The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review by Yulong Yang, Hailin Jiang, Wenming Yang, Wenming Yang, Wenming Yang, Han Wang, Han Wang, Meixia Wang, Meixia Wang, Xiang Li, Peng Huang, Shuzhen Fang, Wenjie Hao, Yue Yang, Furong Zhao, Wei He

“…Before his diagnosis, he was admitted multiple times, with symptoms improving following the addition of intravenous immunoglobulin (IVIG) therapy to a poor treatment regimen. This paper aims to increase physicians’ awareness of this condition, enhancing the likelihood of early diagnosis and treatment.…”
Get full text

Exploring dental students' knowledge on oral cancer prevention: a cross-sectional study in Moldova, Armenia, and Belarus by Olga Golburean, Diana Uncuta, Gayane Manrikyan, Natalia Shakavets, Izabella Vardanyan, Marina Markaryan, Ferda Özkaya, Daniela-Elena Costea, Tarig Al-Hadi Osman

“…Abstract Background Survival rate of patients with oral cancer (OC) remains to be very low despite advancements in therapy and surgical techniques. This is attributed to the fact that most OC cases are discovered at a late stage. …”
Get full text

Therapeutic effect of low-dose BMSCs-Loaded 3D microscaffold on early osteonecrosis of the femoral head by Minzheng Guo, Baochuang Qi, Zijie Pei, Haonan Ni, Junxiao Ren, Huan Luo, Hongxin Shi, Chen Meng, Yang Yu, Zhifang Tang, Yongqing Xu, Qingyun Xue, Chuan Li

“…In this study, we employed a novel cell carrier material termed ''3D Microscaffold'' to deliver BMSCs, addressing these issues and enhancing the therapeutic effects of cell therapy for ONFH. We injected 3D microscaffold loaded with low-dose BMSCs or free high-dose BMSCs into the femoral heads of ONFH rats and assessed therapeutic effects using imaging, serology, histology, and immunohistochemistry. …”
Get full text

Predictive Validity and Reliability of Frenchay Activities Index by Li TONG, Shanjia CHEN, Guanli XIE, Cai JIANG, Jing TAO, Lidian CHEN

“…Objective:To evaluate the reliability and validity of the Chinese version of the Frenchay activities index(FAI)in the recovery period of hospitalized stroke, and to provide evidence for the clinical use of the scale.Methods:The original English FAI was translated and revised according to the international standardized functional assessment of chronic illness therapy(FACIT)principle. An expert review group were formed with four rehabilitation professors, one professor of rehabilitation medicine and one professor of neurorehabilitation psychology, to conduct content validity review for Chinese FAI scale. …”
Get full text

Characteristics, clinical manifestations and management of leprosy in KwaZulu-Natal, South Africa: A 20-year retrospective study by J S Sons, Z N Mkhize, N C Dlova, C Aldous, P R Bhat, A V Chateau

“…Despite initiation of multidrug therapy in most patients, a significant proportion (27.3%) did not complete the full course of treatment, and treatment reactions were noted in 33.5% of patients. …”
Get full text

Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

Get full text

Comorbidities And Reducing InEquitieS (CARES): Feasibility of self-monitoring and community health worker support in management of comorbidities among Black breast and prostate can... by Laura C. Schubel, Ana Barac, Michelle Magee, Mihriye Mete, Malinda Peeples, Mansur Shomali, Kristen E. Miller, Lauren R. Bangerter, Allan Fong, Christopher Gallagher, Jeanne Mandelblatt, Hannah Arem

“…Methods: In a single arm, pre-post study, we enrolled patients with diabetes and/or hypertension who identified as Black and were diagnosed with 1) stage 0-IV breast cancer, or 2) prostate cancer and on long-term androgen-deprivation therapy. Participants received a home-monitoring device linked to a mobile app and worked with a CHW over six months to track their blood pressure (BP) and/or blood glucose (BG). …”
Get full text

FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Consequently, combining dietary serine restriction with targeted therapy against the ERK1/2-pELK1-FOXC1 axis could be a highly effective strategy for treating CRC, enhancing the efficacy of 5-FU.…”
Get full text

Effectiveness of Video Teletherapy in Treating Obsessive-Compulsive Disorder in Children and Adolescents With Exposure and Response Prevention: Retrospective Longitudinal Observati... by Jamie D Feusner, Nicholas R Farrell, Mia Nunez, Nicholas Lume, Catherine W MacDonald, Patrick B McGrath, Larry Trusky, Stephen Smith, Andreas Rhode

“… BackgroundAn effective primary treatment for obsessive-compulsive disorder (OCD) in children and adolescents as well as adults is exposure and response prevention (ERP), a form of intervention in the context of cognitive-behavioral therapy. Despite strong evidence supporting the efficacy and effectiveness of ERP from studies in research and real-world settings, its clinical use remains limited. …”
Get full text

