Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decorticati... by Liz Darlison, John Edwards, Apostolos Nakas, Nick A Maskell, Wendy Underwood, Chris Rogers, Matthew Callister, David Waller, Richard Milton, Victoria Ashford-Turner, Paul Taylor, Claire Matthews, Victoria Hughes, Kelvin Lau, Alan Kirk, Robert C Rintoul, Elizabeth A Stokes, Kate Ashton, Daisy Elliott, Rosie Harris, Marie Kirwan, Juliette Novasio, Sara Waplington, Eric Lim, Holly Mckeon, Charlotte Jacobs, Laura White, Mary O’Brien, Judith Moore, Louise Li, Nicola Mills, Sanjay Popat, Suzanne Miller, Nadia Yousaf, D A Fennell, Clinton Ali, Andrea Bille, Liz Fuller, Andreea Ionescu, Manjusha Keni, Pek Koh, Talal Mansy, Dakshinamoorthy Muthukumar, Tony Pope, Amy Roy, Riyaz Shah, Jonathan Shamash, Zacharias Tasigiannopoulos, Sarah Treece, Katherine Joyce, Barbara Warnes, Athanasia Gravani, Rachel Brophy, Nicola Farrar, Jane Elliott, Philip Noyes, Louise Nelson, Sara Tenconi, Laura Socci, Hilary Wood, Helena Hanratty, Helena Stanley, Robert Rintoul, Amy Gladwell, Jenny Castedo, Amanda Stone, Charlotte Ingle, Hayley Hewer, Eleanor Aynsley, Andrea Watson, Alison Hassall, Masuma Begum, Christopher Worth, Ellie Piggott, Elizabeth Nadin, Yvonne Summers, Raffaele Califano, Laura Cove-Smith, Matt Evison, Maria Blinston, Amal Ismail, Rachel Chant, Asmita Desai, Ian Morgan, Victoria Lake, Nichola Harris, Simon Hodge, Nadza Tokaca, Adam Januszewski, Avani Athauda, Anisha Ramessur, Emily Grist, Niamh Colman, Michael Flynn, Joan Joyce, Sarah Vaughan, Maria Piga, Derya Sahin, Agnieszka Yongue, Emma Turay, Jaishree Bhosle, Rajiv Kumar, Charlotte Milner-Watts, Jessica Brown, David Walder, Alexandros Georgiou, Xiaorong Wu, Naila Kaudeer, Kroopa Joshi, Michael Davidson, Shelize Khakoo, Bee Ayite, Kathryn Priest, James Dobbyn, Vasanthi Prathapan, Deborah McCrimmon, Natalie Ash, Alison Norton, Bianca Peet, Libby Hennessy, Rosemary Johnson

“…Introduction Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. …”
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Differences in dialysis modality choice between immigrant and native populations in Barcelona, Spain by María Dolores Arenas-Jiménez, Jose Luis Fernandez-Martin, Isabel Galcerán Herrera, Marisol Fernández-Chamarro, Guillermo Pedreira-Robles, Silvia Collado Nieto, Julia Farrera Núñez, Eva Rodríguez García, Alicia Moreno Rodríguez, Laura Morro Fernández, Marta Crespo Barrio, Julio Pascual Santos

“…Keywords: advanced chronic kidney disease, socioeconomic status, demographic factors, shared decision making, renal replacement therapy, peritoneal dialysis, conservative care, hemodialysis, renal transplantation, language barrier, social determinants of health, immigration, social determinants of health. …”
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Combined pyrotinib and fulvestrant for hormone receptor‐positive and HER2‐positive metastatic breast cancer: A multicenter, single‐arm, phase II trial by Jianli Zhao, Yunfang Yu, Wei Ren, Linxiaoxiao Ding, Yongjian Chen, Peng Yuan, Jian Yue, Yaping Yang, Guorong Zou, Tao Chen, Jie Chai, Li Zhang, Wenjing Wu, Yinduo Zeng, Xiujuan Gui, Yangyang Cai, Simin Luo, Zhongyu Yuan, Kang Zhang, Herui Yao, Ying Wang

