Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury by Linzhong Yang, Yuanchen Liu, Cheng Tao, Zichen Cao, Shilin Guo, Zheng Wei, Yanyi Wang, Tao Liu, Lin Chen, Ke Xiong, Xingyu Luo, Jianchuan Ran, Wei Han

“…At the same time, urokinase (UK), a key pharmaceutical agent in antithrombotic therapy, has been effectively incorporated into the system, enhancing its ability to prevent and treat thrombosis. …”
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Thoracolumbar fascia ultrasound shear strain differs between low back pain and asymptomatic individuals: expanding the evidence by Norio Tomita, Marie-Hélène Roy-Cardinal, Boris Chayer, Stacey Daher, Ameer Attiya, Aline Boulanger, Nathaly Gaudreault, Guy Cloutier, Nathalie J. Bureau

“…A brief standardized massage therapy technique did not influence elastography parameters. …”
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Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial by Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A. Sheth, Priya Rao, Kanishka Sircar, Amishi Y. Shah, Amado J. Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D. Chin, Nizar M. Tannir, Linghua Wang, Jianjun Gao

“…Abstract We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. …”
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Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord inju... by Natalia Comino-Suárez, Juan C. Moreno, Álvaro Megía-García, Antonio J. del-Ama, Diego Serrano-Muñoz, Juan Avendaño-Coy, Ángel Gil-Agudo, Mónica Alcobendas-Maestro, Esther López-López, Julio Gómez-Soriano

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Tannin alleviated reproductive dysfunction in pregnant ewes infected with Haemonchus contortus by Xin Li, Xin Li, Hai Xiang, Hai Xiang, Rong Liang, Rong Liang, Xinyu Han, Xinyu Han, Rongzhen Zhong, Rongzhen Zhong, Hongyu Liu, Hongyu Liu, Yi Fang, Yi Fang

“…The objective of this study was to evaluate the impact of dietary tannin supplementation on fecal egg count (FEC), packed cell volume (PCV), complete blood count (CBC), hormone levels, inflammatory markers, placental inflammation, and fetal growth and development in pregnant ewes infected with H. contortus.MethodsHulunbuir ewes were randomly divided into three groups: control group (CON), gastrointestinal nematode infection group (GIN), and tannin group, which was infected by H. contortus with tannin feeding therapy (TAN). After artificial insemination was completed, and the ewes were confirmed for pregnancy and infection; stools were collected for FEC, and blood samples were collected for PCV and CBC, hormonal, and inflammation levels. …”
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Effect of Ingestion Training Guided by Volume-viscosity Swallow Test on Post-Stroke Dysphagia by DENG Li, HE Yingzi, JIN Yanping, LU Yan

“…The control group received traditional rehabilitation training, such as conventional therapy, cold stimulation training, mouthwash and so on, 15 minutes a time, twice a day, six days a week, lasting for eight weeks. …”
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Effect of acupoint application combined with moxibustion in the treatment of postoperative constipation in patients with thoracolumbar compression fracture (艾灸联合穴位贴敷治疗胸腰椎压缩性骨折患者术后便... by WANG Tingting (王亭亭), LIU Fei (柳菲), NIE Shanshan (聂珊珊), YANG Qiujing (杨秋景), YANG Yang (杨杨)

“…Objective To observe the therapeutic effect of acupoint application therapy combined with moxibustion on postoperative constipation in patients with thoracolumbar compression fracture. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People Living With HIV Attending Centre of Excellence in HIV Care at a Tertiary Level Teaching Hospital in North... by Ragini Ram, Anuradha Subramanian MD, MSc, FRCP, Rajeshwari K. MD, PhD, FRCPCH

“…With the availability of free antiretroviral therapy (ART) across India, HIV in adults has become a chronic disease with prolonged survival. …”
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The dose–effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis by Xiaoni Zhang, Xiaoni Zhang, Yue Wang, Chengyong Liu, Shan Qin, Liyu Lin, Liyu Lin, Can Dong, Wenzhong Wu, Wenzhong Wu, Zhaoming Chen

“…In addition, there were no differences between acupuncture and SATV (sham acupuncture therapy at verum points) on the same acupuncture points in the PSQI scores. …”
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A Mobile Health Intervention to Support Collaborative Decision-Making in Mental Health Care: Development and Usability by Kristin Lie Romm, Mari Skoge, Elizabeth Ann Barrett, Lars-Christian Berentzen, Dagfinn Bergsager, Pål Fugelli, Thomas Bjella, Erlend Strand Gardsjord, Kristine Kling, Sindre Hembre Kruse, Kari Jorunn Kværner, Ingrid Melle, Erlend Mork, Henrik Myhre Ihler, Eline Borger Rognli, Carmen Simonsen, Tor Gunnar Værnes, Sofie Ragnhild Aminoff

