Managing Dyspnea in Patients with Advanced Chronic Obstructive Pulmonary Disease: A Canadian Thoracic Society Clinical Practice Guideline by Darcy D Marciniuk, Donna Goodridge, Paul Hernandez, Graeme Rocker, Meyer Balter, Pat Bailey, Gordon Ford, Jean Bourbeau, Denis E O’Donnell, Francois Maltais, Richard A Mularski, Andrew J Cave, Irvin Mayers, Vicki Kennedy, Thomas K Oliver, Candice Brown, Canadian Thoracic Society COPD Committee Dyspnea Expert Working Group

“…There are many questions concerning optimal management and, specifically, whether various therapies are effective in this setting. The present document was compiled to address these important clinical issues using an evidence-based systematic review process led by a representative interprofessional panel of experts.…”
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Arterial Stiffness in Chronic Kidney Disease: The Usefulness of a Marker of Vascular Damage by Antonio Bellasi, Emiliana Ferramosca, Carlo Ratti

“…In addition, this knowledge may help guide appropriate therapeutic choices and monitor the effectiveness of antihypertensive therapies. We review the relationship between arterial stiffness and CKD, as well as the prognostic implications of increased arterial stiffness and the potential therapeutic strategies to ameliorate arterial compliance and outcome in CKD.…”
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Ancillary Testing in Lung Cancer Diagnosis by William Dubinski, Natasha B. Leighl, Ming-Sound Tsao, David M. Hwang

“…With the emergence of new targeted therapies, the pathologist is called upon increasingly to provide not only accurate typing of lung cancers, but also to provide prognostic and predictive information, based on a growing number of ancillary tests, that may have significant impact on patient management. …”
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Endometrial Stem Cells and Reproduction by Sara S. Morelli, Pauline Yi, Laura T. Goldsmith

“…The development of novel therapies to treat infertility due to endometrial dysfunction requires an understanding of the latest advancements in endometrial cell biology, such as the role of endometrial stem cells. …”
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Efficacy and Safety of Paromomycin for Visceral Leishmaniasis: A Systematic Review by Pashupati Pokharel, Rakesh Ghimire, Pratik Lamichhane

“…Paromomycin, an aminoglycoside drug, is frequently used for the treatment of visceral leishmaniasis. Despite limited therapies for visceral leishmaniasis and emerging drug resistance, a proper review on the action of paromomycin for kala-azar is lacking. …”
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When Should the Treatment of Obesity in Thyroid Disease Begin? by Edyta Sutkowska, Michał Kisiel, Agnieszka Zubkiewicz-Kucharska

“…Thus, delaying the initiation of therapies beyond substitution treatment to achieve optimal weight reduction in individuals with thyroid dysfunction seems unwarranted. …”
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Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma by Sasikumar Jalajakumari Soumya, Kesavan Rathi Arya, Chandran Sheela Abhinand, Padmanabhan Sunitha, Ajitha Prabhakaran Athira, Achuthsankar Sukumaran Nair, Oommen V. Oommen, Perumana R. Sudhakaran

“…Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. …”
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Acquired Form of Angioedema of the Head and Neck Related to a Deficiency in C1-Inhibitor: A Case Report with a Review of the Literature by Bassel Hallak, Propser Konu, Florian Lang, Christian Simon, Philippe Monnier

“…Angioedema related to a deficiency in the C1-inhibitor protein is characterized by its lack of response to therapies including antihistamine, steroids, and epinephrine. …”
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Photopheresis Provides Significant Long-Lasting Benefit in Nephrogenic Systemic Fibrosis by Ranran Zhang, William Nicholas Rose

“…Manifestations include fibrosis of the skin and other tissues. Effective therapies are lacking. Photopheresis has been tried with variable rates of improvement, and small numbers of cases (20 as of 2016) have been reported of NSF patients treated with photopheresis. …”
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Role of Signaling Transduction Pathways in Development of Castration-Resistant Prostate Cancer by Takahiro Inoue, Osamu Ogawa

