Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening by Yu-hong Wang, Ting-ting Liu, Yan-ping Guo, Shuo-ji Zhu, Zi-ming Liao, Jia-mei Song, Xi-ming Zhu, Jia-liang Liang, Moussa Ide Nasser, Nan-bo Liu, De-hua Chang, Ping Zhu, Bin Yao

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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Serum mepolizumab concentrations significantly increased at 6 and 12 months compared with those at 3 months, particularly in those with disease that responded to therapy. Furthermore, the relative change in mepolizumab concentration was significantly higher in those with response than in those with no response. …”
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Epidemiology, Controversies, and Dilemmas of Perioperative Nutritional Risk/Malnutrition: A Narrative Literature Review by He M, Long Y, Peng R, He P, Luo Y, Zhang Y, Wang W, Yu X, Deng L, Zhu Z

“…Current controversies and dilemmas in this field include the low rates of nutrition screening and medical nutrition therapy, numerous nutrition screening tools and malnutrition diagnostic criteria, no consensus on optimal assessment method, low level of evidence-based clinical nutrition research and lack of in-depth mechanistic studies, inconsistent timing of nutrition assessment, lack of reports for community hospitals, small hospitals, and low/middle-income countries or regions, and under-recognition of micronutrient malnutrition. …”
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Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

“…The aim of the pilot study is to assess feasibility of the main trial and inform implementation of screening and trial procedures.Methods and analysis SAFER is planned to be a pragmatic randomised controlled trial (RCT) of over 100 000 participants aged 70 years and over, not on long-term anticoagulation therapy at baseline, with an average follow-up of 5 years. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Altogether, our findings provide a potential avenue for angiotargeted therapies to prevent hepatic melanoma metastasis.…”
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Clinical effect of auricular point pressing with beans combined with acupoint massage in the treatment of post-stroke constipation with Qi deficiency syndrome (耳穴压豆联合穴位按摩治疗中风后气虚便秘的... by LI Chenchen (李陈晨), YANG Yu (杨宇), FAN Yan (范艳), JIA Tieying (贾铁英), HU Shirong (胡世荣)

“…Conclusion Auricular point pressing with beans combined with acupoint massage therapy is effective to improve the clinical symptoms of patients with post-stroke constipation of Qi deficiency syndrome. …”
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Renal dysfunction contributes to deteriorated survival outcomes in patients with upper and lower gastrointestinal bleeding: insights from a cohort study of 1160 cases by Orsolya Anna Simon, Levente Frim, Nelli Farkas, Zoltán Sipos, Nóra Vörhendi, Eszter Boros, Dániel Pálinkás, Brigitta Teutsch, Patrícia Kalló, Vivien Vass, Andrea Szentesi, Roland Hágendorn, Péter Hegyi, Bálint Erőss, Imre Szabó

“…Numerous primary (in-hospital mortality, discharge, need for endoscopic intervention, in-hospital rebleeding, length of hospitalisation, need for emergency surgery, need for endoscopic examination and need for intensive care unit) and secondary (detection of Helicobacter pylori (H. pylori), recognition of cancer as the source of bleeding, need for any kind of transfusion or clotting factor, anticoagulation therapy) outcomes were observed. Descriptive statistical tools were used to summarize our data. …”
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Cardiac computed tomography‐derived myocardial tissue characterization after anthracycline treatment by Koichi Egashira, Daisuke Sueta, Masafumi Kidoh, Mai Tomiguchi, Seitaro Oda, Hiroki Usuku, Kaori Hidaka, Lisa Goto‐Yamaguchi, Aiko Sueta, Takashi Komorita, Fumi Oike, Koichiro Fujisue, Eiichiro Yamamoto, Shinsuke Hanatani, Seiji Takashio, Satoshi Araki, Kenichi Matsushita, Yutaka Yamamoto, Toshinori Hirai, Kenichi Tsujita

“…Methods and results We prospectively investigated 15 consecutive breast cancer patients who were scheduled to receive anthracycline therapy. We performed echocardiography and CCT before and 3, 6, and 12 months after anthracycline treatment. …”
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Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus by Myrofora Goutaki, Yin Ting Lam, Andreas Anagiotos, Miguel Armengot, Andrea Burgess, Raewyn Campbell, Mathilde Carlier, Nathalie Caversaccio, Neil K. Chadha, Berat Demir, Sinan Ahmed D. Dheyauldeen, Onder Gunaydin, Amanda Harris, Isolde Hayn, Deniz Inal-Ince, Eric Levi, Trini Lopez Fernandez, Jane S. Lucas, Bernard Maitre, Anne-Lise M.L. Poirrier, Lynne Schofield, Kazuhiko Takeuchi, Christine van Gogh, Nikolaus E. Wolter, Jean-François Papon

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The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby cou... by Wenxin Zhang, Wenxin Zhang, Hongbo Teng, Hongbo Teng, Tianyi Zhao, Tianyi Zhao, Roberts I. Eglitis, Xv Wang, Xv Wang, Zhengxuan Yu, Shurong Qu, Shurong Qu, Haijing Wang, Haijing Wang, Yaru Zhao, Yaru Zhao, Bowen Fan, Bowen Fan, Shuangli Liu, Shuangli Liu, Yan Zhao, Yan Zhao

