Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients by Toshiaki Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Sho Takeda, Hibiki Umeda, Kazuya Moriwake, Masashi Kayano, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuhiro Yoshida, Yuki Matsumi, Hiroyuki Michiue, Hideki Yamamoto, Hiroyuki Kishimoto, Fuminori Teraishi, Ryohei Shoji, Nobuhiko Kanaya, Hajime Kashima, Yoshihiko Kakiuchi, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

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Analyzing practice pattern in treating partial-thickness rotator cuff tears: a dual perspective from national database and American Shoulder and Elbow Surgeons PARCIAL research gro... by H. Mike Kim, MD, Emily Leary, PhD, Champ L. Baker, 3rd, MD, Leslie A. Barnes, MD, R. Alexander Creighton, MD, Frances Cuomo, MD, Matthew J. DiPaola, MD, Abdullah Foad, MD, James M. Gregory, MD, Brian F. Grogan, MD, Scott G. Kaar, MD, MBA, Eitan M. Kohan, MD, Sumant G. Krishnan, MD, Eddie Y. Lo, MD, John T. Moor, MD, Michael Nguyen, BS, Monica DiFiori, MD, Gabriel Masters, BA, Te Feng Arthur Chou, MD, Riccardo Raganato, MD, Lucas P. Bowen, BS, Jordan J. Harmon, BS, Tessa C. Griffin, BS, Alec E. Winzenried, MD, Evan M. Polce, BS, Cory J. Call, BS, Benjamin Nwadike, MD, Alvin Ouseph, MS, Monia Nazemi, MS, Kyle McCall, BA

“…The retrospective chart review of the ASES research group revealed that PTRCT repairs constituted 27.8% of all rotator cuff repairs with substantial variability among institutions (8.6%-67.1%), that nonoperative measures were commonly employed, with a mean 12-month duration before surgical repair, and that the most common type of nonoperative treatment was supervised physical therapy combined with corticosteroid injection (37.7%). …”
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Effect of Traditional Chinese Medicine comprehensive nursing interventions on prevention of abdominal distension and constipation after unilateral total knee replacement (中医综合护理预防单... by ZHANG Pan (张盼), KONG Hua (孔华), XING Liang (邢亮)

“…In the observation group(n=60), comprehensive nursing interventions including Chinese medicine hot election bag, constipation massage therapy combined with acupoint application were carried out. …”
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Effect of Traditional Chinese Medicine enema combined with injection via gastric tube in the treatment of gastrointestinal dysfunction in ICU patients (中药胃肠联合治疗ICU患者胃肠功能障碍的效果观察)... by ZHONG Yongjian (钟永建)

“…All patients received anti-infection, multiple organ support therapy, nasogastric tube placement and critical care nursing. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…It may serve as an adjunctive treatment for GD alongside traditional therapies such as antithyroid medications, surgery, and radioiodine therapy.…”
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Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers by Lothar Häberle, Ramona Erber, Paul Gass, Alexander Hein, Melitta Niklos, Bernhard Volz, Carolin C. Hack, Rüdiger Schulz-Wendtland, Hanna Huebner, Chloë Goossens, Matthias Christgen, Thilo Dörk, Tjoung-Won Park-Simon, Andreas Schneeweiss, Michael Untch, Valentina Nekljudova, Sibylle Loibl, Arndt Hartmann, Matthias W. Beckmann, Peter A. Fasching

“…Conclusions A pCR prediction model for neoadjuvant therapy decision-making was established. Combining pCR and recurrence prediction allows identification of not only patients who benefit most from neoadjuvant chemotherapy, but also patients with a very unfavorable prognosis for whom alternative treatment strategies should be considered.…”
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Analysis of Genetic Variation in CD40 and CD40L: Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome by D. E. Martínez-Fernández, J. R. Padilla-Gutiérrez, F. Casillas-Muñoz, Emmanuel Valdés-Alvarado, Brenda Parra-Reyna, Maricela Aceves-Ramírez, J. F. Muñoz-Valle, U. Zalapa Flores, J. C. Chávez Herrera, Y. Valle

“…However, they could reflect the inflammatory process and platelet activation in ACS patients, even when they are under pharmacological therapy. Due to the important roles of the CD40-CD40L system in the pathogenesis of ACS, longitudinal studies are required to determine if soluble levels of CD40 and CD40L could be clinically useful markers of a recurrent cardiovascular event after an ACS.…”
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Dynamics of HDL-Cholesterol Following a Post-Myocardial Infarction Cardiac Rehabilitation Program by Carlos Bertolín-Boronat, Héctor Merenciano-González, Víctor Marcos-Garcés, María Luz Martínez-Mas, Josefa Inés Climent Alberola, Nerea Pérez, Laura López-Bueno, María Concepción Esteban-Argente, María Valls Reig, Ana Arizón Benito, Alfonso Payá Rubio, César Ríos-Navarro, Elena de Dios, Jose Gavara, Juan Sanchis, Vicente Bodi

