Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…Natural killer (NK) cells emerged as a promising effector population that can be harnessed for anti-tumor therapy. In this work, we constructed NK cell engagers (NKCEs) based on NKp30-targeting single domain antibodies (sdAbs) that redirect the cytotoxic potential of NK cells toward epidermal growth factor receptor (EGFR)-expressing tumor cells. …”
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CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability by Dandan Zhang, Ming Jiang, Pan Li, Kyle Vaughn Laster, Dengyun Zhao, Yafei Zhi, Huifang Wei, Wenna Nie, Yunfeng Gao, Qiong Wu, Pu Xiang, Xinyu He, Kangdong Liu, Zigang Dong

“…Thus, our work identifies that KAT8 could serve as a potential clinically relevant biomarker and therapeutic target in patients with ESCC and that KAT8 inhibitor is a promising lead candidate for ESCC therapy.…”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…The ability of nanoherbal formulations to deliver drugs to tumor cells in an improved permeability and retention manner, such as, cancer therapy while minimizing tissue damage, has been largely practiced in many laboratories. …”
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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Background: Statins are the cornerstone of low-density lipoprotein cholesterol (LDL-C)-lowering therapy; however, the therapeutic efficacy of statins in countering atherosclerotic cardiovascular disease (ASCVD) is compromised by the concurrent elevation of proprotein convertase subtilisin/kexin type 9 (PCSK9), a pivotal molecule that increases LDL-C levels. …”
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Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats by M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych

“…Androgen deprivation therapy using gonadotropin-releasing hormone agonist remains the backbone of advanced prostate cancer treatment. …”
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Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP by Liyan Jiao, Hanping Li, Lin Li, Daomin Zhuang, Yongjian Liu, Zuoyi Bao, Siyang Liu, Jingyun Li

“…Methods. 646 bp HIV-1 pol gene fragments (from 592 to 1237 nucleotide) with different NNRTIs mutation profiles from AIDS patients receiving antiretroviral therapy containing NVP regimens were introduced into pNL4-3 backbone plasmid. …”
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Bibliometric analysis of laryngeal cancer treatment literature (2003–2023) by Yan Zhao, Jiancheng Xue

“…Current research hotspots include disease prognosis, models, clinical trials, tumor recurrence, and surveillance. Notably, targeted therapy and immunotherapy are rapidly advancing fields. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Eligible individuals were diagnosed with HIV, ≥40 years of age, naïve to antiretroviral therapy (ART), had no dementia at the index date and were followed for ≥1 year during 2002–2016. …”
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Identification of potential corticosteroid binding sites on the SARS CoV-2 main protease Mpro — in silico docking study by Н. В. Хміль, А. В. Шестопалова, В. Г. Колесніков, А. О. Боєчко-Немовча

“…A severe course of Covid-19 increases the duration of hospitalization and the mortality rate among the population. Pathogenetic therapy is carried out with systemic corticosteroids, which suppress the cytokine storm by mitigating the SARS-CoV-2-induced systemic inflammatory response and inhibit SARS-CoV-2 main protease Mpro, a key component of viral replication. …”
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Alpha-adrenergic receptor agonists in terms of modern views on glaucoma monitoring and treatment by V.P. Erichev, S.Yu. Petrov, A.V. Volzhanin, D.M. Safonova, T.V. Yaremenko, S.A. Kazaryan

“…Therefore, lifelong visual field monitoring and neuroprotective therapy are required. Brimonidine provides target IOP and prevents retinal cell death thus preserving vision in glaucoma.…”
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Trimethylamine Oxidation into the Proatherogenic Trimethylamine N-Oxide Is Higher in Coronary Heart Disease Men: From the CORDIOPREV Study by Helena Garcia-Fernandez, Juan F. Alcala-Diaz, Gracia M. Quintana-Navarro, Javier Lopez-Moreno, Diego Luque-Cordoba, Eugenia Ruiz-Diaz Narvaez, Antonio P. Arenas-de Larriva, Francisco M. Gutierrez-Mariscal, Jose D. Torres-Peña, Diego Rodriguez-Cano, Raul M. Luque, Feliciano Priego-Capote, Jose Lopez-Miranda, Antonio Camargo

Correlation between carbapenem susceptibility in Pseudomonas aeruginosa and modified antibiotic heterogeneity index: a multicenter observational study using a surveillance platform by Keisuke Sawada, Takaaki Kato, Shuji Kono, Hiromi Kaneko, Hayato Nakano, Shinobu Inada, Tatsuya Isogawa, Tadahiro Shimizu, Namiko Takahashi, Haruki Takano, Hiroaki Chiba, Makoto Sugimoto, Ryo Inose, Yuichi Muraki, Hideki Araoka

“…Indicators, such as the defined daily doses (DDDs), days of therapy (DOTs), antibiotic heterogeneity index (AHI), and mAHI, were analyzed for P. aeruginosa carbapenem susceptibility using Spearman’s rank correlation. …”
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Meta Analysis of Effectiveness on Acupuncture Assisted Rehabilitation after Total Knee Arthroplasty by LI Naping, YANG Shaofeng, KUANG Gaoyan, ZENG Fan, TU Duxing, LU Min