“…Great advances in our understanding of the biological and molecular mechanisms of prostate cancer progression have resulted in many clinical trials of numerous targeted therapies. In this paper, we review mechanisms of CRPC development, with particular focus on recent advances in the understanding of specific intracellular signaling pathways participating in the proliferation of CRPC cells.…”
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The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease by Chunxiang Ma, Reshma Vasu, Hu Zhang

“…A better understanding of the role of LCFAs in IBD will substitute or boost the current IBD therapies, thereby obtaining mucosal healing. In this review, we focused on the roles of LCFAs on the important links of inflammatory regulation in IBD, including in the pathogen recognition phase and in the inflammatory resolving phase, and the effects of LCFAs on immune cells in IBD.…”
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Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab by Dávid Csercsik, Levente Kovács

“…We validate the model against volume measurement data originating from experiments on mice and analyze the model behavior assuming different inputs corresponding to different therapies. Furthermore, we show that a simple extension of the model is capable of considering cytotoxic and antiangiogenic drugs as inputs simultaneously in qualitatively different ways.…”
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Endoscopic Removal of a Nitinol Mesh Stent from the Ureteropelvic Junction after 15 Years by Tomaž Smrkolj, Domagoj Šalinović

“…By combining minimally invasive urinary stone therapies—extracorporeal shock wave lithotripsy, semirigid ureterorenoscopy with laser lithotripsy, and percutaneous nephrolithotomy—it was possible to completely remove the encrusted stone and nitinol mesh stent that was implanted for 15 years, rendering the patient symptom and obstruction free.…”
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Stem Cells for Augmenting Tendon Repair by Lawrence V. Gulotta, Salma Chaudhury, Daniel Wiznia

“…Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions remain to be answered before stem cells can be used clinically. …”
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Ultra-rare Disease and Genomics-Driven Precision Medicine by Sangmoon Lee, Murim Choi

“…Indeed, several successful cases of molecular diagnosis and treatment with personalized or targeted therapies of rare genetic diseases have been reported. …”
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THE IMPLICATIONS OF SUGAMMADEX IN TEMPOROMANDIBULAR DISORDERS: A MULTIDISCIPLINARY APPROACH TO ORAL COMPLEX REHABILITATION IN ELDERLY PATIENTS-REWIEW part 1 by Lucian Stefan Burlea, Doriana Agop Forna, Liana Aminov, Tudor Hamburda, Maria Antonela Beldiman, Larisa Tarevici, Bogdan Petru Bulancea

“…The integration of sugammadex into multidisciplinary treatment protocols—including prosthetic rehabilitation, balneophysiotherapy, and pharmacological therapies—has the potential to improve outcomes significantly. …”
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The Endoscopic Management of Pain in Chronic Pancreatitis by Adam J. Goodman, Frank G. Gress

“…The effectiveness of these therapies is not only highly variable but also often controversial. …”
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The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma by Junying Lu, Lingxin Xiong, Xiaohao Zhang, Zhongmin Liu, Shiji Wang, Chao Zhang, Jingtong Zheng, Guoqiang Wang, Ruipeng Zheng, Jodie L. Simpson, Fang Wang

“…To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis.…”
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Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant by Giuseppe Bersani, Pietropaolo Marino, Giuseppe Valeriani, Valentina Cuoco, Claudia Zitelli, Claudia Melcore, Francesco Saverio Bersani

“…The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.…”
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Periodontal Regeneration Using Platelet-Derived Growth Factor in Infrabony Defects: A Series of Three Cases by Kaustubh Thakare, M. L. Bhongade, Preeti Charde, Priyanka Jaiswal, Nachiket Shah, Aniruddha Deshpande

“…The periodontal researchers and clinicians, in an effort to develop effective regenerative therapies, have sought to understand key events involved in the regeneration of periodontium. …”
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