“…The median PFS was 18.2 months (95% CI, 11.9–31.1) overall, 19.5 months (95% CI, 10.6–NA) for those receiving the combination as first‐line therapy, and 18.4 months (95% CI, 16.7–NA) for patients with brain metastases. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…These emerging, widespread, and opportunistic pathogens have drawn significant attention due to their reduced susceptibility to commonly used antifungal agents, particularly azoles and polyenes, and, in some cases, therapy-induced resistance to echinocandins. Notably, C. auris is classified in the critical priority group on the World Health Organization's fungal priority pathogens list, which highlights fungal species capable of causing systemic infections with significant mortality and morbidity risks as well as the challenges posed by their MDR profiles, limited treatment and management options. …”
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Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial by Mohammad Jafar Eghbal, Ali Haeri, Arash Shahravan, Ali Kazemi, Fariborz Moazami, Mohammad Ali Mozayeni, Eshaghali Saberi, Mohammad Samiei, Mehdi Vatanpour, Alireza Akbarzade Baghban, Mahta Fazlyab, Ardavan Parhizkar, Mahboobe Ahmadi, Nazila Akbarian Rad, Shima Bijari, Delaram Bineshmarvasti, Paria Davoudi, Roya Dehghan, Mandana Dehghani, Habibollah Ebrahimi, Nafiseh Emami, Nafiseh Farajian, Rahim Fereidooni, Gelareh Ghobadi, Mostafa Ghodrati, Atefeh Gohari, Azadeh Hashemi, Mohammadreza Hosseini, Elham Karami, Nasir Kheirabadi, Sepideh Kozegari, Hadi Labaf Ghasemi, Alireza Majidi, Parastu Malekzadeh, Vahid Mehrabi, Mehrnush Mohammadi, Leila Moradi Eslami, Atefeh Noghani, Negin Omatali, Negar Pourhatami, Behnam Rahbani Nobar, Saeid Rahmani, Parviz Shafaq, Sara Soofiabadi, Somaye Teimoori, Farzaneh Vatandoost, Saeed Asgary

“…This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“… [12] Center for Drug Evaluation and Research. New drug therapy approvals 2020. U.S. Food and Drug Administration. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2020#first-in-class. …”
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Modeling the relationship between the moral charter derived from Islamic teachings and performance with the mediating variable of employees' perception by leila jahantigh, Abbas Babaeenezhad, Mohsen Zayandehroudi, saeed sayadi

“…More attention should be paid to work ethics in various dimensions of cognitive programs and organizational learning so as to increase the performance and active participation of employees in organizational affairs and to fulfill individual responsibilities; and the managers of universities and subordinate centers should pay serious attention to the various ethical dimensions of administrative therapy employees in order to increase the level of their employees' job performance and try to improve the moral level of employees by holding training workshops, forming problem solving teams and encouraging their employees.According to the results of the research, the following suggestions are presented:According to the Islamic teachings, the moral charter can become a program to transform the global threat into a global opportunity for the advancement of human culture and the excellence of human life. …”
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Estimation of tuberculosis incidence at subnational level using three methods to monitor progress towards ending TB in India, 2015–2020 by Swati Mahajan, Amar Shah, Sarit Sharma, Rituparna Das, Kathiresan Jeyashree, Mathavaswami Vijayageetha, Bhavesh Modi, Burugina Nagaraja Sharath, Vijay Singh, Shamim Mannan, Sairu Philip, Jasleen Kaur, Ranjani Ramachandran, Raghuram Rao, Sriram Selvaraju, Bency Joseph, Vaibhav Shah, Kiran Rade, Lalit Sankhe, Surinder Singh, Sandeep Chauhan, Anupam Banerjee, Devender Kumar, Ganapathy Kalaiselvan, Bhavin Vadera, Paras Mehta, Meenakumari Natarajan, Manoj Murhekar, Aswathy Sreedevi, Jeromie Thangaraj, Saravanakumar Velusamy, Sasidharan Akhil, Dhanapal Sudha Rani, Ramasamy Sabarinathan, Sakthivel Manikandanesan, Rajalakshmi Elumalai, Amarendra Mahapatra, Almas Shamim, Ashok Bhardwaj, Anil Purty, Anand Sridhar, Aniket Chowdhury, Asif Shafie, Avijit Choudhury, Deka Dhrubjyoti, Hardik Solanki, Krushna Sirmanwar, Kshitij Khaparde, Malik Parmar, Nisha Dahiya, Parija Debdutta, Quazi Ahmed, Ranjeet Prasad, Rohini Shinde, Rupali Baruah, Sandip Bharaswadkar, Shanta Achanta, Shibu Balakrishnan, Shivani Chandra, Sophia Khumukcham, Sudarsan Mandal, Sumitha Chalil, Venkatesh Roddawar, Kuldeep Sachdeva, Jayakrishna Kurada, Mayank Sharma, Debajyoti Mohapatra, Yogesh Patel, Sapna Thekkepat, Karthikeyan Kumaraswamy, Mallika Tharakan, Shramana Majumdar, Vrinda Manocha, Sukriti Chauhan, Shekhar Waikar, Puja Ambule, Krithika Murali, Devi Madhavi Bhimarasetty, Tulika Goswami, Darshan Mahyavanshi, Krutarth Bhrahmbhatt, Bhautik Modi, Anmol Gupta, Sunil Raina, Rajiv Kumar Gupta, Ratnesh Sinha, Manju Toppo, Gajen Medhi, Swati M Patki, Bishnu Ram Das, Lisa Sarangi, Afsal Hakim, Suresh Balan, Baer Philip Ravikumar, Subrata Baidya, Abhik Sinha, Boddepalli Nagendra Naidu, Bikash Chandra Nayak, Anoop Dev, Pallavi Boro, Debarshi Paul, Amrita Sarkar, Bhavesh Bariya, Jatin Chhaya, Dixit Chauhan, Mithun Sanghavi, Nilesh Thakor, Rohit Ram, Hinal Baria, Abhilash Sood, Anupam Parashar, Yangchen Dolma, Rakesh Bahl, Dilip Kumar, Mohammad Salim Khan, A K Jayasree, Zinia Nujum, Sheela P Haveri, Dinesh Bhatnagar, Subrata Kumar Palo, Priyesh Marskole, Prashant Verma, Dinesh Kumar Pal, Neelam Toppo, Sanjay R Quraishi, Sunil Panigrahi, Rambadan Chauhan, Jayashree Gothankar, Swapnali S Kadam, Dasi Rao, Sudhir Wanje, Pallavi Uplap, Ningombam Joenna Devi, Rikrak Ch Marak, Markordor Lyngdoh, Manoj B Patki, Satyajit Sundar Ray, Kavita Vasudevan, Mahesh Satija, Mahesh Choudhary, Mitin Parmar, Venkatesh Govindasamy, Karlapudi Nitesh Kumar, Goutham Thumari, Amar Tripura, Chanda Mog, Shampa Das, Ritesh Singh, Chandra Shekar Maity, Mamta Gehlawat