“…ObjectiveTo evaluate the effectiveness of acupuncture as adjuvant therapy for postoperative rehabilitation after total knee arthroplasty (TKA).MethodsThe randomized controlled trials (RCTs) of acupuncture assisted postoperative rehabilitation studies were searched from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, Cochrane Library and Web of Science. …”
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Confocal Microscopy for Detection of Intracellular Bacteria in Urine Samples of patients Suspected with Urinary Tract Infection: A Cross-sectional Observational Study by Bhagyashri Patil-Takbhate, Nilam Memane, Srikanth Tripathy, Nageswari Gandham, Shahzad Mirza

“…Hence diagnosis of IIB/IBC is crucial for the management of recurrent UTI and precise antibiotic therapy to avoid antibiotic resistance.…”
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Adsorption, in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides by Fangming Zhang, Hui Zheng, Tao Zheng, Pan Xu, Yao Xu, Yuxin Cao, Fan Jia, Yiqiong Zeng, Yubing Fan, Kai He, Xinwen Dai, Fengfei Hou, Yong Yang

“…Considering the beneficial role of dietary fiber and the traditional use of PC, ASP may also contribute substantially to the therapy function of PC. Compared to WSP, little attention has been paid to ASP and ASP modified product carboxymethyl poria polysaccharide (CMP) which has been used as an antitumor adjuvant drug. …”
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Expression profile of Bcl‐2 family proteins in newly diagnosed multiple myeloma patients by Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Ignacio J. Cardona‐Benavides, Myriam Cuadrado, Isabel Isidro, María‐José Calasanz, Manuela Fernandez, Ramón García‐Sanz, Noemi Puig, M. Teresa Cedena, Bruno Paiva, Laura Rosiñol, Joaquín Martínez‐López, Joan Bladé, Juan J. Lahuerta, Jesús F. San Miguel, María V. Mateos, Luis A. Corchete, Norma C. Gutiérrez, GEM/PETHEMA cooperative study group

“…Bcl‐2 protein ratios predicting sensitivity to venetoclax in vitro were also able to distinguish patients with shorter time to progression after triplet‐based induction therapy and ASCT. This is the first study to assess the expression of the most important Bcl‐2 family proteins by a quantitative method in a large set of MM patients according to their cytogenetic abnormalities. …”
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Phenotypes of primary sclerosing cholangitis in children by M.B. Dyba, V.S. Berezenko

“…Although immunosuppressive therapy is effective in controlling autoimmune inflammation, it does not inhibit the progression of fibrotic changes around the bile ducts, which, unfortunately, leads to the formation of biliary cirrhosis of the liver. …”
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Idiopathic multicentric Castleman disease in children: a single-center retrospective analysis by Junye Du, Jiafeng Yao, Honghao Ma, Li Li, Ang Wei, Liping Zhang, Dong Wang, Zhigang Li, Rui Zhang, Tianyou Wang

“…Conclusion Children with multicentric CD often have systemic symptoms, lymph node enlargement and related compression symptoms are the most common manifestations, followed by fever, malaise and other systemic symptoms. Anti-IL-6-based therapy combined with hormones lenalidomide and other medications have a specific therapeutic effect on multicentric CD.…”
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Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy by Marco Delle Monache, Alessio Petrelli, Alessandra Rossi, Roberto Cecere, Concetta Mirisola, Gianfranco Costanzo, Chiara Francia, Federica Cerini, Andrea Cavani, Lorenzo Nosotti

“…In 66 patients followed up for 24 months, HBV-DNA increased by ≥2000 UI/ml after 12 months in 15 individuals and remained ≥2000 UI/ml after 24 months in 10/15 individuals. 7/10 patients showed LS ≥ 7.5 kPa after 24 months, and 4 of them underwent antiviral therapy for HBV. Patients with HBV-DNA <2000 IU/ml had a significantly lower LS than those with HBV-DNA ≥2000 IU/ml (5.30 ± 1.43 vs. 7.69 ± 1.07, p<0.0001). …”
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Allergen immunotherapy in Italy: How, when, and why—A real-world study conducted through a patient association by Giovanni Paoletti, MD, Emanuele Nappi, MD, Maria Chiara Bragato, MD, Paola Valli, MD, Mattia Giovannini, MD, Domenico Gargano, MD, Luca Pecoraro, MD, Deborah Diso, MSc, Simona Barbaglia, MSc, Giorgio Walter Canonica, MD, Enrico Heffler, MD, PhD

“…Only 53.8% knew about AIT's existence, and AIT was proposed to only 33.1% of the 858 patients affected by allergic rhinitis and/or allergic asthma, of which 29.2% decided not to initiate the therapy. Common reasons for AIT refusal were related to indecisiveness (26.5%), costs (22.9%), and skepticism (19.3%). …”
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