“…Nevertheless, side effects such as cisplatin-induced ototoxicity (CIO) pose obstacles to tumor therapy.The important natural product chiisanoside from Acanthopanax sessiliflorus has abundant activity against CIO.MethodsIn this study, 26 chiisanoside derivatives were screened, and compound 19 demonstrated significant protective activity against CIO damage. …”
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Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing by Fuqiang Song, Anqi Ye, Linyuan Jiang, Yang Lu, Yanzhen Feng, Rong Huang, Siting Du, Xiaoyu Dong, Ting Huang, Ping Li, Liangliang Yang, Jinjing Zhang, Mengjia Xu, Li Cheng, Jian Xiao

“…Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@PDA) on reduced graphene oxide (rGO) with photothermal therapy (PTT) and silver nanoclusters (AgNCs) for synergistic antibacterial treatment. …”
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Diabetes Mellitus, Extreme Insulin Resistance, and Hypothalamic-Pituitary Langerhans Cells Histiocytosis by Mathilde Sollier, Marine Halbron, Jean Donadieu, Ahmed Idbaih, Fleur Cohen Aubart, Corinne Vigouroux, Martine Auclair, Olivier Bourron, Marie Bastin, Géraldine Béra, Philippe Touraine, Jacques Young, Héléna Mosbah, Agnès Hartemann, Fabrizio Andreelli, Chloé Amouyal

“…Association of vinblastine and purinethol was started followed by a second-line therapy by cladribine. During the follow-up, the patient was admitted for recurrence of hyperglycemic states and extreme insulin resistance. …”
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Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients wi... by Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Daisuke Chujo, Jianhui Liu, Yuuki Shima, Azusa Ohbatake, Yukiko Miyamoto, Satoko Okazaki, Naoko Ito, Kaoru Nakano, Masataka Shikata, Asako Enkaku, Akiko Takikawa, Hisae Honoki, Shiho Fujisaka, Hideki Origasa, Kazuyuki Tobe

“…The aim was to investigate (1) whether liraglutide therapy could improve B-type natriuretic peptide (BNP) levels and diastolic cardiac function assessed by the E-wave to E′ ratio (E/E′) using transthoracic echocardiography (TTE), and (2) whether E/E′ contributed to BNP improvement independent of bodyweight reduction (UMIN000005565). …”
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Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

“…Background: The combination of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard of care for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (aBC). …”
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Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project by Michael Taylor, Vasileios Panoulas, Jill Smith, Alex Rosenberg, Mark Mason, Ian McGovern, Majid Akhtar, Sachin Mehta, Waqas Akhtar, Anthony McKay, Sumesh Thiruthalil, Orinta Kviatkovske, Donna Hall, Eftychia Galiatsou, Sofia Pinto, Maria Comanici, Emanuele Gerlando, Timothy Pitt, Joe Hughes, Olaf Maunz, Elia Keating, Julia Gangata, Eleanor Ross, Sophie Avetoom, Jane Durrant, Ciara Collins, Anand Jothidasan, Maria Monteagudo-Vela, Jerry Mitchell, Hatem Soliman Aboumarie, Caroline Bullen, Sundeep Kaul, Clara Hernandez Caballero, Ana Hurtado, Nick Lees

“…Background Survival for cardiac arrest remains poor, and the use of extracorporeal cardiopulmonary resuscitation (ECPR) has been suggested as a potential therapy to improve outcomes. Harefield Hospital has been performing ECPR for over a decade; however outcomes have been historically poor.Methods A retrospective analysis was performed of all ECPR cases at Harefield Hospital between April 2018 and April 2023. …”
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Acupoint application of Xiefu prescription in the prevention of functional constipation in long-term bedridden patients with pelvic fracture (泻腑贴方穴位贴敷预防长期卧床骨盆骨折患者功能性便秘的临床研究)... by GU Tianjiao (顾天姣), LIU Yingchun (刘迎春), DONG Ziqing (董子青), DING Di (丁娣), DENG Lixia (邓丽霞), YANG Yanhui (杨燕辉), MAO Lingling (毛玲玲)

“…Conclusion Acupoint application of Xiefu prescription and sticking therapy has a good preventive effect on functional constipation in long-term bedridden patients with pelvic fracture. …”
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Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis by Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U. Joseph Schoepf, Jian Li, Yining Wang

“…Moreover, myocardial edema assessment identified patients in need of adjunctive therapies, which is of particular prognostic significance in patients with deep therapeutic response.…”
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Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Ultimately, it will pave the way for low-threshold prevention, clinical treatment, and therapy to target diverse contexts of everyday life in SUD. …”
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Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…Additionally, artificial intelligence (AI) and machine learning are increasingly applied in MRSA diagnosis and treatment, and phage therapy and vaccine development have become future research hotspots.ConclusionMethicillin-resistant Staphylococcus aureus BSIs remain a major global public health challenge, especially with the increasing severity of antibiotic resistance. …”
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HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in... by Augustine T Choko, Elizabeth L Corbett, Nigel Stallard, Hendramoorthy Maheswaran, Aurelia Lepine, Cheryl C Johnson, Doreen Sakala, Thokozani Kalua, Moses Kumwenda, Richard Hayes, Katherine Fielding

“…The primary outcome was the proportion of male partners who were reported to have tested for HIV and linked into care or prevention within 28 days, with referral for antiretroviral therapy (ART) or circumcision accordingly. Women were interviewed at 28 days about partner testing and adverse events. …”
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