“…Thus, iTandem includes the following 8 modules, primarily based on the needs of service users and clinicians: Sleep (sleep diary), Medication (intake and side effects), Recovery (measures, including well-being and personal recovery, and exercises, including good things and personal strengths), Mood (mood diary and report of daily feelings), Psychosis (level of positive symptoms and their consequences and level of negative symptoms), Activity (goal setting and progress), Substance use (weekly use, potential triggers or strategies used to abstain), and Feedback on therapy (of individual sessions and overall rating of the past week). …”
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Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies by Essam M. Abdelfattah, Essam M. Abdelfattah, Pius S. Ekong, Emmanuel Okello, Emmanuel Okello, Tapakorn Chamchoy, Betsy M. Karle, Randi A. Black, Wagdy ElAshmawy, Wagdy ElAshmawy, David Sheedy, Deniece R. Williams, Terry W. Lehenbauer, Terry W. Lehenbauer, Barbara A. Byrne, Sharif S. Aly, Sharif S. Aly

“…Eight dairies used blanket AMD therapy at dry-off for all lactating cows, while the remaining two dairies did not use any AMD treatment at dry-off. …”
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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Methods This cohort study included 16,122 treatment-naive PLWH who initiated antiretroviral therapy (ART) at the Third People's Hospital of Shenzhen from 2005 to 2022. …”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…Further study is indicated to determine the optimal candidates for pCSI and sequential therapies.…”
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Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

“…Its management consists in systemic therapies combined to dyspnea relief procedures. Prior studies have tested hyperthermic intrathoracic chemotherapy to treat pleural carcinosis with interesting patient survival results. …”
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Towards a histological diagnosis of childhood small vessel CNS vasculitis by Maryam Nabavi Nouri, Anastasia Dropol, Pascal N. Tyrrell, Sheila Sheikh, Marinka Twilt, Jean Michaud, Benjamin Ellezam, Harvey B. Sarnat, Christopher Dunham, Peter W. Schutz, Julia Keith, David G. Munoz, Harry V. Vinters, Cynthia Hawkins, Susanne M. Benseler

“…Nine North American neuropathologists, blinded to patients’ presentation, diagnosis, and therapy, scored de-identified biopsies independently. …”
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Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody by Liqiu Ma, Yang Li, Yoshimitsu Sakamoto, Lin Xie, Saaya Suzuki, Yukari Yoshida, Li Sui, Gang Guo, Jialing Wen, Wangcai Ren, Kazuhiro Kakimi, Kensuke Osada, Akihisa Takahashi, Takashi Shimokawa

“…Conclusion: Our findings suggest that there is an optimal dose range for the abscopal effect generated with the CIRT combined with anti-CTLA4 antibody, and it highlights a new opportunity for increased induction efficiency of the abscopal effect of combination therapy.…”
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Application of psychological intervention combined with wet compress of Traditional Chinese Medicine in nursing of patients with diabetic foot ulcer (心理干预联合中药塌渍技术在糖尿病足溃疡护理中的应用)... by WANG Xiuyan (王秀燕), CAO Hongjing (曹红京), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), YANG Kun (杨坤), LI Lin (李林), TANG Hong (汤虹)

“…Objective To evaluate the psychological intervention combined with Traditional Chinese Medicine Ta stain therapy in nursing of patients with diabetic foot ulcer. …”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice.Methods and analysis A community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. Patients commencing therapy for microbiologically confirmed rifampicin-resistant or multidrug-resistant tuberculosis within the past 30 days will be recruited to the study. …”
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Predictive nursing for catheter dislocation in placement of peripheral central venous catheter (经外周静脉置入中心静脉导管脱出的预见性护理) by WANG Nanan (王楠楠), SU Guohua (苏国华), GUO Lian (郭连), WANG Yutao (王玉涛), E Haiyan (鄂海燕), LIU Yunchao (刘云超)

“…Peripherally inserted central venous catheters (PICC), showing advantages of easy-to-operate, safe, minimal invasion, long-term retention and easy-to-maintain, is widely used in transfusion therapy. However, catheter dislocation during placement may lead to unplanned extubation. …”
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Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge‐to‐Edge Repair in Patients With Atrial Fibrillation: A Single‐Center Observational Stu... by Jan‐Hendrik Schipper, Anne‐Sophie Sommer, Richard Julius Nies, Clemens Metze, Max Maria Meertens, Jonas Wörmann, Sebastian Dittrich, Jan‐Hendrik van den Bruck, Arian Sultan, Jakob Lüker, Daniel Steven, Christopher Hohmann, Roman Pfister, Stephan Baldus, Ingo Eitel, Christian Frerker, Tobias Schmidt

“…Background Mitral valve transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a viable therapy option in patients with severe mitral regurgitation and high surgical risk. …”
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