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  1. 18521

    Brimonidine as an additional treatment for moderate glaucoma by I.R. Gazizova, V.E. Korelina

    Published 2021-05-01
    “…</i> </p> <p> <i><b>Conclusion</b>: brimonidine as an additional treatment for moderate and advanced glaucoma results in stable IOP reduction. Combined therapy which includes brimonidine preserves visual functions even in moderate-to-advanced glaucoma. …”
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  2. 18522

    Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

    Published 2025-01-01
    “…Here, we investigated the in vitro effects of the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil on human pancreatic PANC-1 and colorectal SW-620 cancer cell lines to understand further cellular behaviors and the potential risks of their use in cancer therapy. For the first time, the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil significantly altered cancer cells in forming missile-like shapes to induce tunneling nanotube (TNT) communications in PANC-1 cells. …”
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  3. 18523
  4. 18524

    Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

    Published 2025-01-01
    “…Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. …”
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  5. 18525

    Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review by Yingna Gao, Xiaoqiong Shi, Jianqiao He, Hui Yao, Guoning Yu, Lin Zhao, Yi Ma, Yi Ma, Hongliang Zheng, Minhui Zhu, Caiyun Zhang

    Published 2025-01-01
    “…Therefore, this treatment strategy is recommended as a first-line therapy for RM-NPC. However, whether dmNPC can be treated with immunochemotherapy alone (without LRRT) remains controversial.Case presentationWe report two cases of dmNPC, both in middle-aged men who mainly presented with epistaxis and systemic pain. …”
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  6. 18526

    Mailed smoking cessation support for Aboriginal and Torres Strait Islander people who smoke: protocol for a hybrid type 1 effectiveness – implementation trial by Raglan Maddox, Catherine Chamberlain, Billie Bonevski, Amanual Getnet Mersha, Jamie Bryant, Michelle Kennedy, Nathan Taylor, Cathy Segan, Kayden Roberts-Barker, Zabowie Mills, Kade Booth, Joley Foster

    Published 2024-12-01
    “…This study will assess the implementation and effectiveness of a mailed smoking cessation support programme that includes nicotine replacement therapy (NRT) (Which Way Quit Pack) for Aboriginal and Torres Strait Islander people.Methods and analysis A hybrid type 1 effectiveness—implementation trial will be conducted in Australia from 2023 to 2025. …”
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  7. 18527

    Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient by Stéfanie Parisien-La Salle, Florence Perreault, Gilles Corbeil, Julie Morisset, Charles Poirier, Catherine Beauregard, Agnès Räkel, Marjorie Labrecque, Martine Tétreault, Martine Tétreault, Christian Cohade, Pasquale Ferraro, Isabelle Bourdeau

    Published 2025-02-01
    “…He required home oxygen therapy for 3 years prior to transplant. Nineteen years after transplant, a CT-scan revealed a 5.8 cm x 3.9 cm heterogeneous right adrenal mass (HU of 7). …”
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  8. 18528

    Immunosenescence and its related comorbidities in older people living with HIV by Xiao-Yan He, Xiu-Wen Wang, Shuang Li, Na Li, Wei Li, Yan Hu, Na Guo, Yong-Tang Zheng, Hong-Yi Zheng, Bin Su, Haijuan Wang

    Published 2025-01-01
    “…Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of age-related comorbidities, such as cardiovascular disease, bone disease, and cognitive impairment. …”
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  9. 18529

    Blueberry malvidin-3-galactoside modulated gut microbial dysbiosis and microbial TCA cycle KEGG pathway disrupted in a liver cancer model induced by HepG2 cells by Zhen Cheng, Jie Lin, Ningxuan Gao, Xiyun Sun, Xianjun Meng, Ruihai Liu, Yunen Liu, Weisheng Wang, Bin Li, Yuehua Wang

    Published 2020-09-01
    “…Taken together, these results demonstrate that the blueberry M3G has the potential to be an intestinal microbiota regulator and an adjuvant to HCC therapy.…”
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  10. 18530

    Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

    Published 2025-01-01
    “…The current lack of reliable predictive biomarkers hinders early diagnosis and personalized therapy.MethodsTranscriptomic profiles of DN samples and controls were extracted from GEO databases. …”
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  11. 18531

    Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study by Mustafa Ferudun Celikmen, Gülbin Aydoğdu Umaç, Melih Imamoglu, Mümin Murat Yazici, Elif Çiğdem Keleş, Sarper Yilmaz

    Published 2025-01-01
    “…The most common interventions provided to the injured were intravenous fluid therapy (63.8%, n =102) and oxygen support (57.5%, n =92). …”
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  12. 18532

    Feasibility of HIV self-test implementation among Mizo youths: a field investigation from Northeast India bordering Myanmar by Amrita Rao, Henry Zodinliana Pachuau, Samiran Panda, Richard L. Chawngthu, Rita Zomuanpuii, Pranoti Hemade, Amit Nirmalkar

    Published 2025-02-01
    “…IntroductionThis study investigated the potential of HIV self-test (HIVST) to reach individuals who otherwise might not access testing or antiretroviral therapy (ART). The study had two main objectives: (a) to develop an HIV self-test implementation plan based on the findings from qualitative inquiries with local stakeholders and (b) to examine HIVST uptake among youths in the urban setting of Aizawl district in Mizoram.MethodologyIn the first phase, qualitative in-depth interviews (IDI) were conducted with HIV program officials, religious leaders, community influencers, youths, and key population groups. …”
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  13. 18533

    Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ... by Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, Jonas Mattsson, MD, PhD

    Published 2025-02-01
    “…Multivariate logistic regression analysis identified mismatched donors (odds ratio, 1.72; 95% confidence interval, 1.03-2.88; P = 0.038) and the duration of G-CSF therapy (odds ratio, 1.04; 95% confidence interval, 1.00-1.09; P = 0.038) as independent predictors for the development of ES. …”
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  14. 18534

    The Suppression of Signal Transducer and Activator of Transcription-3 in A549&nbsp;human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa by Hadisaputri YE, Nurhaniefah AA, Mutakin M, Hendriani R, Rezano A, Sopyan I, Yusnaini Y, Asikin Y, Abdulah R

    Published 2025-01-01
    “…These results suggested their promising candidacy for future anti-angiogenesis in anticancer therapy.Keywords: Callyspongia aerizusa, A549 cells, PI3K/Akt signaling, STAT-3, wound healing, invasion…”
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  15. 18535

    Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

    Published 2025-01-01
    “…Objectives: Chronic kidney disease (CKD) is a progressive illness with a high rate of morbidity and mortality with no proven therapy. Alterations of amino acid(AA) metabolism are associated with the incidence and progression of CKD. …”
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  16. 18536
  17. 18537

    TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se... by Sophie Zaloumis, Matthew J. Summers, Jeffrey J. Presneill, Rinaldo Bellomo, Lee-anne S. Chapple, Marianne J. Chapman, Adam M. Deane, Suzie Ferrie, Craig French, Sally Hurford, Nima Kakho, Matthew J. Maiden, Stephanie N. O’Connor, Sandra L. Peake, Emma J. Ridley, An Tran-Duy, Patricia J. Williams, Paul J. Young, Amalia Karahalios, on behalf of the TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group

    Published 2025-02-01
    “…Secondary outcomes include proportion of patients alive at day 90, survivor-only analysis of days free of the index hospital at day 90, duration of invasive ventilation, ICU and hospital length of stay, incidence of tracheostomy insertion, renal replacement therapy, and discharge destination. The statistical methods and models which will be used to estimate the effects for the primary and secondary outcomes are described. …”
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  18. 18538
  19. 18539
  20. 18540

    Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan by A. V. Nersesov, D. A. Kaybullaeva, V. S. Rakhmetova, I. A. Lozinskaya, A. K. Kurmangalieva, V. S. Ayupova, A. B. Orazbaeva, A. K. Kanabaeva, Yu. O. Shulpekova

    Published 2022-01-01
    “…The objectives of the study included collection of clinical characteristics of patients, evaluation of Odeston effects in treatment of biliary pain and changes in the gallbladder emptying, evaluation of compliance to therapy, and treatment effect satisfaction.Materials and methods. …”
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