Transformative Gamified Binocular Therapy for Unilateral Amblyopia in Young Children: Pilot Prospective Efficacy and Safety Study by Wenqing Zhu, Shuneng Gu, Jian Li, Jin Lin, Chanling Hu, Rui Liu

“…Following at least 8 weeks of refractive correction, participants underwent binocular gamified digital therapy for 60 minutes per day, 5 days a week. The therapy used a roguelike shooting game delivered under binocular conditions through two independent channels with a real-time artificial intelligence visual engine. …”
Get full text

Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Here, we assessed changes in lung inhomogeneity in patients with type-2 high asthma treated with biological therapy and explored the relationship between inhomogeneity measures and conventional asthma disease markers.Methods This was an observational study of 91 severe type-2 high asthma patients recruited from a tertiary asthma clinic, of whom 67 subsequently started anti-IL5 or anti-IL5R biologics. …”
Get full text

Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis by Jason D. Pole, Cameron A. Mustard, Teresa To, Joseph Beyene, Alexander C. Allen

“…Exposure to corticosteroids during pregnancy was associated with a risk of asthma in childhood between 3–5 years of age: adjusted hazard ratio of 1.19 (95% confidence interval: 1.03, 1.39), with no association noted after 5 years of age: adjusted hazard ratio for 5–7 years was 1.06 (95% confidence interval: 0.86, 1.30) and for 8 or greater years was 0.74 (95% confidence interval: 0.54, 1.03). Antenatal steroid therapy appears to be an independent risk factor for the development of asthma between 3 and 5 years of age.…”
Get full text

Current evidence on the use of sugammadex for neuromuscular blockade antagonism during electroconvulsive therapy: a narrative review by Vivek Arora, Laurence Henson, Sandeep Kataria

Subjects: “…electroconvulsive therapy…”
Get full text

A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

Get full text

Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

Subjects: Get full text

Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Finally, we briefly summarize the synapse-targeted drugs for dementia therapy.…”
Get full text

The Influence of Radiological “Disappearing Lesions” on the Efficacy and Prognosis of Patients with Colorectal Liver Metastases Undergoing Conversion Therapy by Zhi-yang Song, Dong Yang, Yang Liu, Yong Cheng

“…There was a statistical difference between chemotherapy alone and chemotherapy combined with the targeted therapy group on the occurrence of DLM (58.3% vs. 37.1%, P<0.001). …”
Get full text

The potential utility of phage therapy in the treatment of periprosthetic infection caused by multidrug-resistant pathogens: a review by Taalaibek U. Sheraliev, Alexander G. Samokhin, Baikozho R. Tashtanov, Andrey A. Korytkin, Vitaliy V. Pavlov

Subjects: Get full text

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL by Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne U. Hermansen, Norman Mack, Sibylle Ohl, Verena Kalter, Murat Iskar, Mathias Kalxdorf, Dennis Friedel, Mandy Rettel, Yashna Paul, Ingo Ringshausen, Eric Eldering, Julie Dubois, Arnon P. Kater, Marc Zapatka, Philipp M. Roessner, Eugen Tausch, Stephan Stilgenbauer, Sascha Dietrich, Mikhail M. Savitski, Sigrid S. Skånland, Jeroen Krijgsveld, Peter Lichter, Martina Seiffert

“…To investigate the underlying molecular mechanisms, we generate a mouse model of ibrutinib resistance, in which, after initial treatment response, relapse under therapy occurrs with an aggressive outgrowth of malignant cells, resembling observations in patients. …”
Get full text

Intracranial Hemorrhage Complicating Herpes Simplex Encephalitis on Antiviral Therapy: A Case Report and Review of the Literature by Ghada ElShimy, Christina Mariyam Joy, Fred Berlin, Waleed Lashin

“…We report a case of HSV encephalitis complicated by intracerebral hemorrhage 12 days after initiation of acyclovir therapy.…”
Get full text

Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation by Douglas W. Barrett, Christopher G. Beevers, F. Gonzalez-Lima

Subjects: “…Cognitive behavioral therapy…”
Get full text

Pelvic Floor Muscle Training vs. Vaginal Vibration Cone Therapy for Postpartum Dyspareunia and Vaginal Laxity by Federico Villani, Izabella Petre, Florina Buleu, Stela Iurciuc, Luciana Marc, Adrian Apostol, Chiara Valentini, Elisabetta Donati, Tommaso Simoncini, Ion Petre, Cristian Furau

“…Participants were assessed 3 months postpartum (T0) and after 3 months of therapy (T1) at the Pelvic Floor Rehabilitation Clinic of Santa Chiara Hospital, Pisa. …”
Get full text

The Significance of ST Depression in a Postmenopausal Woman on Estrogen Therapy during Regadenoson Myocardial SPECT Imaging by Nishaki Kiran Mehta, Charles Hardebeck, Martha Gulati

“…The incidence of false-positive stress tests has been noted in women, especially on hormone replacement therapy. Current literature describes this phenomenon in treadmill and adenosine stress tests. …”
Get full text

Effects of a Distributed Form of Constraint-Induced Movement Therapy for Clinical Application: The Keys Treatment Protocol by Sarah dos Anjos, Mary Bowman, David Morris

Subjects: “…constraint-induced movement therapy…”
Get full text

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

Subjects: Get full text

Systemic Therapy of Neuroendocrine Neoplasia: Single Center Experience from a Cohort of 110 Consecutive Cases by Karin Mayer, Selina Kiry, Anna Yordanova, Hojjat Ahmadzadehfar, Florian C. Gaertner, Ralph A. Bundschuh, Markus Essler, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Hanno Matthaei, Philipp Lingohr, Savita Bisht, Peter Brossart, Georg Feldmann

“…Peptide receptor radionuclide therapy (PRRT) and cytostatic chemotherapy were the second most common options, with PRRT being used more frequently in NET G1 and G2 and chemotherapy in NEC G3. …”
Get full text

Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report by Christian Koch, Patrick Roth, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Markus G. Manz, Simone Unseld, Antonia M. S. Müller, Norman F. Russkamp

“…Journal for ImmunoTherapy of Cancer…”
Get full text

Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration by Kangkang Zha, Zhiqiang Sun, Yu Yang, Mingxue Chen, Cangjiang Gao, Liwei Fu, Hao Li, Xiang Sui, Quanyi Guo, Shuyun Liu

Get full text

Effect of music therapy on emotional resilience, well-being, and employability: a quantitative investigation of mediation and moderation by Yingjie Feng, Mingda Wang

Subjects: “…Music therapy…”
Get full text