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18521
Brimonidine as an additional treatment for moderate glaucoma
Published 2021-05-01“…</i> </p> <p> <i><b>Conclusion</b>: brimonidine as an additional treatment for moderate and advanced glaucoma results in stable IOP reduction. Combined therapy which includes brimonidine preserves visual functions even in moderate-to-advanced glaucoma. …”
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18522
Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel...
Published 2025-01-01“…Here, we investigated the in vitro effects of the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil on human pancreatic PANC-1 and colorectal SW-620 cancer cell lines to understand further cellular behaviors and the potential risks of their use in cancer therapy. For the first time, the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil significantly altered cancer cells in forming missile-like shapes to induce tunneling nanotube (TNT) communications in PANC-1 cells. …”
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18523
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18524
Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy
Published 2025-01-01“…Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor-infiltrating macrophages. …”
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18525
Immunotherapy combined with chemotherapy without locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: two case reports and a literature review
Published 2025-01-01“…Therefore, this treatment strategy is recommended as a first-line therapy for RM-NPC. However, whether dmNPC can be treated with immunochemotherapy alone (without LRRT) remains controversial.Case presentationWe report two cases of dmNPC, both in middle-aged men who mainly presented with epistaxis and systemic pain. …”
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18526
Mailed smoking cessation support for Aboriginal and Torres Strait Islander people who smoke: protocol for a hybrid type 1 effectiveness – implementation trial
Published 2024-12-01“…This study will assess the implementation and effectiveness of a mailed smoking cessation support programme that includes nicotine replacement therapy (NRT) (Which Way Quit Pack) for Aboriginal and Torres Strait Islander people.Methods and analysis A hybrid type 1 effectiveness—implementation trial will be conducted in Australia from 2023 to 2025. …”
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18527
Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient
Published 2025-02-01“…He required home oxygen therapy for 3 years prior to transplant. Nineteen years after transplant, a CT-scan revealed a 5.8 cm x 3.9 cm heterogeneous right adrenal mass (HU of 7). …”
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18528
Immunosenescence and its related comorbidities in older people living with HIV
Published 2025-01-01“…Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of age-related comorbidities, such as cardiovascular disease, bone disease, and cognitive impairment. …”
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18529
Blueberry malvidin-3-galactoside modulated gut microbial dysbiosis and microbial TCA cycle KEGG pathway disrupted in a liver cancer model induced by HepG2 cells
Published 2020-09-01“…Taken together, these results demonstrate that the blueberry M3G has the potential to be an intestinal microbiota regulator and an adjuvant to HCC therapy.…”
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18530
Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence
Published 2025-01-01“…The current lack of reliable predictive biomarkers hinders early diagnosis and personalized therapy.MethodsTranscriptomic profiles of DN samples and controls were extracted from GEO databases. …”
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18531
Comparison of search and rescue operations involving emergency physicians in devastating earthquakes in Turkey: a 24-year experience study
Published 2025-01-01“…The most common interventions provided to the injured were intravenous fluid therapy (63.8%, n =102) and oxygen support (57.5%, n =92). …”
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18532
Feasibility of HIV self-test implementation among Mizo youths: a field investigation from Northeast India bordering Myanmar
Published 2025-02-01“…IntroductionThis study investigated the potential of HIV self-test (HIVST) to reach individuals who otherwise might not access testing or antiretroviral therapy (ART). The study had two main objectives: (a) to develop an HIV self-test implementation plan based on the findings from qualitative inquiries with local stakeholders and (b) to examine HIVST uptake among youths in the urban setting of Aizawl district in Mizoram.MethodologyIn the first phase, qualitative in-depth interviews (IDI) were conducted with HIV program officials, religious leaders, community influencers, youths, and key population groups. …”
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18533
Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Differ...
Published 2025-02-01“…Multivariate logistic regression analysis identified mismatched donors (odds ratio, 1.72; 95% confidence interval, 1.03-2.88; P = 0.038) and the duration of G-CSF therapy (odds ratio, 1.04; 95% confidence interval, 1.00-1.09; P = 0.038) as independent predictors for the development of ES. …”
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18534
The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa
Published 2025-01-01“…These results suggested their promising candidacy for future anti-angiogenesis in anticancer therapy.Keywords: Callyspongia aerizusa, A549 cells, PI3K/Akt signaling, STAT-3, wound healing, invasion…”
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18535
Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease
Published 2025-01-01“…Objectives: Chronic kidney disease (CKD) is a progressive illness with a high rate of morbidity and mortality with no proven therapy. Alterations of amino acid(AA) metabolism are associated with the incidence and progression of CKD. …”
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18536
Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition...
Published 2022-06-01“…For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. …”
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18537
TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se...
Published 2025-02-01“…Secondary outcomes include proportion of patients alive at day 90, survivor-only analysis of days free of the index hospital at day 90, duration of invasive ventilation, ICU and hospital length of stay, incidence of tracheostomy insertion, renal replacement therapy, and discharge destination. The statistical methods and models which will be used to estimate the effects for the primary and secondary outcomes are described. …”
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18538
Age-related features of some plasminogen activation system components content and activity in the blood of benign and malignant uterine body tumors
Published 2024-09-01“…The results obtained can be used in research aimed at clarifying the targets of targeted therapy for LM and UCEC in accordance with the age of patients.…”
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18539
Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association
Published 2018-08-01“…Risk factors of C. difficile-associated include antibacterial therapy, hospital admission, elderly age, comorbidity and immunosuppressive treatment. …”
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18540
Hymecromone Administration in Real Clinical Practice: Results of the Prospective Multicentre Observational Study in the Republic of Kazakhstan
Published 2022-01-01“…The objectives of the study included collection of clinical characteristics of patients, evaluation of Odeston effects in treatment of biliary pain and changes in the gallbladder emptying, evaluation of compliance to therapy, and treatment effect satisfaction.Materials and methods. …”
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