alaa Jamel, Alaa Jameel Hasan, Riyam Amer Hammood Alkhuzaie

“…Therefore, aggressive therapies can be used to further suppress the inflammatory process to prevent further neurological damage.…”
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How to assess orodispersible film quality? A review of applied methods and their modifications by Wasilewska Katarzyna, Winnicka Katarzyna

“…Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. …”
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Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease by K. V. Ivashkin, V. R. Grechishnikova, M. S. Reshetova, V. T. Ivashkin

“…Further research into the SIBO-IBS interface is required for developing optimal probiotic-based therapies.…”
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B Cells in Autoimmune Diseases by Christiane S. Hampe

“…We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells.…”
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Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

“…The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. …”
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Resistant Ventricular Arrhythmia and the Role of Overdrive Pacing in the Suppression of the Electrical Storm by Mohamed Magdi, Mahmood Mubasher, Hakam Alzaeem, Tahir Hamid

“…Ventricular arrhythmia storm is a state of cardiac instability characterized by multiple ventricular arrhythmias or multiple ICD therapies within a 24-hour duration. Management of this life-threatening state depends on the reversal of the cause besides either electrical or medical management of the arrhythmia. …”
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Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome by Jin-Na Wang, Tian-Qi Li, Qin-Mei Liu, Yu-Yan Wu, Ming-Yu Luo, Zhen-Yu Gong

“…SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. Evidence suggests that SFTSV circulates between ticks and animals in nature and is transmitted to humans by tick bites. …”
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In search of Alzheimer’s disease treatment methods: trends of clinical trials by G. Pakulaitė, V. Regelskytė, E. Audronytė, J. Kuzmickienė, G. Kaubrys

“…More than two thirds (70%) of these agents are developed as disease-modifying therapies. Their mechanisms of action are targeted mainly to amyloid and tau related pathology. …”
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Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets by Jean-Ehrland Ricci

“…We discuss innovative combinations of immunotherapy, cellular therapies, and metabolic interventions that could optimize the efficacy of existing treatment protocols.…”
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Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.…”
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Commentary to F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots—Are We Getting There? by Andrew W. Stephens MD, PhD, Norman Koglin PhD, Ludger M. Dinkelborg PhD

“…Areas of future research and potential clinical applications are discussed that may lead to an improved detection of critical thromboembolic events and an optimization of available antithrombotic therapies by tracking activated platelets.…”
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The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization by Branislava Janic, Ali S. Arbab

“…Due to their ability to self-renew, circulate, home to the ischemic sites, and differentiate into mature endothelial cells, EPCs hold enormous potential to be used as a diagnostic and/or therapeutic agent in antitumor therapies. Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe.…”
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Pediatric Migraine by Ubaid Hameed Shah, Veena Kalra

“…Biofeedback and other nonmedicinal therapies are being used with promising results.…”
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Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. …”
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Pivotal Roles of GM-CSF in Autoimmunity and Inflammation by Aoi Shiomi, Takashi Usui

“…This review summarizes the latest knowledge of GM-CSF and its relationship with autoimmune and inflammatory diseases. The potential therapies targeting GM-CSF as well as their possible side effects have also been addressed in this review.…”
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Prefibrotic Myelofibrosis Presenting with Multiple Cerebral Embolic Infarcts and the Rare MPL W515S Mutation by Stephen E. Langabeer, Lisa Lee Tokar, Laura Kearney, Cathal O’Brien, Kowshika Thavarajah, Aisling Barrett, John McManus, Hilary O’Leary

“…Thrombolytic and cytoreductive therapies resulted in a favorable outcome and follow-up. …”
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