“…Data was collected on clinical variables, cardiovascular risk factors, treatment goals, pharmacological therapy, and health outcomes through questionnaires at the beginning and at the end of Phase 2 CRP. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation Combined with Voice Training on Voice Function of Patients with Parkinson's Disease by WANG Xiaowen, ZHU Qingqing, CHEN Yan, QIAN Hong, YUAN Haixin, ZHAO Gang, LIU Jie, ZHANG Fengjiao

“…The control group were treated with routine anti PD drugs and routine voice training, including abdominal breathing training, respiratory and vocal coordination training, breathing support ability training, voice real-time stress therapy, tonal training,vocal cord relaxation training, tone quality training,resonance relaxation training, etc.The training time was 40 minutes a time, once a day, continuous training for 30 days.The observation group received high-frequency rTMS stimulation on the basis of the control group. …”
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Effect of Traditional Chinese Medicine fumigation combined with acupoint massage in the prevention of deep venous thrombosis of lower limbs in elderly hospitalized patients in the... by DONG Fangfang (董芳芳), ZHANG Linying (张林英), HE Yan (贺艳), XU Man (许曼), LIU Zijing (刘紫荆), XIONG Qiuwan (熊秋婉)

“…Conclusion Through improving lower limb blood flow and reducing blood hypercoagulability and D-dimer level, Traditional Chinese medicine fumigation therapy combined with acupoint massage is potentially effective in the prevention of lower limb venous thrombosis in elderly patients. …”
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Recurrent adenoid cystic carcinoma of the left upper palate accompanied by massive maxillary hemorrhage: a case report and literature review by ZHANG Wangru, CHEN Yuanyuan, LI Zhiping, MENG Jian

“…An individualized treatment plan was developed under MDT, incorporating postoperative radiotherapy, targeted therapies, and immunotherapy to manage the tumor. Results Through the MDT model, the patient successfully achieved emergency hemostasis, and normal vital signs were restored. …”
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Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect by Yunfei Zuo, Pei Li, Wen‐Jin Wang, Changhuo Xu, Shuting Xu, Herman H. Y. Sung, Jianwei Sun, Guorui Jin, Weiping Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang

“…While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ‐H2 is designed that can realize robust theranostic effects both in vitro and in vivo. …”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Although antiretroviral therapy (ART) has improved KS control in people with HIV (PWH), treatment options for advanced KS remain limited. …”
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Diagnostics and treatment of gastroesophageal reflux disease: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, I. . A.s. Trukhmanov, Ye. K. Baranskaya, O. B. Dronova, O. V. Zayratyants, R. G. Sayfutdinov, A. A. Sheptulin, T. L. Lapina, S. S. Pirogov, Yu. A. Kucheryavy, O. A. Storonova, D. N. Andreyev

“…PPIs are applied for the long­term baseline treatment (no less than 4-8 wks) and maintenance therapy (6-12 months). Intake of alginates is pathogenically reasonable therapeutic approach for reduction of «acid pocket» and acid neutralization in the area of gastro­esophageal junction in GERD patients by formation of mechanical barrier raft which prevents reflux of the stomach content into the esophagus. …”
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Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis by Tomonori Oka, Tatsuya Hasegawa, Truelian Lee, Valeria S. Oliver-Garcia, Mahsa Mortaja, Marjan Azin, Satoshi Horiba, Sabrina S. Smith, Sara Khattab, Kathryn E. Trerice, Steven T. Chen, Yevgeniy R. Semenov, Shadmehr Demehri

“…Interestingly, immune checkpoint blockade therapy was associated with decreased epidermal LC–T cell contact in the normal skin of patients with cancer affected by cutaneous immune-related adverse events. …”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…In a data set generated from BC patients refractory to conventional therapy we showed that ESR1 mutations are correlated in advanced diseases with downregulation of molecules involved in antigen presentation and with loss HLA Class I gene expression. …”
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Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

“…BackgroundCFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF). …”
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Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II by Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

“…Our results pave the way to apoV‐based therapy for NAFLD.…”
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Therapeutic Effect of <italic>Self-made Wrist Joint Flexion and Extension Orthoses</italic> Combined with Routine Rehabilitation Training on Wrist Joint Spasm after Brain Infarctio... by Rui JIAO, Shangjie CHEN, Shuqian LI, Xinyan JIA, Heng LIU

“…Routine rehabilitation group was given convulsive electrical stimulation, electromyographic biofeedback, electronic biofeedback, job training, hand function training, exercise therapy, ordinary acupuncture and so on. The flexion and extension orthoses group was trained with flexion and extension device on the basis of routine rehabilitation treatment. …”
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Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7 by Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu

“…Therefore, LMW-HA may contribute to the development of PTC via TLR4/CXCR7 pathway, which may be a novel target for PTC immunomodulatory therapy.…”
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