Imaging Reactive Oxygen Species in Arthritis by Wei-Tsung Chen, Ching-Hsuan Tung, Ralph Weissleder

“…In vivo chemiluminescence imaging is expected to become a useful modality to elucidate the role of ROS in the pathogenesis of arthritides and in determining therapeutic efficacy of protective therapies.…”
Get full text

Pulmonary Complications in Patients with Severe Brain Injury by Kiwon Lee, Fred Rincon

“…Prevention strategies and current and future therapies need to be implemented to avoid and treat the development of these life-threatening medical complications.…”
Get full text

Mouse Models of Prostate Cancer by Kenneth C. Valkenburg, Bart O. Williams

“…These models provide a platform for finding novel therapies to treat human patients afflicted with prostate cancer as well as those who have debilitating bone metastases. …”
Get full text

Oral Manifestations of Exudative Erythema Multiforme in a Patient with COVID-19 by Zana Sllamniku Dalipi, Fatmir Dragidella, Donika Kastrati Dragidella

“…The presence of oral lesions in the late stage of COVID-19 could be related to weak patient immunity or related therapies.…”
Get full text

Cytomegalovirus Colitis with Common Variable Immunodeficiency and Crohn’s Disease by Betül Ünal, Cumhur İbrahim Başsorgun, Sinem Çil Gönülcü, Aslı Uçar, Fatih Çelik, Gülsüm Özlem Elpek

“…Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day. …”
Get full text

A Multiplex Polymerase Chain Reaction Assay for the Detection of Herpes Simplex Virus, Cytomegalovirus, and Varicella-Zoster Virus in Cerebrospinal Fluid by Tatjana Luzius, Samuel D. Jeske, Julia Baer, Uta Goelnitz, Ulrike Protzer, Jochen M. Wettengel

“…Early detection of treatable viral pathogens such as Herpes simplex virus (HSV), Cytomegalovirus (CMV), and Varicella-zoster virus (VZV) is essential for initiating appropriate therapies. However, multiplex PCRs for the rapid and simultaneous detection of these pathogens are scarce due to the complex PCR design and the elaborate validation process using cerebrospinal fluid samples. …”
Get full text

The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections 2016 by Roberta Rizzo, Enrico Fainardi, Nathalie Rouas-Freiss, Fabio Morandi

Get full text

Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites by Hong Zheng, Zhangping Tan, Wenyue Xu

“…In contrast, the pre-erythrocytic stage is clinically asymptomatic and could be an excellent target for preventive therapies. Although the robust host immune responses limit the development of the liver stage, malaria parasites have also evolved strategies to suppress host defenses at the pre-erythrocytic stage. …”
Get full text

Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases by Jiani Li, Jichao Sha, Liwei Sun, Dongdong Zhu, Cuida Meng

“…Moreover, we also discussed directions for future clinical treatment approaches, with a particular emphasis on Treg cell-targeted therapies for allergic disorders.…”
Get full text

The Effectiveness of Ketamine in Pediatric Acute Deafferentation Pain after Spinal Cord Injury by Devina G. Shiwlochan, Misty Shah, Khushboo Baldev, Donna-Ann Thomas, Maxime Debrosse

“…The literature on effective therapies for pediatric deafferentation pain, especially in the setting of spinal cord injury, is scarce. …”
Get full text

Severe Corticosteroid-Induced Ocular Hypertension Requiring Bilateral Trabeculectomies in a Patient with Takayasu’s Arteritis by Anna Maria Gruener, Pranev Sharma, Sally Ameen, Faisal Ahmed

“…As she did not sufficiently respond to ocular antihypertensive therapies, bilateral enhanced trabeculectomies were required to normalize her intraocular pressures. …”
Get full text

Upper Extremity Deep Vein Thromboses: The Bowler and the Barista by Seth Stake, Anne L. du Breuil, Jeremy Close

“…A literature review explores the recommended therapies for upper extremity deep vein thromboses.…”
Get full text

Démons et déments. Quand Détective enquête sur la folie by Marc Renneville

“…Arbitrary confinement, escape or exit of dangerous patient, new therapies and prevention of madness are all questions relayed by the national press. …”
Get full text

Endothelial-Mesenchymal Transition in Regenerative Medicine by Damian Medici

“…As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. …”
Get full text

Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention by Martin R. Jadus, Josephine Natividad, Anthony Mai, Yi Ouyang, Nils Lambrecht, Sandor Szabo, Lisheng Ge, Neil Hoa, Maria G. Dacosta-Iyer

“…Lung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. …”
Get full text

Pathological Features of New Animal Models for Primary Biliary Cirrhosis by Koichi Tsuneyama, Yuki Moritoki, Kentaro Kikuchi, Yasuni Nakanuma

“…Knowledge and understanding of the strengths and the limitations of each animal model have led to the development of promising therapies and novel tools to characterize these clinical conditions. …”
Get full text

Cytokines in inflammatory bowel disease by P. L. Beck, J. L. Wallace

“…The evidence for and against a role for particular cytokines in intestinal inflammation is reviewed, as is the experimental and clinical data suggesting that cytokines are rational targets for the development of new therapies.…”
Get full text

Follicular Regulatory T Cells in Systemic Lupus Erythematosus by Xin Xia, Jun Yang, Shengjun Wang

“…This review focuses on the interaction among Tfr, Tfh, and B cells, summarizes the characterization and function of Tfr cells, concludes the imbalance of CD4+T subsets in SLE, and presents potential therapies for SLE. In general, we discuss the roles of Tfr cells in the progress of SLE and provide potential treatments.…”
Get full text

Th2 cells and cytokine networks in allergic inflammation of the lung by Anthony J. Coyle, Shogo Tsuyuki

“…In view of the central role of this cytokine and the evidence that glucocorticoids are unable to modify many IL-4 dependent effects, Th2 inhibitors may prove to be novel therapies for the treatment of bronchial asthma.…”
Get full text

Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma by Hao Yu, Wenjing Liu, Kaikai Ding, Jiangjie Wu, Cheng Wang, Siyuan Wang, Lingyun Wu, Qiuying Tang, Xin Yin, Kan Jiang, Danfang Yan, Xu Wang, Si Chen, Senxiang Yan

“…Abstract Glioblastoma (GBM) remains a daunting oncological challenge because of its aggressive nature and resistance to conventional therapies. Inhibition of the intrinsic STING pathway in GBM hampers the effectiveness of immunotherapies. …”
Get full text