“…Sputum from participants with a history of anti-TB therapy (ATT), those currently experiencing chest symptoms or on ATT were tested using Xpert/Rif/TrueNat. …”
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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

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卒中恢复期患者心肺适能评估及中高强度有氧训练的可行性、安全性及有效性研究 Feasibility, Safety, and Efficacy of Cardiopulmonary Fitness Assessment and Moderate to High Intensity Aerobic Training for Patients Recovering... by 谢丽娜1，朱杰2，李琴英3，刘承弘3，邓盼墨3，贾杰2，3，4 (XIE Li’na1, ZHU Jie2, LI Qinying3, LIU Chenghong3, DEN Panmo3, JIA Jie2,3,4 )

“…Both groups received conventional rehabilitation therapy (3 hours/day, 5 days/week for 4 weeks). At the same time, the intervention group was added with the moderate to high intensity aerobic training (40 minutes/time, 5 times/week) according to the cardiopulmonary fitness results in accordance with the exercise prescription, and the control group was added with the rehabilitation guidance (rehabilitation education, flexibility training, etc.) for the same duration. …”
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Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium by Jessy Xinyi Han, Min Jung Koh, Leora Boussi, Mark Sorial, Sean M. McCabe, Luke Peng, Shambhavi Singh, Ijeoma Julie Eche-Ugwu, Judith Gabler, Maria J. Fernandez Turizo, Caroline T. MacVicar, Aditya Garg, Alexander Disciullo, Kusha Chopra, Alexandra Lenart, Emmanuel Nwodo, Jeffrey Barnes, Min Ji Koh, Eliana Miranda, Carlos Chiattone, Robert Stuver, Steven M. Horwitz, Mwanasha Merrill, Eric Jacobsen, Martina Manni, Monica Civallero, Tetiana Skrypets, Athina Lymboussaki, Massimo Federico, Yuri Kim, Jin Seok Kim, Jae Yong Cho, Thomas Eipe, Tanuja Shet, Epari Sridhar, Alok Shetty, Saswata Saha, Hasmukh Jain, Manju Sengar, Carrie Van Der Weyden, Henry Miles Prince, Ramzi Hamouche, Tinatin Murdashvili, Francine Foss, Marianna Gentilini, Beatrice Casadei, Pier Luigi Zinzani, Takeshi Okatani, Noriaki Yoshida, Sang Eun Yoon, Won-Seog Kim, Girisha Panchoo, Zainab Mohamed, Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al-Mansour, Josie Ford, Maria Elena Cabrera, Amy Ku, Govind Bhagat, Helen Ma, Ahmed Sawas, Khyati Maulik Kariya, Makoto Iwasaki, Forum Bhanushali, Owen A. O’Connor, Enrica Marchi, Changyu Shen, Devavrat Shah, Salvia Jain

