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18561
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer
Published 2025-01-01“…Treatment with folate-conjugated liposomes targeting breast cancer cells that contained both a CDK4/6i and WKYMVM revealed the synergistic effect of METTL14 inhibition with CDK4/6i therapy in a CDK4/6i-resistant PDX model. Together, our findings reveal the mechanism of CDK4/6i resistance and provide a strategy for overcoming CDK4/6i resistance via METTL14 inhibition. …”
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18562
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
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18563
Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production
Published 2025-12-01“…Antibodies used for cancer therapy are monoclonal IgGs, but tumor-targeting IgE antibodies have shown enhanced effector cell potency against cancer in preclinical models. …”
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18564
Effect of feedforward control combined with tracking method on reducing the incidence of blockage of intravenous indwelling needle in perioperative patients (前馈控制追踪法在降低围手术期患者静脉留置针堵...
Published 2023-03-01“…Totally 852 patients who received intravenous infusion therapy were recruited and divided into two groups according to the odd-even number of admission: 424 patients with odd number in the control group and 428 patients with even number in the observation group. …”
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18565
Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis
Published 2025-01-01“…Thus, MAT may be a promising target for adjuvant anti-BC therapy.…”
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18566
Effect of Shangke Zhitong Ointment Kinesio Tape on Ankle Sprain
Published 2023-04-01“…In addition, the control group received kinesio tape therapy; the combined group received kinesio tape and Shangke Zhitong ointment; the Shangke kinesio tape group received Shangke Zhitong ointment kinesio tape. …”
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18567
Correlation of HER2 expression and clinicopathological characteristics in patients with urothelial carcinoma in China
Published 2024-11-01“…This study underscores the critical importance of accurately assessing HER2 expression in UC patient to guide personalized therapies.…”
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18568
The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency
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18569
A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Fol...
Published 2019-01-01“…The Mean Blood Glucose (MBG) of the two groups declined significantly after therapy (P<0.05). However, the Standard Deviation of Blood Glucose (SDBG) decreased significantly only in the dulaglutide group (from 2.57±0.74 mmol/L to 1.98±0.74 mmol/L, P<0.05). …”
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18570
Effect of Tonifying deficiency and Zhengqi porridge on immune function reconstruction in HIV/AIDS patients with Qi deficiency (补虚正气粥对艾滋病气虚型患者免疫功能重建的影响研究)...
Published 2022-11-01“…All patients received the highly active anti-retroviral therapy, and those in the treatment group were given Tonifying deficiency and Zhengqi porridge. …”
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18571
Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study
Published 2024-12-01“…Patients were required to have an implanted cardiac defibrillator (ICD) or cardiac resynchronization therapy (CRT) device because of the potential for bradycardia or AV conduction delay, which may be induced by BAY 2413555. …”
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18572
Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis
Published 2024-09-01“…Interestingly, 26-3 can also sensitize tumor cells to Gefitinib therapy. Mechanistically, through RNA-seq analysis, we found that 26-3 could abrogate the CDDP-induced upregulation of Polη and PIDD (p53-induced protein with a death domain), 2 known factors promoting TLS pathway. …”
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18573
Understanding the long‐term impact of the COVID‐19 pandemic on non‐muscle‐invasive bladder cancer outcomes: 12‐Month follow‐up data from the international, prospective COVIDSurg Ca...
Published 2024-11-01“…As a consequence of the COVID‐19 pandemic, 10.9% of patients had site‐declared delay to TURBT/bladder biopsy; 7.4% did not undergo intravesical therapy or had early discontinuation of this; 9.2% did not undergo early repeat resection for high‐risk disease; and 18.3% had a delay to cystoscopic follow‐up surveillance. …”
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18574
c-MET-positive circulating tumor cells and cell-free DNA as independent prognostic factors in hormone receptor-positive/HER2-negative metastatic breast cancer
Published 2024-01-01“…Abstract Background Endocrine therapy resistance in hormone receptor-positive/HER2-negative (HR+/HER2−) breast cancer (BC) is a significant clinical challenge that poses several unmet needs in the management of the disease. …”
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18575
Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved
Published 2025-02-01“…., optimism and hopelessness), therapies more focused on the meaning of existence, such as Acceptance and Commitment Therapy, could be useful.…”
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18576
Safety and efficacy of catheter ablation in atrial fibrillation patients with heart failure with preserved ejection fraction
Published 2025-01-01“…Methods Three groups of AF patients were included in the study: 187 patients with HFPEF for their first CA (AFPHF-CA), 187 patients with HFPEF who were undergoing medical therapy (AFPHF-Med), and 196 patients without HFPEF for their first CA (AF-CA). …”
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18577
Radiotherapy(R) Integration(I) Strategy for Small(S)-Cell Lung Cancer in Extensive(E) Stage (RISE) with up to 10 metastases- a study protocol of a randomized phase II trial
Published 2025-01-01“…There is a lack of data on incorporating RT as chest consolidation and metastasis-directed therapy for ED-SCLC. The RISE (Radiotherapy for Extensive-Stage Small-Cell Lung Cancer) study aims to evaluate the effectiveness of different RT strategies for residual lesions for patients with ED-SCLC who receive chemo-immunotherapy. …”
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18578
Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides
Published 2025-02-01“…Non-thermal atmospheric pressure plasma irradiation therapy is attracted attention as it exerts beneficial effects by producing various reactive molecular species. …”
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18579
Effect of salmon calcitonin on bone mineral density of patients with osteoporotic vertebral compression fractures (鲑降钙素对骨质疏松椎体压缩性骨折患者骨密度的影响)...
Published 2023-05-01“…The control group received routine antiosteoporosis therapy(Teriparatide and Chinese medicine capsules for osteoporosis), and the study group was given salmon calcitonin combined with Chinese medicine capsules for osteoporosis. …”
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18580
Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis
Published 2025-01-01“…Further rigorous trials are warranted to confirm SMC’s short-term efficacy and explore its medium- to long-term effects as either an alternative or complementary therapy. Current evidence precludes recommendations for the administration of SMC in depression.Keywords: Chinese patent medicine, commercial Chinese polyherbal preparation, Chinese medicine, herbal medicine, depressive disorder, major depressive disorder, sleep quality…”
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