Role of 3-mercaptopyruvate sulfurtransferase in cancer: Molecular mechanisms and therapeutic perspectives by Ka Zhang, Yi-Wen Zhu, Ao-Qi Tang, Ze-Tao Zhou, Yi-Lun Yang, Zi-Hui Liu, Yan Li, Xiao-Yi Liang, Zhi-Fen Feng, Jun Wang, Tong Jiang, Qi-Ying Jiang, Dong-Dong Wu

“…The impact of 3-MST inhibition on the development of tumors and its potential for tumor therapy are also highlighted.…”
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Fibrinogen-albumin ratio predicts treatment response in phospholipase A2 receptor-associated membranous nephropathy with nephrotic syndrome by Suyan Duan, Si Chen, Chen Chen, Fang Lu, Ying Pan, Yifei Lu, Qing Li, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Yanggang Yuan

“…Therefore, this study aims to clarify the association between FAR and disease activity and therapy response of PMN.Methods 110 biopsy-proven phospholipase A2 receptor (PLA2R) -associated PMN participants with nephrotic syndrome from January 2017 to December 2021 were recruited in the First Affiliated Hospital of Nanjing Medical University. …”
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3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

“…Eventually, our findings demonstrate that this system effectively forms orthotopic implantation of hepatorganoids and facilitates vascularization, which may notably contribute to the understanding of transplantation, drug screening, and replacement therapy.…”
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Impact of antiviral prophylaxis on EBV viremia and posttransplant lymphoproliferative disorders in solid organ transplant recipients: a systematic review and meta-analysis by Marjan Moghadamnia, Khadijeh Delroba, Shima Heidari, Zahra Rezaie, Simin Dashti-Khavidaki

“…Key Summary Points Post-transplant lymphoproliferative disorders (PTLD) and other EBV syndromes are among the most serious complications following solid organ transplantation (SOT), primarily due to the necessity for prolonged immunosuppressive therapy. Among the strategies for preventing EBV-related complications, the use of antiviral prophylaxis is a subject of ongoing debate. …”
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High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with 18F-DCFPyL by Rudolf A. Werner, Bilêl Habacha, Susanne Lütje, Lena Bundschuh, Takahiro Higuchi, Philipp Hartrampf, Sebastian E. Serfling, Thorsten Derlin, Constantin Lapa, Andreas K. Buck, Markus Essler, Kenneth J. Pienta, Mario A. Eisenberger, Mark C. Markowski, Laura Shinehouse, Rehab AbdAllah, Ali Salavati, Martin A. Lodge, Martin G. Pomper, Michael A. Gorin, Ralph A. Bundschuh, Steven P. Rowe

“…In patients with prostate cancer (PC) receiving prostate-specific membrane antigen- (PSMA-) targeted radioligand therapy (RLT), higher baseline standardized uptake values (SUVs) are linked to improved outcome. …”
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Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia by Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu

“…IntroductionAntiretroviral therapy (ART) increases the life expectancy of persons living with HIV (PLWH), but not without potentially serious adverse effects. …”
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A meta-analysis of randomized controlled trials: evaluating the efficacy of isokinetic muscle strengthening training in improving knee osteoarthritis outcomes by Wanqin Guo, Jingyang Gao, Dawazhuoma, Xiuling Mi, Ciwang, Bianba

“…IMST significantly improved physical therapy outcomes, including knee Flex PT and knee Ext PT at an angular velocity of 60°/second (standardized mean difference 13.19 [95% confidence interval 6.44, 19.94], P = 0.0001 and 16.34 [11.47, 21.22], P < 0.00001, respectively), and 180°/second (11.17 [2.86, 19.48], P = 0.008 and 12.62 [3.49, 21.75], P = 0.0077, respectively); knee Flex TW (79.77 [49.43, 110.10], P < 0.0001), Ext TW (86.27 [58.40, 114.15], P < 0.00001), knee Flex MRTW (9.38 [3.20, 15.56], P = 0.003), knee Ext MRTW (15.52 [8.96, 22.08], P < 0.0001), knee Flex AP (8.66 [0.70, 16.61], P = 0.03), knee Ext AP (7.27 [3.30, 11.23], P = 0.0003), knee Flex ROM (10.62 [7.94, 13.30], P < 0.00001), and LKSS scores (7.90 [5.91, 9.89], P < 0.00001). …”
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THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…In case of detection of clinically insignificant PC assistance was provided at the level of ITC (active surveillance, watchful waiting, hormone therapy on the recommendations of the oncourologist of regional urology center).Results. …”
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<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…In summary, CIO exerted promising antidepressant effects in behavioral despair and antianxiety and antidepressant effects in CUMS-induced depressive mice. Moreover, CIO therapy was facilitated by increasing the 5-HT content, alleviating the damage of hippocampal neurons, and upregulating the BDNF/ERK and PI3K/AKT/mTOR cascade. …”
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The use of antimicrobials in Italian buffalo farms by Gabriele Di Vuolo, Federico Scali, Claudia Romeo, Valentina Lorenzi, Chiara D. Ambra, Maria Serrapica, Giovanna Cappelli, Francesca Fusi, Esterina De Carlo, Giovanni Loris Alborali, Luigi Bertocchi, Domenico Vecchio

