A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease by Qingdong Guan

“…In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.…”
Get full text

Clostridium difficile – an Important Opportunistic Pathogen in Healthcare-Associated Infections by Soohyoun Ahn, Amarat H. Simonne

“… Opportunistic pathogens are significant health threats to vulnerable people with weakened immune systems, such as people with HIV/AIDS or those on immune-suppressing therapies. One opportunistic pathogen, Clostridium difficile, has been getting more attention in recent years because of its association with antibiotic use and high death rate in the elderly. …”
Get full text

Renal Cell Carcinoma with Synchronous Metastasis to the Calcaneus and Metachronous Metastases to the Ovary and Gallbladder by Jasper Decoene, Filip Ameye, Evelyne Lerut, Raymond Oyen, Hein Van Poppel, Steven Joniau

“…All metastases were surgically removed; no additional systemic therapies were used. Aggressive surgical treatment can prolong the survival of patients with resectable metastases. …”
Get full text

Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? by Thomas van den Bosch, Emine Kilic, Dion Paridaens, Annelies de Klein

“…Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies.…”
Get full text

Clostridium difficile – an Important Opportunistic Pathogen in Healthcare-Associated Infections by Soohyoun Ahn, Amarat H. Simonne

“… Opportunistic pathogens are significant health threats to vulnerable people with weakened immune systems, such as people with HIV/AIDS or those on immune-suppressing therapies. One opportunistic pathogen, Clostridium difficile, has been getting more attention in recent years because of its association with antibiotic use and high death rate in the elderly. …”
Get full text

Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review by Ayodele Atolagbe, Stanley Nkemjika, Olusegun Popoola, Oluwatoyin Oladeji, Irina Kogan, Haroon Saeed, Tolulope Olupona

“…Neutropenia is an adverse effect of various pharmacological therapies, including antipsychotics. Among the second-generation antipsychotic (SGA) medications, clozapine is most notable for neutropenic adverse effect. …”
Get full text

Management of Stable Angina with Ivabradine as Safe Alternative to Patients with Myasthenia Gravis by Giuliano Ohde Dalledone, Gustavo Lenci Marques, Renata Dal-Prá Ducci, Arnaldo Laffitte Stier Junior, Cláudia Suemi Kamoi Kay, Lineu Cesar Werneck, Paulo José Lorenzoni, Rosana Herminia Scola

“…A 48 y.o. woman, with MG diagnosis, presented stable angina. Therapies choices were reduced considering concomitant disease as well as previous and unsuccessful cardiologic managements. …”
Get full text

Gut microbiota on anxiety and depression in primary Sjogren's syndrome: A novel insight by Ying Zhu, Kaiyuan Zhang, Ziyue Luo, Yu Song, Xinchang Wang

“…It aims to provide novel therapies for these emotional disorders in pSS.…”
Get full text

Cardiovascular risk associated with glucagon-like peptide-1 receptor agonists versus other conventional glucose-lowering drugs in patients with type-2 diabetes: protocol for a nati... by François Schiele, Mikael Mazighi, Nicolas Danchin, Igor Sibon, Gilles Lemesle, Kamel Mohammedi, Laurent Fauchier, Bruno Detournay, Alexandre Caron, Corinne Emery, Camille Nevoret, Lucile Vigié, Christine Massien

“…Comparative analyses will be conducted versus these control groups, adjusting for cardiovascular event history and a propensity score considering age, sex, area of residence, deprivation index, comorbidities, duration of diabetes, use of lipid-lowering drugs, anticoagulants, antiplatelet therapies and blood pressure-lowering therapies. Comparative analyses will be conducted versus these control groups, using a high-dimensional propensity scores method and fixed baseline characteristics. …”
Get full text

Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs by Shami Chakrabarti, Mohammed Hoque, Nawshin Zara Jamil, Varan J. Singh, Daniel Pollacksmith, Neelab Meer, Mark T. Pezzano

“…In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable of forming functional thymic tissue will be critical in understanding thymic epithelial cell (TEC) ontogeny and designing strategies to reverse involution. …”
Get full text

Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro by Li B, Dong B, Xie L, Li Y

“…Additionally, we examine their specific mechanisms of action in animal models to provide new insights for developing safe and effective targeted therapies while guiding experimental and clinical applications against AR. …”
Get full text

The Role of Red Blood Cell Distribution Width in the Severity and Prognosis of Community-Acquired Pneumonia by Qiang Ren, Hebing Liu, Ying Wang, Deyu Dai, Zhennan Tian, Guiwei Jiao, Xiaomin Liu

Get full text

International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes by Wee Ling Heng, Helmi Albrecht, Paul Chiappini, Yeong Phang Lim, Linda Manning

Get full text

Comparing Cisplatin Dosing Schedules in Concurrent Chemoradiotherapy for Locally Advanced Head-and-Neck Cancer: A Comprehensive Review of Weekly Versus 3-Weekly Regimens by Oscar Chi-Yu Yang, Nai-Wen Su, Yi-Shing Leu, Yi-Fang Chang

“…Further randomized controlled trials are required to confirm the optimal cisplatin schedule and efficacy of combinational therapies with novel agents. These findings underline the importance of exploring treatment protocols that balance therapeutic benefits with reduced adverse effects and improved compliance.…”
Get full text

Combined Effects of Pericytes in the Tumor Microenvironment by Aline Lopes Ribeiro, Oswaldo Keith Okamoto

“…In this review, we highlight the contribution of pericytes to some classical hallmarks of cancer, namely, tumor angiogenesis, growth, metastasis, and evasion of immune destruction, and discuss how collectively these hallmarks could be tackled by therapies targeting pericytes, providing a rationale for cancer drugs aiming at the TME.…”
Get full text

Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure by Stefanie Gauguet, Kate Madden, Jennifer Wu, Christine Duncan, Gi Soo Lee, Tonya Miller, William C. Klingensmith, Sandra K. Burchett, Meredith van der Velden

“…Prompt initiation of adequate antifungal therapies is of utmost importance to improve outcome. …”
Get full text

Electric Field Analysis of Breast Tumor Cells by V. Gowri Sree, K. Udayakumar, R. Sundararajan

“…An attractive alternative treatment for malignant tumors that are refractive to conventional therapies, such as surgery, radiation, and chemotherapy, is electrical-pulse-mediated drug delivery. …”
Get full text

Fecal microbiota transplantation: lights and shadows of a new weapon against inflammatory bowel disease by Andrea Piccioni, Federico Rosa, Federica Manca, Davide Antonio Della Polla, Martina Petrucci, Benedetta Simeoni, Marcello Covino

“…In this article, we will discuss the strengths of this promising treatment, while also discussing the controversial aspects and concerns regarding one of the most innovative therapies of recent times.…”
Get full text

Secondary Immunodeficiency by Persia Pourshahnazari, Stephen D. Betschel, Vy. H. D. Kim, Susan Waserman, Rongbo Zhu, Harold Kim

“…The goal of this primer is to provide a general overview and understanding of common conditions and therapies leading to SID, as well as a guide to the assessment and management of patients with SID.…”
Get full text

Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer by Athanasia Pavlidou, Nikos F. Vlahos

“…Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer. This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. …”
Get full text