A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs by Min-Dian Li, Xiaoyong Yang

“…A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.…”
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Radioembolization in the Treatment of Neuroendocrine Tumor Metastases to the Liver by Martin Vyleta, Douglas Coldwell

“…On an outpatient basis, radioembolization can be utilized from early line to salvage phases, in various combinations with systemic therapies. Review of available data shows encouraging safety and efficacy profiles for the intraarterial application of 90Y for the treatment of mNETs of the liver. …”
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A Case Report with Severe Thrombocytopenia Induced by Axitinib by Ulkuhan I. Koksal, Janeiro Valle Goffin, Brian Lewis, Oliver A. Sartor, Elizaveta Belyaeva, Francisco Socola, Pedro C. Barata

“…In this report, we presented a rare case of grade 4 axitinib-induced thrombocytopenia, not observed with other antiangiogenic therapies. We discuss the differential diagnostic work-up, the necessary multidisciplinary approach, and the successful management of the case.…”
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Inflammatory bowel diseases during the COVID-19 pandemic by Edyta Derda, Edyta Szymańska, Magda Sokolek, Jarosław Kierkuś

“…Inflammatory bowel diseases (IBD) are chronic, incurable conditions of digestive system with unknown aetiology, but one of the causes is disordered immune response. Medical therapies most frequently used in IBD are immune suppressing or modifying with the rising use of biologic treatment. …”
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Progress on the Prevention of Esophageal Stricture after Endoscopic Submucosal Dissection by Peina Shi, Xiaoyun Ding

“…With the improvement of current therapies, ESD can be more widely utilized as a minimally invasive treatment with minimal complications.…”
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An induced pluripotent stem cell line, NIMHi014-A, generated from PBMCs of an epileptic patient harbouring a variant of the SCN1A gene by Madhura Milind Nimonkar, Gautham Arunachal, Ananthapadmanabha Kotambail, Ramya Sukrutha, Kenchaiah Raghavendra, Ghati K Chetan, Bhupesh Mehta, Yogananda S. Markandeya

“…This cell line will be used to study mechanism of epilepsy and develop patient specific therapies.…”
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Attitudes toward healthy nutrition in Germany — results from an online-representative cross-sectional survey by Etienne Hanslian, Etienne Hanslian, Julia Katharina Schiele, Julia Katharina Schiele, Michael Jeitler, Andreas Michalsen, Andreas Michalsen, Manfred Wischnewsky, Manfred Wischnewsky, Maximilian Andreas Storz, Benno Brinkhaus, Miriam Ortiz, Mike R. Sigl, Rasmus Hoffmann, Judith Lehmann, Daniela A. Koppold, Daniela A. Koppold, Daniela A. Koppold, Daniela A. Koppold, Christian S. Keßler, Christian S. Keßler

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Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1 by Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Anna Sancho-Balsells, Veronica Brito, Veronica Brito, Veronica Brito, Veronica Brito, Belissa Fernández, Belissa Fernández, Belissa Fernández, Belissa Fernández, Mónica Pardo, Mónica Pardo, Mónica Pardo, Mónica Pardo, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Marco Straccia, Silvia Ginés, Silvia Ginés, Silvia Ginés, Silvia Ginés, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Isabel Hernández, Belén Arranz, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Josep M. Canals, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt, Albert Giralt

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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

“…Conclusions These findings unify genome-wide screening approaches with the latest genetic and pharmacologic modeling methodologies to reveal an entirely novel epigenetic approach to individualize therapies against a challenging loss-of-function SETD2 mutation in cancer.…”
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Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Inhibiting katanin’s function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. Previous studies have shown that purine-based compounds exhibit a strong affinity for microtubule-severing enzymes. …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Despite knowledge of how circadian rhythms change in these grave conditions, very little research has been undertaken on the use of these therapies in support of sepsis management. This review details the circadian disruptions associated with sepsis and septic shock, the influence they have on morbidity and mortality, and the potential clinical benefits of circadian-modulating therapies.…”
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An overview of potential cardioprotective benefits of xanthophylls in atherosclerosis: an evidence-based review by Yuting Su, Feng Chen, Jiehua Chen, Mingfu Wang

“…Xanthophylls, one of the main groups of carotenoids, have been proposed as preventive agents or adjunct therapies to prevent and slow the progression of atherosclerosis due to their cardioprotective properties. …”
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STATE INSTITUTIONS IN THE FIGHT AGAINST THE NEGATIVE EFFECTS OF GAMBLING IN POLAND by Zygmunt DUDEK

“…It focuses on the Fiscal Administration, which controls this area of activity, and the National Health Fund, which, through financial outlays and therapies provided, helps the addicted to overcome their addiction to gambling. …”
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Tissue-Derived Stem and Progenitor Cells by Leora J. Tesche, David A. Gerber

“…Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.…”
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P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma by Sarah Bouri, Philippe Simon, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease.…”
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Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke by Aldo A. Mendez, Edgar A. Samaniego, Sunil A. Sheth, Sudeepta Dandapat, David M. Hasan, Kaustubh S. Limaye, Bradley J. Hindman, Colin P. Derdeyn, Santiago Ortega-Gutierrez

“…The paradigms on prehospital care, reperfusion therapies, and postreperfusion management of patients with AIS continue to evolve. …”
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Relapsed Mantle Cell Lymphoma Presenting as “Sister Mary Joseph Nodule” by Jennifer E. Vaughn, Ajay K. Gopal

“…This clinical course is characteristic of the mantle cell form of non-hodgkin's lymphoma and illustrates a need to seek out more effective therapies.…”
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Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration by Carlos Redondo-Gómez, Rocío Leandro-Mora, Daniela Blanch-Bermúdez, Christopher Espinoza-Araya, David Hidalgo-Barrantes, José Vega-Baudrit

“…CNTs still represent strong candidates for use in therapies of neurodegenerative pathologies and spinal cord injuries.…”
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REVIEW – DIGITAL TECHNOLOGIES IN DENTAL IMPLANT PLANNING by Chikh Al Sagha Sama, Cristea Ioana, Curelariu Nura, Agop-Forna Doriana, Davidescu Alexandra, Norina Forna

“…The success of implant therapies depends on the precision of implant placement to effectively support prosthetic outcomes that optimize form and function. …”
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Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis by Fabiana Furci, Marco Umberto Scaramozzino, Giuseppe Rocco Talesa, Corrado Pelaia

“…With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis.…”
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