Therapeutic Effect of High-Definition Transcranial Direct Current Stimulation Combined with Suspension Exercise Training on Lower Limb Motor Function of Stroke Patients by ZHANG Haiquan, HU Chuan, HUANG Lei, LU Wei, WANG Xin

“…The control group received conventional rehabilitation treatments such as exercise therapy and neuromuscular electrical stimulation, 25 minutes a day, once a day, 5 days a week for 8 weeks. …”
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Comprehensive treatment of the macular edema in patients with retinal vein occlusion and hemostasis system disturbances by T.V. Shelkovnikova, Kh.P. Takhchidi, G.V. Vavin, N.Yu. Barkova, N.Yu. Shishlyannikova

“…This will allow prescribing timely adequate anticoagulant, antiplatelet, antioxidant therapy and discrete plasmapheresis.<br> <br> <b>Key words:</b> retinal vein occlusion, macular edema, hemostasis, vascular endothelial growth factor, VEGF, lupus anticoagulant.…”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“… BACKGROUND AND OBJECTIVE: Because of the lack of effective targeted treatment options, docetaxel has long been the standard second-line therapy for patients with advanced non-small cell lung cancer, including the Kirsten rat sarcoma virus (KRAS) G12C mutation. …”
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Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…The potential of mesenchymal stem cells (MSCs) to differentiate into nonmesodermal cells such as pancreatic beta cells has been reported. New cell-based therapy using MSCs for diabetes mellitus is anticipated as an alternative treatment option to insulin injection or islet transplantation in both human and veterinary medicine. …”
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Analysis of Prognostis Factors and Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease by Yiming XU, Honghua SHEN, Jingbo DU, Lei REN

“…All patients were given the treatments: ①Routine medical treatment of COPD, included bronchodilator, hormones and β₂receptor agonist (the patients whose FEV1 accounted for less than 50%of the predicted value and having clinical symptoms were treated with inhaled hormones and β₂receptor agonist), and other expectorant and cough-relieving drugs.②Pulmonary rehabilitation education, included knowledge of COPD, pulmonary rehabilitation idea, smoking cessation, oxygen therapy, rational use of drugs and balanced nutrition, once a month.③Aerobic respiratory exercises, included lip contraction breathing and abdominal breathing training, 5 times a week, 20 minutes each time.④Aerobic exercise training, limited aerobic exercise with different intensity from low to high using randomized block design. …”
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Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Chronic itch which is primarily associated with dermatologic, systemic, or metabolic disorders is often refractory to most current antipruritic medications, thus highlighting the need for improved therapies. Oxidative damage is a novel determinant of spinal pruriceptive sensitization and synaptic plasticity. …”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…The present work is the first report in the series of papers from our group where we describe the development of anticancer therapy based on the selective targeting of TISCs. …”
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Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma by María L. Espejo-Cruz, Sandra González-Rubio, Juan J. Espejo, Javier M. Zamora-Olaya, María Prieto-Torre, Clara I. Linares, Álvaro Ruiz-Ramas, Álvaro Jiménez-Arranz, Marta Guerrero-Misas, Pilar Barrera-Baena, Antonio Poyato-González, José L. Montero, Marina Sánchez-Frías, María D. Ayllón, Manuel L. Rodríguez-Perálvarez, Manuel de la Mata, Gustavo Ferrín

“…Future studies should evaluate the role of CTC dynamics to select candidates for adjuvant therapy after TACE and to analyze their impact on long-term outcomes.…”
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Conhecimento dos pacientes com câncer avançado sobre seu diagnóstico e modalidade de tratamento by Leonel dos Santos Silva, Ana Paula Felicio de Lima, Cleo Watanabe Pisaia, Lourdes Maria Rosinski Lima Gomes, Natália Naome Oshiro, Paulo Ricardo Bittencourt Guimarães, Luciana de Alcantara Nogueira, Luciana Puchalski Kalinke

“…Results: A total of 101 participants were included, with a mean age of 56.8 years; 73.3% were women (p<0.05), 38.6% had breast cancer (p<0.05), and multiple metastases; 49.5% were aware of the advanced cancer diagnosis (p<0.05), 30.7% were unaware of the disease stage, 37.6% did not understand the treatment objectives, and 33.7% believed the treatment was curative; 94.1% had not been advised on non-pharmacological therapy by a healthcare professional (p<0.05). Conclusion: Patients showed limitations in understanding the stage of the disease, treatment objectives, and the use of non-pharmacological therapies.…”
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Long-term outcomes of combined optimized YAG-laser trabeculostomy and selective laser trabeculoplasty for primary open-angle glaucoma by A.S. Balalin, V.P. Fokin, S.V. Balalin, B.G. Dzhashi

“…Moreover, IOP-lowering therapy was canceled in 18.4% and 10.3% of patients, respectively. …”
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Impact of garlic polysulfide supplementation on biochemical and hematological parameters in dairy cows by Nedić Sreten, Gajić Mirjana, Bošnjaković Dušan, Vujanac Ivan, Prodanović Radiša, Bojkovski Jovan, Mitrović Aleksandra, Milenković Milan, Manojlović Dragan, Jovanović Ljubomir, Kirovski Danijela, Arsić Sveta