“…Abstract: Variances in global access to drugs and treatment practices make it challenging to understand the benefit of contemporary therapies in patients with relapsed and refractory (R/R) mature T-cell and natural killer–cell lymphomas (MTCL and MNKCL). …”
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Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study by Patrice Cacoub, Arsène Mekinian, David Saadoun, Pavel I Novikov, Savino Sciascia, Corrado Campochiaro, Olivier Fain, Ilya Smitienko, Nicolas Schleinitz, Patrick Jégo, Francesco Muratore, Carlo Salvarani, Elena Galli, Sabine Berthier, Marc Lambert, François Maurier, Isabelle Kone-Paut, Sergey Moiseev, Masataka Kuwana, Alexandre Belot, Martin Michaud, Francis Gaches, Achille Aouba, Xavier Puechal, Karim Sacre, Tiphaine Goulenok, Alessandro Tomelleri, Thomas Sené, Elena Marina Baldissera, Luigi Boiardi, Abid Awisat, Ygal Benhamou, Vahan Mukuchyan, Mathieu Vautier, Azeddine Dellal, Lucie Biard, Julie Seguier, José Hernández-Rodríguez, Olivier Espitia, Sebastien Humbert, Guillaume Denis, Nolan Hassold, Dagna Lorenzo, Helene Munoz Pons, Jean Baptiste Gaultier, Le Mouel Edwige, Antoinette Perlat, Bertrand Lioger, Jonathan Broner, Virginie Dufrost, Faten Frikha, Alexandra Audemard-Verger, Pascal Woaye-Hune, Pierre Zeminsky, Moya Alvarado, Matheus Vieira, Alberto Lo Gullo

“…Objectives In this large multicentre study, we compared the effectiveness and safety of tocilizumab intravenous versus subcutaneous (SC) in 109 Takayasu arteritis (TAK) patients.Methods We conducted a retrospective multicentre study in referral centres from France, Italy, Spain, Armenia, Israel, Japan, Tunisia and Russia regarding biological-targeted therapies in TAK, since January 2017 to September 2019.Results A total of 109 TAK patients received at least 3 months tocilizumab therapy and were included in this study. …”
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Role of Pituitary Tumour Transforming Gene 1 in Medullary Thyroid Carcinoma by Maria Chiara Zatelli, Federico Tagliati, Vincenzo Amodio, Mattia Buratto, Mariarosa Pelizzo, Giancarlo Pansini, Marta Bondanelli, Maria Rosaria Ambrosio, Ettore C. degli Uberti

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An Assessment of Endoscopic and Concomitant Management of Acute Variceal Bleeding at a Tertiary Care Centre by H Singh, LE Targownik, G Ward, GY Minuk, CN Bernstein

“…BACKGROUND: Several therapies have been demonstrated to be beneficial in the management of acute variceal bleeding (AVB). …”
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Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma by Lawrence A. Shirley, Laura K. Aguilar, Estuardo Aguilar-Cordova, Mark Bloomston, Jon P. Walker

“…Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

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State-of-the-Art Management of Complications of Myeloma and Its Treatment by Monique A. Hartley-Brown, Daniel M. Sullivan, Rachid Baz

“…Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. …”
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Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response by Thomas Cochin, Sabine Noal, Dinu Stefan, Damien Bodet, Jérémie Rouger, Marine Dorbeau, Zoé Neviere

“…The treatment of this type of tumor includes systemic therapies such as chemotherapies or anti-inflammatories; in recent years, targeted anti-ALK therapies have emerged and became the standard of care in ALK rearranged patients. …”
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Refractory pityriasis rubra pilaris treated with abrocitinib by Filip Rob

“… Pityriasis rubra pilaris is a rare idiopathic papulosquamous disorder that significantly impacts the quality of life and is often refractory to conventional therapies. This study presents a case of successful treatment with an abrocitinib JAK1 inhibitor after several conventional and biologic therapies failed. …”
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