Implementing a General Practice-Based Link Worker Intervention for People with Multimorbidity During the Covid-19 Pandemic- a Mixed Methods Process Evaluation of the LinkMM RCT by Bridget Kiely, Ivana Keenan, Sonali Loomba, Natalie Mack, Vivienne Byers, Emer Galvin, Muireann O’Shea, Patrick O’Donnell, Fiona Boland, Barbara Clyne, Eamon O’Shea, Susan M. Smith, Deirdre Connolly

Get full text

Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…Recently, oncolytic virus therapy has been recognized as a systemic immune stimulator. …”
Get full text

Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…Inhibiting the platelet receptors that modulate the PEVs’ cancer-promoting properties may open up new strategies for identifying promising treatment targets for cancer therapy.…”
Get full text

Retrospective Analysis of the Prevalence and Risk Factors of Retinopathy of Prematurity in a Single-Center Cohort in Romania and Comparison with National and European Data by Zsuzsánna Simon-Szabó, Sándor Pál, Aliz Pándi, Zsuzsanna Gáll, Hajnal Finta, Zsuzsánna Incze-Bartha, Cristina Maki, Manuela Cucerea

“…Identified risk factors in this cohort, such as respiratory distress syndrome, oxygen therapy, blood transfusion, and intraventricular hemorrhage, are consistent with the existing literature data. …”
Get full text

Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…Shiang-Yu Huang,1 Po-Chun Hsieh,2 Kuo-Liang Huang,3,4 Mei-Chen Yang,3,4 Lun-Yu Jao,3,4 I-Shiang Tzeng,5 Chou-Chin Lan,3,4,* Yao-Kuang Wu3,4,* 1Division of Respiratory Therapy, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China; 2Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China; 3Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China; 4School of Medicine, Tzu-Chi University, Hualien, Taiwan; 5Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, Republic of China*These authors contributed equally to this workCorrespondence: Yao-Kuang Wu, Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 289, Jianguo Road, Xindian City, New Taipei City, 23142, Taiwan, Republic of China, Tel +886-2-6628-9779 ext. 2259, Fax +886-2-6628-9009, Email drbfci@yahoo.com.twBackground: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, airflow limitation, reduced health-related quality of life (HRQL), and exercise intolerance. …”
Get full text

Implementasi Data Mining untuk Deteksi Penyakit Ginjal Kronis (PGK) menggunakan K-Nearest Neighbor (KNN) dengan Backward Elimination by Ikhsan Wisnuadji Gamadarenda, Indra Waspada

“…Allowing CKD to be prevented, addressed, and advised to get effective therapy is greater if acknowledged earlier. The process of this research uses work methods of Data Mining Knowledge Data Discovery (KDD). …”
Get full text

Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: seconda... by Helen Macpherson, Robin M Daly, Patricia M Livingston, Declan G Murphy, Patrick J Owen, Timo Rantalainen, Niamh L Mundell, Jeremy L Millar, Steve F Fraser, Jack Dalla Via, Stephen J Foulkes

“…Objectives The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT).Design 12-month, two-arm, randomised controlled trial.Setting University clinical exercise centre.Participants 70 ADT-treated men were randomised to exercise-training plus supplementation (Ex+ Suppl, n=34) or usual care (control, n=36).Intervention Men allocated to Ex + Suppl undertook thrice weekly resistance training with weight-bearing exercise training plus daily whey protein (25 g), calcium (1200 mg) and vitamin D (2000 IU) supplementation.Primary and secondary outcome measures Cognition was assessed at baseline, 6 and 12 months via a computerised battery (CogState), Trail-making test, Rey auditory-verbal learning test and Digit span. …”
Get full text

Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation by Yu Tang, Ruizhi Zhang, Gan Mao, Chong Li, Yisong Gao, Xuebing Zhou, Wenxiang Nie, Tianyu Song, Suao Liu, Kaixiong Tao, Peng Zhang, Wei Li

“…Deacetylase inhibitors have the potential to alter the secretion of chemokines for tumor immune cells, consequently enhancing the effectiveness of immune checkpoint inhibitor therapy in ARID1A-mutated gastric cancer.…”
Get full text

Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…EA potentially represents an effective adjunct method to increase the safety of thrombolytic therapy and extend the therapeutic time window of rtPA administration following ischemic stroke. …”
Get full text

A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria by Xiang Gao, Zixuan Wang, Xiang Li, Xiaoling Zhang, Shengqiang Du, Miaomiao Jia, Dailun Hu, Xianxian Jia, Bin Cong, Yan Zhang, Chunling Ma, Song Zhou, Jun Zhang

“…To search for a new eco-friendly therapy for infectious disease caused by Escherichia coli, Staphylococcus aureus or Klebsiella oxytoca, we collected the vaginal swabs from healthy women, screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria. …”
Get full text

A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…Multidisciplinary staff decided the initiation of antiretroviral therapy with tenofovir/emtricitabin/efavirenz and prophylaxis against opportunistic infections. …”
Get full text