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18661
Effect of anastomotic reinforcement with barded suture on anastomotic leakage prevention following laparoscopic low anterior resection for rectal cancer: a retrospective single-cen...
Published 2025-01-01“…In multivariate regression analyses, the neoadjuvant therapy (OR = 11.994, P < 0.01), tumor location (OR = 5.306, P = 0.015), anastomosis bleeding (OR = 58.822, P < 0.01), and number of staple firings used (≥ 3) (OR = 24.752, P < 0.01) were independent risk factors for AL, whereas the defunctioning stoma (OR = 0.051, P < 0.01) and reinforcing sutures (OR = 0.054, P = 0.001) were independent protective factors for AL in this study. …”
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18662
Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machin...
Published 2025-01-01“…Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, and programmed cell death (PCD) is increasingly recognized as a potential target in cancer therapy and prognosis. However, a PCD-based predictive model for serous ovarian carcinoma (SOC) is lacking. …”
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18663
Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells
Published 2022-04-01“…Novel and more effective therapies than those currently available are, therefore, urgently needed. …”
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18664
Hiatal Hernia Repair with Gore Bio-A Tissue Reinforcement: Our Experience
Published 2014-01-01“…Several trials strongly support surgery as an effective alternative to medical therapy. Today, laparoscopic fundoplication is considered as the procedure of choice. …”
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18665
Prevention and management of cytomegalovirus infection and disease in kidney transplant: A consensus statement of the Transplantation Society of Taiwan
Published 2025-02-01“…CMV prophylaxis was suggested after anti-thymocyte globulin treatment but not after methylprednisolone pulse therapy. Routine surveillance after prophylaxis, secondary prophylaxis after CMV disease treatment, and mTOR inhibitors for primary CMV prophylaxis were not recommended. …”
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18666
Fotobiomodulación vascular en el tratamiento de niños con transtornos temporomandibulares
Published 2024-12-01“…El láser que se usó es de la marca DMC Therapy Ec potencia 100 mW ±20%, longitud de onda 660nm ±10 nm, rojo, el parámetro de energía 120J, de aplicación continua. …”
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18667
Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease?
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18668
Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells
Published 2025-01-01“…This study promisingly repurposed five drugs for KRAS mutant lung cancer, of which cefadroxil, and cortisone are particularly warranting further assessment either as a standalone or combination therapy while capreomycin is still an effective inhibitor for KRAS G12C mutant as evident from in silico and in vitro studies.…”
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18669
Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models
Published 2025-01-01“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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18670
Fully automated extraction of high-quality total nucleic acids from FFPE specimens for comprehensive genomic profiling of solid tumors
Published 2025-04-01“…By identifying actionable mutations through next-generation sequencing of solid tumors CGP enables targeted therapy decisions. Formalin-fixed paraffin-embedded tissues are notoriously difficult samples in respect to reliably extracting high-quality nucleic acids and sufficient genetic material to meet sequencing input requirements. …”
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18671
Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation
Published 2025-01-01“…This study explored the role of the brain-derived neurotrophic factor(BDNF) and its associated receptor tropomyosin-receptor kinase B(TrkB) while deciphering the underlying mechanisms in transcranial direct current therapy to treat ischemic stroke. Methods: A middle cerebral artery occlusion-reperfusion(MCAO/R) model was established in rats to observe tDCS effects on brain damage. …”
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18672
Metabolomic profiling and antibacterial efficacy of probiotic-derived cell-free supernatant encapsulated in nanostructured lipid carriers against canine multidrug-resistant bacteri...
Published 2025-01-01“…The CFS-NLCs maintained their antibacterial activity and 30–60% dilutions of product completely inhibited the growth of pathogen strains even after three-months storage at room temperature.ConclusionThese findings suggest that CFS-NLCs could be a promising biotic therapy for treating hospital infections such as canine dermatitis and otitis caused by multidrug-resistant P. aeruginosa and S. pseudintermedius.…”
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18673
Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry
Published 2020-06-01“…From the 7984 patients, 56.73% were on regular blood transfusions and 61.72% were on chelation therapy. A small fraction (14.23%) has undergone splenectomy, while the percentage of patients with severe iron overload (serum ferritin ≥5000 µg/L) reduced over time. …”
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18674
Ambulatory Surgery for Perianal Crohn’s Disease: Study of Feasibility
Published 2018-01-01“…It might provide several benefits, including patients’ logistics, reduce or remove patients’ symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications.…”
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18675
Effects of Repetitive Transcranial Magnetic Stimulation Combined with Balance Acupuncture Treatment on Sleep Quality and Psychology in Patients after Stroke
Published 2024-02-01“…After 4 weeks of treatment, the serum level of 5-HT in the three groups increased significantly (<italic>P</italic><0.05); compared with the balance acupuncture group and the rTMS group, the level of 5-HT in the combination group was significantly higher (<italic>P</italic><0.05); there were no significant difference in 5-HT content between the balance acupuncture group and the rTMS group (<italic>P</italic>>0.05).ConclusionBoth rTMS and balance acupuncture therapy can improve sleep quality and psychology in patients after stroke. …”
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18676
Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial
Published 2025-01-01“…ObjectiveThis study aimed to assess the effectiveness of an AI-based prediction tool in providing patients with information about potential complications from ureteroscopy and ureteric stent placement and indicating the need for early additional therapy. MethodsOverall, 28 patients (aged 20-70 years) who underwent ureteral stent insertion for the first time without a history of psychological illness were consecutively included. …”
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18677
Survival after Locoregional Treatments for Hepatocellular Carcinoma: A Cohort Study in Real-World Patients
Published 2012-01-01“…All patients first diagnosed with HCC and treated with any locoregional therapy from 1998 to 2002 in twelve Italian hospitals were eligible. …”
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18678
Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease
Published 2025-01-01“…., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10‐fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC‐1α axis to regulate the mitochondrial function, providing a multi‐dimensional PD therapy. The asynchronous release of OACDP hydrogel provides a new conception for PD treatment and other neurodegenerative diseases.…”
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18679
Pengaruh Pesan Keagamaan Dalam Nadham Maulid Al-Dhiyâ’ Al-Lâmi’ Terhadap Jamaah Majelis Taklim Al-Hidayat Gampong Peulanggahan Banda Aceh; Kajian Ritual Effect
Published 2024-08-01“…The findings are as follows: First, the content includes messages of monotheism, praise for the Prophet, nobility, lineage, praises for the birth, and prophetic history; second, the religious impact on the lives of the congregation and the Acehnese community includes increased faith, love for the Prophet, adherence to Allah’s Sharia and the Prophet’s Sunnah, blessed life, improved morals, psychological therapy, and strengthened social relationships; third, the ritual art of reciting Nadham Maulid Al-Dhiyâ’ Al-Lâmi’ can be preserved due to the attraction to the familial network of the Prophet known as Ahlul Bait, as well as the traditional Hadrah music تركز هذه الدراسة على تحليل الرسائل الدينية في الطقوس القرائية لنظم مولد الضياء اللامع، وتأثيره على جماعة مجلس التعليم الهدى والمجتمع، وكذلك دوافع واستراتيجيات الحفاظ عليه باستخدام نهج تأثير الطقوس. …”
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18680
LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer
Published 2025-03-01“…Analyzing the relationship between LRP1 and HER2, we observed that an anti-HER2 targeted therapy reversed LRP1 overexpression induced by FHIT silencing whereas LRP1 silencing did not affect HER2 activity. …”
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