“…The aim of our study was to investigate the influence of garlic polysulfides, including diallyl polysulfide and dipropyl polysulfide, on hematological and biochemical parameters in dairy cows, as well as their possible effect on subclinical mastitis therapy. Eighteen late lactation Holstein cows were divided into three numerically equal groups (n=6): CON (non-supplemented cows), ALL (supplemented with 1000 mg/day of diallyl polysulfide), and PRP (supplemented with 1000 mg/day of dipropyl polysulfide). …”
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A head-to-head comparison of the adult EQ-5D-5L and youth EQ-5D-Y-5L in adolescents with idiopathic scoliosis by Joshua M. Bonsel, Charles M. M. Peeters, Max Reijman, Tim Dings, Joost P. H. J. Rutges, Diederik H. R. Kempen, Jan A. N. Verhaar, Gouke J. Bonsel

“…To assess which is most suitable, this study tested for equivalence along predefined criteria of the youth (EQ-5D-5L) and adult (EQ-5D-Y-5L) version in an adolescent population receiving bracing therapy for AIS. Methodology 107 adolescents were recruited from 4 scoliosis centers in the Netherlands between March 2022 and January 2023; they completed both EQ-5D’s and the SRS-22r (scoliosis-specific questionnaire). …”
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Kefir Prevents Adipose Tissue Growth Through the Induction of Apoptotic Elements in High-Fructose Corn Syrup-Fed Rats by Esra Aslan, Gokhan Sadi, Hilal Guzel, Cigdem Karaca, Omer Adil Korkmaz, Mine Kanat Pektas, Mehmet Celegen, Tugce Aladag, Seyma Oncu, Mehmet Bilgehan Pektas

“…This study evaluated the metabolic disturbances that are caused by HFCS on adipose tissue as well as the possibility of kefir as a therapy to prevent these metabolic disturbances. Male Wistar rats were divided into four groups: control, kefir, HFCS, and HFCS+kefir. …”
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Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Periphe... by Xu Y, Wu J, Jiang Q, Lv Y, Zhou J, Wang Z, Zhao H, Du D

“…The change of NRS, SF-MPQ-2, SSR latency and SSR amplitude in TEAS group were significantly higher than those in non-TEAS group at 3 weeks after therapy (all P< 0.01). In addition, the effective relief rate was significantly higher in TEAS group than in non-TEAS group (P=0.026). …”
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Adverse events associated with the delivery of telerehabilitation across rehabilitation populations: A scoping review. by Thomas Yau, Josh Chan, McKyla McIntyre, Damanveer Bhogal, Angie Andreoli, Carl Froilan D Leochico, Mark Bayley, Ailene Kua, Meiqi Guo, Sarah Munce

“…Understanding adverse events, such as falls during physiotherapy or aspiration pneumonia during speech therapy, is crucial for identifying limitations and optimizing delivery through risk mitigation and quality indicators. …”
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Epidemiology of Mucopolysaccharidosis Type II According to the Register of the Russian Federation by Natalia V. Buchinskaia, Ekaterina Yu. Zakharova, Yulia S. Koshevaya, Anastasia O. Vechkasova, Rostislav K. Skitchenko, Aleksandr M. Nikonov, Vera I. Kurilova, Yulia V. Maximova, Khasyanya F. Aksyanova, Elena G. Bakulina, Nina I. Kononenko, Elena V. Osipova, Mikhail M. Kostik, Sergei I. Kutsev

“…About 138 (87.3%) patients received enzyme replacement therapy. Conclusion: The prevalence of MPS II in the RF is higher than that in some European countries and closer to the Asian population. …”
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Measuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya by Victor Omollo, Stephanie D. Roche, Shengruo Zhang, Magdalene Asewe, Bernard K. Rono, Benn Kwach, Greshon Rota, Patricia Ong’wen, Kendall Harkey, Josephine Odoyo, Daniel Were, Kenneth Ngure, Elizabeth A. Bukusi, Katrina F. Ortblad

“…Based on their test result and recent self-reported behaviors associated with HIV risk, clients were encouraged to consider pre-exposure prophylaxis (PrEP), post-exposure prophylaxis (PEP), or antiretroviral therapy (ART) initiation, informed where they could access free services, and issued a referral. …”
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Retinoblastoma. Part 2.&nbsp; Treatment strategies for intraocular retinoblastoma by S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva

“…The volume of adjuvant therapy is based on the histological risk factors for disease progression. …”
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Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China by Mary Bachman DeSilva, Allen L. Gifford, Xu Keyi, Zhong Li, Cheng Feng, Mohamad Brooks, Mark Harrold, Hu Yueying, Christopher J. Gill, Xie Wubin, Taryn Vian, Jessica Haberer, David Bangsberg, Lora Sabin

“…Ten patients on antiretroviral therapy (ART) at the Guangxi CDC HIV clinic in Nanning, China, used Wisepill for one ART medication for one month. …”
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Ethanolic Extract of <i>Averrhoa carambola</i> Leaf Has an Anticancer Activity on Triple-Negative Breast Cancer Cells: An In Vitro Study by Oscar F. Beas-Guzmán, Ariana Cabrera-Licona, Gustavo A. Hernández-Fuentes, Silvia G. Ceballos-Magaña, José Guzmán-Esquivel, Luis De-León-Zaragoza, Mario Ramírez-Flores, Janet Diaz-Martinez, Idalia Garza-Veloz, Margarita L. Martínez-Fierro, Iram P. Rodríguez-Sanchez, Gabriel Ceja-Espíritu, Carmen Meza-Robles, Víctor H. Cervantes-Kardasch, Iván Delgado-Enciso

“…This study aimed to assess the effects of ethanolic extract from <i>A. carambola</i> leaves on triple-negative breast cancer (TNBC), an aggressive subtype lacking specific therapy. <b>Methods</b>: Phytochemical analysis and HPLC profile and additional cell line evaluation employing MDA-MB-231 were carried out. …”
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