“…The three most common causes of AMU in adult buffaloes were: urogenital (39.2%), dry cow therapy (26.2%), and mastitis (22.8%). The main molecules used are represented by tetracyclines followed by III- IV generation cephalosporins (III-IVGenCep) and I-II generation cephalosporins. …”
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The first experience with brolucizumab for neovascular age-related macular degeneration by A.N. Kulikov, D.S. Maltsev, A.Yu. Malafeeva, S.M. Perminova, V.R. Zhalimova, A.S. Vasiliev, A.A. Kazak

“…</i> </p> <p> <i><b>Keywords</b>: age-related macular degeneration, brolucizumab, optical coherence tomography, anti-VEGF therapy.</i> </p> <p> <i><b>For citation:</b> Kulikov A.N., Maltsev D.S., Malafeeva A.Yu. et al. …”
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Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Exclusion criteria: patients using other types of therapy prior to biochemical recurrence. Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
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Examining the effect of direct-from-blood bacterial testing on antibiotic administration and clinical outcomes: a protocol and statistical analysis plan for a pragmatic randomised... by Li Wang, Wesley H Self, Todd W Rice, Matthew W Semler, Karen F Miller, Cheryl L Gatto, Andrea Fletcher, Romney M Humphries, Joanna L Stollings, Adrienne Baughman, Jakea Johnson, Edward T Qian, Mary Lynn Dear, David C Gaston, Ariel A Lewis, George E Nelson, Benjamin J Ereshefsky, Matthew A Christensen, Ritu Banerjee, Dan Albert, Alison Benton, Laura Bobbitt, Carleigh Burns, Timothy Duff, David C. Gaston, MLS Sharon Glover, Allyson Hobbie, Austin Ing, Gabriel Kemp, Sheryl Mangrum, Geoff Mavrak, Kelly Moser, David Mulherin, Shannon Pugh, Matthew Rodgers, Chrissie Schaeffer, Adam Turner, Sabrina Shipman, Halden Z VanCleave, Hamilton Wen Li Wang, LaKeysha Wiggins

“…Additional outcomes include highest stage of acute kidney injury, lowest platelet count and receipt of kidney replacement therapy within 14 days of randomisation, as well as hospital-free days, intensive care unit-free-days and all-cause, in-hospital mortality within 28 days of randomisation. …”
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The sense of safety theoretical framework: a trauma-informed and healing-oriented approach for whole person care by Johanna M. Lynch, Kurt C. Stange, Christopher Dowrick, Linn Getz, Pamela J. Meredith, Mieke L. Van Driel, Meredith G. Harris, Meredith G. Harris, Kate Tillack, Caley Tapp, Caley Tapp

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Validation of ACC/AHA and ESC Sudden Cardiac Death Risk Guidelines in Diverse Hypertrophic Cardiomyopathy Cohort: Stratification HCM Study by Murillo Oliveira Antunes, Fabio Fernandes, Edmundo Arteaga-Fernandez, Félix José Alvarez Ramires, Vinicius Machado Correia, Juliano Novaes Cardoso, Cristhian Espinoza Romero, Henrique Martins Sousa, Marília Taily Soliani, Matheus Ramos Ramos Dal Piaz, Anna Danielle Rodrigues Gandarella, Ruiza Gonçalves Rocha Teixeira, Charles Mady, Caio Assis Moura Tavares, Patricia O. Guimarães, Vagner Madrini Junior

“…The primary outcome was SCD, aborted cardiac arrest due to ventricular fibrillation (VF), sustained ventricular tachycardia (SVT), episode of VF or SVT, or appropriate ICD therapy. Risk prediction models were assessed using the C-index. …”
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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…Conclusions: The presence of L. pneumophila strains with reduced susceptibility or resistance to azithromycin should be monitored to predict future trends and suggest to physicians a combined therapy with fluoroquinolones when a poor response to azithromycin is observed. © 2025 The Author(s). …”
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A study of relationship between cardiac exposure dose-volume and cardiovascular autonomic dysfunction in radiotherapy by CHEN Hongyu, SU Pengyu, LUO Wenzi, PANG Dequan, WANG Feiran

“…Inclusion criteria: ① Patients who were pathologically confirmed to have malignant tumors (lung cancer breast cancer or esophageal cancer); ② patients with radiation therapy indications as recommended by the guidelines; ③ patients with an ECOG score of 0-1; ④ patients with no significant abnormalities in electrocardiogram and echocardiography results. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Developing targeted assays and treatments for INPP4B could facilitate early identification of patients likely to exhibit resistance to gemcitabine therapy, thereby improving their prognosis.…”
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Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials by Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Yi-Fei Wang, Yi-Fei Wang, Yi-Fei Wang, Zhen-Chao Niu, Zhen-Chao Niu, Yu-Fei Li, Hui-Min Zheng, Hui-Min Zheng, Jia-Ming Huan, Jie Yuan, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Yun-Lun Li, Yun-Lun Li, Yun-Lun Li

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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…Scalable solutions like self-administered topical therapies can help close this gap. In a recent Phase I trial (ClinicalTrials.gov NCT05362955), we demonstrated safety and adherence to self-administered intravaginal 5% 5-Fluorouracil (5FU) cream as an adjuvant therapy for cervical precancer among women living with HIV (WLWH) in rural Kenya. …”
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