Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization by Yanting Cao, Danping Fan, Yiqing Yin

“…A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies.…”
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Pure White Cell Aplasia and Necrotizing Myositis by Peter Geon Kim, Joome Suh, Max W. Adelman, Kwadwo Oduro, Erik Williams, Andrew M. Brunner, David J. Kuter

“…With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.…”
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Evasion of Apoptosis as a Cellular Stress Response in Cancer by Simone Fulda

“…Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. …”
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Transcatheter Tricuspid Valve Replacement: Current Options and Future Perspectives by Guido Del Monaco, Gianluca Mincione, Alessandro Sticchi, Bernhard Reimers, Antonio Colombo, Antonio Mangieri

“…Traditionally managed medically and surgically, transcatheter therapies are now an emerging option, especially in patients with prohibitive surgical risk due to age or comorbidities. …”
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Combination of Dabrafenib and Trametinib for the Treatment of Relapsed and Refractory Multiple Myeloma Harboring BRAF V600E Mutation by Rūta Čepulytė, Andrius Žučenka, Valdas Pečeliūnas

“…Multiple myeloma (MM) is an incurable plasma cell neoplasia characterized by relapsed and/or refractory (R/R) disease course, which poses a major therapeutic challenge. New therapies, including BRAF V600E mutation targeting, may become a new treatment option for R/R MM. …”
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Modulation of Immunity by Antiangiogenic Molecules in Cancer by Magali Terme, Orianne Colussi, Elie Marcheteau, Corinne Tanchot, Eric Tartour, Julien Taieb

“…Interestingly, immune parameters or their modulation during treatment could serve as potential biomarkers of response or resistance to anti-angiogenic therapies.…”
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Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources by Xiaolong Ji, Jianhang Guo, Tengzheng Cao, Tingting Zhang, Yanqi Liu, Yizhe Yan

“…Diabetes mellitus (DM) is a common multifactorial disease, causing various complications, such as chronic metabolism. The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. …”
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Therapeutic applicability of helminths in autoimmune diseases – literature overview by Jacek Zwiernik, Tomasz Arłukowicz, Beata Zwiernik, Tomasz Matyskieła, Marta Gimeła-Dargiewicz, Agnieszka Rakowska, Beata Januszko-Giergielewicz, Ewa Rotkiewicz

“…Making use of their ability for immunomodulation may lead to the introduction of effective therapies for autoimmune diseases. This paper presents chronologically attempts to treat autoimmune diseases not only of the gastrointestinal tract, but also of the nervous and endocrine systems, which have been undertaken for decades. …”
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La guérison dans Everyman by Martine Yvernault

“…Dying―holy dying―and healing, set against the social and historical backcloth of medieval Europe with its changes, tragedies and outbreaks of plague, imply a progress leading to the spiritual transformation of Everyman, probably a member of the merchant class, also showing the audience that the spiritual part of the body, promised to decay, may be amended and healedchemin, cheminement, Everyman et saint Paul, guérison, symbolisme de l’eau, thérapie…”
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Management of refractory postpneumonectomy empyema with bronchopleural fistula by Oleg Shamilevich Kesaev, Dmitry Borisovich Giller, Sergey Sergeevich Saenko, Elham Pahlevani, Lyudmila Petrovna Severova

“…This clinical case demonstrates the complications of BSF with tuberculosis empyema treatment in spite of there existing many alternative therapies. The need for new more effective treatments is highlighted, as well as safe and less technically difficult interventions which could assist patients with BSF.…”
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Polymer and nanocomposite fillers as advanced materials in biomedical applications by Angeline Julius, Suresh Malakondaiah, Raghu Babu Pothireddy

“…The exploration of supramolecular polymer nanocomposites remains in its infancy but holds immense promise for advancing nanomedical therapies. This review underscores the need for focused research on biocompatibility, functional predictability, and the integration of polymer nanocomposites into clinical diagnostics and therapeutic applications to bridge current limitations and unlock their full potential in the field of biomedicine.…”
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Improving the Fharmacology Teaching-Learning Process in the Formation of Medicine Doctors: Conceptions, Challenges and Perspectives by Pedro Miguel Milián Vázquez, María Magdalena López Rodríguez del Rey

“…Pharmacology is a discipline that provides medicine doctors with a scientific support for therapies while applying an integral treatment to patients. …”
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Mathematical modeling of cyclic treatments of chronic myeloid leukemia by Natalia L. Komarova

“…We define a condition on the drugs' potencies which allowsfor a relatively successful application of cyclic therapies. We findthat the best strategy is to start with the stronger drug, but uselonger cycle durations for the weaker drug. …”
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Imitation and dyspraxia in autism: Clinical and therapeutic implications by Leonardo Massoni

“…Meanwhile, by employing intense interaction, imitation, or “expressive art” therapies, which respond intimately to motor activities, some improvements could be made for these symptoms of ASD.Starting from these premises, the aim of this short communication is to discuss some works on the clinical basis and therapeutic perspectives of imitation defects and dyspraxia in autism spectrum disorder.…”
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Acute Chest Syndrome Progressing to ARDS in a Patient of 25-Week Gestation by Jefferson Chambers, Nichole Smith, Matthew Sehring, Subramanyam Chittivelu

“…We present a case of a 20-year-old patient with known sickle cell disease who was at 25-week gestation and developed acute chest syndrome refractory to conventional therapies and requiring emergency cesarean section. …”
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Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response by Florent Duval, Jorge E. Moreno-Cuevas, María Teresa González-Garza, Carmen Maldonado-Bernal, Delia Elva Cruz-Vega

“…The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. …”
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Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording by Gota Shinohara, Tasuku Kayama, Ayumu Okui, Wataru Oda, Atsushi Nishikawa, Alexander Loesing, Nahoko Kuga, Takuya Sasaki, Hiroto Sekiguchi

“…This scalable, flexible tool overcomes integration challenges, advancing optogenetic research and opening avenues for exploring neural dynamics and targeted neurological therapies.…”
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Sex/gender analysis in systematic reviews. Critical review and recommendations by Raúl Aguilera Eguía, Olga Patricia López Soto, Ángel Roco Videla, Brenda Herrera Serna, Héctor Fuentes Barria, Lorena Gerli Candia

“…Sex/gender analysis allows for the detection of subtle differences in therapeutic effects, thereby enriching clinical practice and promoting the design of personalized therapies. However, its proper incorporation faces challenges, such as confusion between “sex” and “gender” and the lack of contextualized data. …”
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Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions by Linjuan Guo, Dexi Wu, Wengen Zhu

“…By emphasizing the need for further research, this review aims to enhance understanding of ANK2’s role in heart disease and guide the development of effective therapies.…”
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Desensitization: Overcoming the Immunologic Barriers to Transplantation by Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan

“…Over the last decade, several immunomodulatory therapies have emerged allowing for increased access to kidney transplantation for the immunologically disadvantaged group of HLA sensitized end stage kidney disease patients. …”
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